Patent US4985404A successfully refreshed from Google Patents.
US4985404A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Prolonged release of biologically active polypeptides
Assignee: Monsanto Technology LLC
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Filing: 1988-06-29
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Granted: 1991-01-15
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Expires: 2008-06-29
Abstract
Abstract Prolonged parenteral release of a bioactive polypeptide at desirably effective levels can be achieved using novel compositions in which the polypeptide is present in a biocompatible oil in an unusually high proportion such as at least about 10% by weight. Also disclosed are certain metal-associated somatotropins that are useful for prolonged parenteral release of such somatotropins.
Inventors
- 👤 James W. Mitchell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 16:59
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/08; A61K47/12; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/27; A61K47/44; A61K9/00; A61K9/0012; A61K9/0019
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
76 words
A somatotropin-containing particulate for use in a parenteral release formulation having biological compatibility with a porcine animal comprising the reaction product of a porcine somatotropin and ions of a metal selected from the group consisting of zinc, iron, calcium, bismuth, barium, magnesium, manganese, aluminum, copper, cobalt, nickel and cadmium which are present in the reaction product in an amount up to about 2% by weight sufficient to prolong the release of the somatotropin from the formulation.
Claim 2
Dependent Claim
76 words
A somatotropin-containing particulate for use in a parenteral release formulation having biological compatibility with a porcine animal comprising the reaction product of a porcine somatotropin and ions of a metal selected from the group consisting of zinc, iron, calcium, bismuth, barium, magnesium, manganese, aluminum, copper, cobalt, nickel and cadmium which are present in the reaction product in an amount up to about 2% by weight sufficient to prolong the release of the somatotropin from the formulation.
Claim 3
Dependent Claim
68 words
A somatotropin-containing composition for use in a parenteral release formulation having biological compatibility with a porcine animal comprising a porcine somatotropin and a water soluble compound of a metal selected from the group consisting of zinc, iron, calcium, bismuth, barium, magnesium, manganese, aluminum, copper, cobalt, nickel and cadmium in an amount up to about 2% by weight sufficient to prolong the release of the somatotropin from the formulation.
Claim 4
Dependent Claim
68 words
A somatotropin-containing composition for use in a parenteral release formulation having biological compatibility with a porcine animal comprising a porcine somatotropin and a water soluble compound of a metal selected from the group consisting of zinc, iron, calcium, bismuth, barium, magnesium, manganese, aluminum, copper, cobalt, nickel and cadmium in an amount up to about 2% by weight sufficient to prolong the release of the somatotropin from the formulation.
Claim 5
Dependent Claim
83 words
A metal associated somatotropin complex suitable for use in a prolonged release formulation intended parenteral administration to an animal by injection or implantation comprising the reaction product of somatotropin ions of a metal selected from the group consisting of zinc, iron, calcium, bismuth, barium, magnesium, manganese, aluminum, copper, cobalt, nickel and cadmium, said metal ions comprising up to about 2% by weight of said reaction product and being present in an amount sufficient to prolong the release of said somatotropin from said formulation.
Claim 6
Dependent Claim
83 words
A metal associated somatotropin complex suitable for use in a prolonged release formulation intended parenteral administration to an animal by injection or implantation comprising the reaction product of somatotropin ions of a metal selected from the group consisting of zinc, iron, calcium, bismuth, barium, magnesium, manganese, aluminum, copper, cobalt, nickel and cadmium, said metal ions comprising up to about 2% by weight of said reaction product and being present in an amount sufficient to prolong the release of said somatotropin from said formulation.
Claim 7
Dependent Claim
25 words
The somatotropin complex of claim 3 wherein the mole ratio of metal ions to somatotropin in said reaction product is from about 1:1 to 4:1.
Claim 8
Dependent Claim
13 words
The somatotropin complex of claim 3 wherein said somatotropin is bovine or porcine.
Claim 9
Dependent Claim
17 words
The somatotropin complex of claim 3 wherein said somatotropin is bovine and said metal ion is zinc.
Claim 10
Dependent Claim
17 words
The somatotropin complex of claim 3 wherein said somatotropin is porcine and said metal ion is copper.
Claim 11
Dependent Claim
19 words
The somatotropin complex of claim 3 wherein said metal associated somatotropin complex is substantially free of unreacted metal ions.
Claim 12
Dependent Claim
71 words
A somatotropin composition having prolonged release characteristics upon parenteral administration to an animal comprising somatotropin and a water-soluble compound of a metal ion selected from the group consisting of zinc, iron, calcium, bismuth, barium, magnesium, manganese, aluminum, copper, cobalt, nickel and cadmium, said metal ions comprising up to about 2% by weight of said composition and being present in an amount sufficient to prolong the release of somatotropin from said composition.
Claim 13
Dependent Claim
71 words
A somatotropin composition having prolonged release characteristics upon parenteral administration to an animal comprising somatotropin and a water-soluble compound of a metal ion selected from the group consisting of zinc, iron, calcium, bismuth, barium, magnesium, manganese, aluminum, copper, cobalt, nickel and cadmium, said metal ions comprising up to about 2% by weight of said composition and being present in an amount sufficient to prolong the release of somatotropin from said composition.
Claim 14
Dependent Claim
22 words
The composition of claim 9 wherein the mole ratio of said metal ions to said somatotropin is from about 1:1 to 4:1.
Claim 15
Dependent Claim
12 words
The composition of claim 9 wherein said somatotropin is bovine or porcine.
Claim 16
Dependent Claim
16 words
The composition of claim 9 wherein said somatotropin is bovine and said metal ion is zinc.
Claim 17
Dependent Claim
16 words
The composition of claim 9 wherein said somatotropin is porcine and said metal ion is copper.
Claim 18
Dependent Claim
15 words
The composition of claim 9 wherein said metal ions are provided by a water-soluble compound.
References Cited (Backward Citations)
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| 7.5 Years (Year 8) | 1998-01-14 | 1998-07-16 | 1999-01-15 | $3760.00 | Window Closed / Lapsed |
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