US4970062A
Expired / Lapsed
US
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Colloid labelled with radionuclide and method
Assignee: United States Department of Energy
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Filing: 1989-05-30
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Granted: 1990-11-13
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Expires: 2009-05-30
Abstract
Abstract A ferric hydroxide colloid having an alpha-emitting radionuclide essentially on the outer surfaces and a method of forming same. The method includes oxidizing a ferrous hydroxide to ferric hydroxide in the presence of a preselected radionuclide to form a colloid having the radionuclide on the outer surface thereof, and thereafter washing the colloid, and suspending the washed colloid in a suitable solution. The labelled colloid is useful in cancer therapy and for the treatment of inflamed joints.
Inventors
- 👤 Robert W. Atcher
- 👤 John J. Hines
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 05:38
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1217; A61K9/00; A61K9/14; A61K9/16; A61K2121/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
16 words
A ferric hydroxide colloid having an alpha-emitting a radionuclide essentially only on the outer surfaces thereof.
Claim 2
Dependent Claim
16 words
A ferric hydroxide colloid having an alpha-emitting a radionuclide essentially only on the outer surfaces thereof.
Claim 3
Dependent Claim
31 words
The colloid of claim 1, wherein the radionuclide is selected from the group consisting of 211Bi, 212Bi, 213Bi, 214Bi, 212Pb, 228Th, 223Ra, 224Ra, 211At, 254Esm, 238Np, 234Np, 242Am and mixtures thereof.
Claim 4
Dependent Claim
10 words
The colloid of claim 1, wherein the radionuclide is 212Pb.
Claim 5
Dependent Claim
40 words
The method of claim 1, wherein the host has cancer cells and the colloid is administered by injection to the situs of the cancer cells in a therapeutically effective amount for a time sufficient to kill the cancer cells present.
Claim 6
Dependent Claim
13 words
The method of claim 4, wherein the colloid is administered in divided doses.
Claim 7
Dependent Claim
15 words
The method of claim 4, wherein the cancer cells are located in the peritoneal cavity.
Claim 8
Dependent Claim
15 words
The method of claim 4, wherein the cancer cells are located in the spinal column.
Claim 9
Dependent Claim
14 words
The method of claim 4, wherein the cancer cells are located in the liver.
Claim 10
Dependent Claim
14 words
The method of claim 4, wherein the cancer cells are located in pleural effusions.
Claim 11
Dependent Claim
22 words
The method of claim 4, wherein the colloid is injected into an artery in fluid communication with an organ infected with cancer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-11-12 | 1994-05-14 | 1994-11-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-11-12 | 1998-05-14 | 1998-11-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-11-12 | 2002-05-14 | 2002-11-13 | $7700.00 | Window Closed / Lapsed |