US4981950A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Vasoconstrictor peptide
Assignee: Agip SpA
•
Filing: 1988-09-26
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Granted: 1991-01-01
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Expires: 2008-09-26
Abstract
Abstract Disclosed is a vasoconstrictor peptide called Endothelin having a molecular weight of 2,500 +/- 300. Endothelin contains 21 amino acid residues, wherein four cysteines form two sets of S-S bond. In order to obtain the vasoconstrictor factors of the present invention, it is preferable to culture the endothelial cells collected from the vascular inner walls in a serum-free medium. The vasoconstrictor peptides of the present invention can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.
Inventors
- 👤 Tomoh Masaki
- 👤 Katsutoshi Goto
- 👤 Sadao Kimura
- 👤 Youji Mitsui
- 👤 Yoshio Yazaki
- 👤 Masashi Yanagisawa
- 👤 Hiroki Kurihara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 13:44
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/57536; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
12 words
A vasoconstrictor peptide consisting essentially of the following amino acid sequence: ##STR1##
Claim 2
Dependent Claim
12 words
A vasoconstrictor peptide consisting essentially of the following amino acid sequence: ##STR1##
Claim 3
Dependent Claim
14 words
Vasoconstrictor peptide as claimed in claim 1, which is of vascular endothelial cells origin.
Claim 4
Dependent Claim
16 words
Vasoconstrictor peptide as claimed in claim 1, wherein four cysteines form two sets of S--S bonds.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-12-31 | 1994-07-02 | 1995-01-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-12-31 | 1998-07-02 | 1999-01-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-12-31 | 2002-07-02 | 2003-01-01 | $7700.00 | Window Closed / Lapsed |