US4983376A
Expired / Lapsed
US
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Triazamacrocyclic NMR contrast agents and methods for their use
Assignee: The University of Texas System
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Filing: 1988-12-28
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Granted: 1991-01-08
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Expires: 2008-12-28
Abstract
Abstract Compositions for the enhancement of NMR contrast are disclosed which include a complex of a paramagnetic metal selected from the group consisting of gadolinium, manganese, iron, and chromium, with one of a group of triazamacrocyclic ligands. Methods for using such compositions are also disclosed.
Inventors
- 👤 A. Dean Sherry
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 08:10
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6524; A; A61; A61K; A61K49/00; A61K49/06; A61K51/00; A61K51/02; A61K51/04; C07D; C07D255/00; C07D255/02; C07D257/00; C07D257/02; C07F9/6515; A61K2123/00; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
84 words
An NMR contrast agent, comprising a complex of a paramagetic metal selected from the group consisting of gadolinium, manganese, iron, and chromium, with a ligand selected from the group consisting of compounds having the formula ##STR5## where R 1 is selected from the group consisting of: ##STR6## where R 2 is --C q H 2q+1 ; X is selected from the group consisting of --SO 3 H, --COOH, and salts thereof; n is 2-3; m is 2-3; p is 1-10; and q is 1-18.
Claim 2
Dependent Claim
84 words
An NMR contrast agent, comprising a complex of a paramagetic metal selected from the group consisting of gadolinium, manganese, iron, and chromium, with a ligand selected from the group consisting of compounds having the formula ##STR5## where R 1 is selected from the group consisting of: ##STR6## where R 2 is --C q H 2q+1 ; X is selected from the group consisting of --SO 3 H, --COOH, and salts thereof; n is 2-3; m is 2-3; p is 1-10; and q is 1-18.
Claim 3
Dependent Claim
9 words
The agent of claim 1, where p is 1-4.
Claim 4
Dependent Claim
9 words
The agent of claim 1, where q is 1-6.
Claim 5
Dependent Claim
11 words
The agent of claim 1, where the paramagnetic metal is gadolinium.
Claim 6
Dependent Claim
29 words
The agent of claim 1, where R 1 is selected from the group consisting of: ##STR7## where R 2 is --C q H 2q+1 , and q is 1--6.
Claim 7
Dependent Claim
56 words
An NMR contrast agent, comprising a complex of gadolinium with a ligand selected from the group consisting of compounds having the formula ##STR8## where R 1 is selected from the group consisting of: ##STR9## where R 2 is --C q H 2q+1 , n is 2--3, m is 2--3, p is 1--4, and q is 1-6.
Claim 8
Dependent Claim
56 words
An NMR contrast agent, comprising a complex of gadolinium with a ligand selected from the group consisting of compounds having the formula ##STR8## where R 1 is selected from the group consisting of: ##STR9## where R 2 is --C q H 2q+1 , n is 2--3, m is 2--3, p is 1--4, and q is 1-6.
Claim 9
Dependent Claim
88 words
An NMR contrast-enhancing composition, comprising: a complex of a paramagnetic metal selected from the group consisting of gadolinium, manganese, iron, and chromium, with a ligand selected from the group consisting of compounds having the formula ##STR10## where R 1 is selected from the group consisting of: ##STR11## where R 2 is --C q H 2q+1 ; X is selected from the group consisting of --SO 3 H, --COOH, and salts thereof; n is 2-3; m is 2-3; p is 1-10; and q is 1-18; and a sterile solvent.
Claim 10
Dependent Claim
88 words
An NMR contrast-enhancing composition, comprising: a complex of a paramagnetic metal selected from the group consisting of gadolinium, manganese, iron, and chromium, with a ligand selected from the group consisting of compounds having the formula ##STR10## where R 1 is selected from the group consisting of: ##STR11## where R 2 is --C q H 2q+1 ; X is selected from the group consisting of --SO 3 H, --COOH, and salts thereof; n is 2-3; m is 2-3; p is 1-10; and q is 1-18; and a sterile solvent.
Claim 11
Dependent Claim
9 words
The composition of claim 7, where p is 1-4.
Claim 12
Dependent Claim
9 words
The composition of claim 7, where q is 1-6.
Claim 13
Dependent Claim
11 words
The composition of claim 7, where the paramagnetic metal is gadolinium.
Claim 14
Dependent Claim
28 words
The composition of claim 7, where R' is selected from the group consisting of: ##STR12## where R 2 is --C q H 2q+1 , and q is 1-6.
Claim 15
Dependent Claim
61 words
An NMR contrast-enhancing composition, comprising: a complex of gadolinium with with a ligand selected from the group consisting of compounds having the formula ##STR13## where R 1 is selected from the group consisting of: ##STR14## where R 2 is --C q H 2q+1 , n is 2-3, m is 2-3, p is 1-4 and q is 1-6; and a sterile solvent.
Claim 16
Dependent Claim
61 words
An NMR contrast-enhancing composition, comprising: a complex of gadolinium with with a ligand selected from the group consisting of compounds having the formula ##STR13## where R 1 is selected from the group consisting of: ##STR14## where R 2 is --C q H 2q+1 , n is 2-3, m is 2-3, p is 1-4 and q is 1-6; and a sterile solvent.
Claim 17
Independent Claim
104 words
A method of enhancing NMR contrast in a living subject, including administering internally to the subject an effective amount of a contrast agent which comprises a complex of a paramagnetic metal selected from the group consisting of gadolinium, manganese, iron, and chromium, with a ligand selected from the group consisting of compounds having the formula ##STR15## where R 1 is selected from the group consisting of: ##STR16## where R 2 is --C q H 2q+1 ; X is selected from the group consisting of --SO 3 H, --COOH, and salts thereof; n is 2-3; m is 2-3; p is 1-10; and q is 1-18.
Claim 18
Independent Claim
104 words
A method of enhancing NMR contrast in a living subject, including administering internally to the subject an effective amount of a contrast agent which comprises a complex of a paramagnetic metal selected from the group consisting of gadolinium, manganese, iron, and chromium, with a ligand selected from the group consisting of compounds having the formula ##STR15## where R 1 is selected from the group consisting of: ##STR16## where R 2 is --C q H 2q+1 ; X is selected from the group consisting of --SO 3 H, --COOH, and salts thereof; n is 2-3; m is 2-3; p is 1-10; and q is 1-18.
Claim 19
Dependent Claim
9 words
The method of claim 13, where p is 1-4.
Claim 20
Dependent Claim
9 words
The method of claim 13, where q is 1-6.
Claim 21
Dependent Claim
11 words
The method of claim 13, where the paramagnetic metal is gadolinium.
Claim 22
Dependent Claim
30 words
The method of claim 13, where R 1 is selected from the group consisting of: ##STR17## where R 2 is --C q H 2q+1 , and where q is 1-6.
Claim 23
Independent Claim
76 words
A method of enhancing NMR contrast in a living subject, including administering internally to the subject an effective amount of a contrast agent which comprises a complex of gadolinium with a ligand selected from the group consisting of compounds having the formula ##STR18## where R 1 is selected from the group consisting of: ##STR19## where R 2 is --C q H 2q+1 , n is 2-3, m is 2-3, p is 1-4, and q is 1-6.
Claim 24
Independent Claim
76 words
A method of enhancing NMR contrast in a living subject, including administering internally to the subject an effective amount of a contrast agent which comprises a complex of gadolinium with a ligand selected from the group consisting of compounds having the formula ##STR18## where R 1 is selected from the group consisting of: ##STR19## where R 2 is --C q H 2q+1 , n is 2-3, m is 2-3, p is 1-4, and q is 1-6.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-01-07 | 1994-07-09 | 1995-01-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-01-07 | 1998-07-09 | 1999-01-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-01-07 | 2002-07-09 | 2003-01-08 | $7700.00 | Window Closed / Lapsed |