1,3-dideoxy-3-fluoronojirimycin which inhibits glycosidase activity

Claim 2

Compound represented by the formula: ##STR24## wherein R represents hydrogen, alkyl radicals having from 1 to about 10 carbon atoms, alkenyl radicals having from 2 to about 10 carbon atoms, aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and radicals represented by the formula: ##STR25## wherein R' represents alkyl radicals, having from about 1 to about 10 carbon atoms, and aryl, aralkyl and alkaryl radicals having from about 6 to about 26 carbon atoms, A represents oxygen, and n is 0 or 1.

Claim 3

Compound of claim 1 wherein R represents hydrogen.

Claim 4

Compound of claim 1 wherein R represents an alkyl radical having from 1 to about 10 carbon atoms.

Claim 5

Compound of claim 1 wherein R represents an alkyl radical having from 1 to about 6 carbon atoms.

Claim 6

Compound of claim 1 wherein R represents an alkyl radical having 4 carbon atoms.

Claim 7

Compound of claim 1 wherein R is n-butyl.

Claim 8

N-butyl-1,3-dideoxy-3-fluoronojirimycin.

Claim 9

N-butyl-1,3-dideoxy-3-fluoronojirimycin.

Claim 10

1,3-dideoxy-3-fluoronojirimycin.

Claim 11

1,3-dideoxy-3-fluoronojirimycin.

Claim 12

Composition for inhibiting glycosidase activity comprising a compound of claim 1 and a pharmaceutically acceptable diluent and/or carrier.

Claim 13

Compound represented by the formula: ##STR26## wherein R represents hydrogen, alkyl radicals having from 1 to about 10 carbon atoms, alkenyl radicals having from 2 to about 10 carbon atoms, aryl, aralkyl and alkaryl radials having from about 6 to about 16 carbon atoms and radicals represented by the formula: ##STR27## wherein R' represents alkyl radicals, having from 1 to about 10 carbon atoms, and aryl, aralkyl and alkaryl radicals having from about 6 to about 26 carbon atoms, A represents oxygen, and n is 0 or 1; and R 8 and R 9 independently represent hydrogen, alkyl radicals having from 1 to about 10 carbon atoms and aryl radicals.

Claim 14

Compound represented by the formula: ##STR26## wherein R represents hydrogen, alkyl radicals having from 1 to about 10 carbon atoms, alkenyl radicals having from 2 to about 10 carbon atoms, aryl, aralkyl and alkaryl radials having from about 6 to about 16 carbon atoms and radicals represented by the formula: ##STR27## wherein R' represents alkyl radicals, having from 1 to about 10 carbon atoms, and aryl, aralkyl and alkaryl radicals having from about 6 to about 26 carbon atoms, A represents oxygen, and n is 0 or 1; and R 8 and R 9 independently represent hydrogen, alkyl radicals having from 1 to about 10 carbon atoms and aryl radicals.

Claim 15

Compound of claim 10 wherein R represents hydrogen.

Claim 16

Compound of claim 10 wherein R represents an alkyl radical having from 1 to about 10 carbon atoms.

Claim 17

Compound of claim 10 wherein R represents an alkyl radical having from 1 to about 6 carbon atoms.

Claim 18

Compound of claim 10 wherein R represents an alkyl radical having 4 carbon atoms.

Claim 19

Compound of claim 10 wherein R is n-butyl.

Claim 20

Compound of claim 10 wherein R represents a carbobenzoxy radical.

Claim 21

Compound of claim 10 wherein R represents a butyryl radical.

Claim 22

Composition for inhibiting glycosidase activity comprising a compound of claim 10 and a pharmaceutically acceptable diluent and/or carrier.

Claim 23

Compound represented by the formula: ##STR28## wherein R represents hydrogen, alkyl radicals having from 1 to about 10 carbon atoms, alkenyl radicals having from 2 to about 10 carbon atoms, aryl, aralkyl and alkaryl radials having from about 6 to about 16 carbon atoms and radicals represented by the formula: ##STR29## wherein R' represents alkyl radicals, having from 1 to about 10 carbon atoms, and aryl, aralkyl and alkaryl radicals having from about 6 to about 26 carbon atoms, A represents oxygen, and n is 0 or 1; R 3 represents benzyl and allyl ethers, and acyl esters represented by the formula ##STR30## wherein R 10 represents alkyl radicals having from 1 to about 10 carbon atoms and aryl, aralkyl and alkaryl radicals; and R 8 and R 9 independently represent hydrogen, alkyl radicals having from 1 to about 10 carbon atoms and aryl radicals.

Claim 24

Compound represented by the formula: ##STR28## wherein R represents hydrogen, alkyl radicals having from 1 to about 10 carbon atoms, alkenyl radicals having from 2 to about 10 carbon atoms, aryl, aralkyl and alkaryl radials having from about 6 to about 16 carbon atoms and radicals represented by the formula: ##STR29## wherein R' represents alkyl radicals, having from 1 to about 10 carbon atoms, and aryl, aralkyl and alkaryl radicals having from about 6 to about 26 carbon atoms, A represents oxygen, and n is 0 or 1; R 3 represents benzyl and allyl ethers, and acyl esters represented by the formula ##STR30## wherein R 10 represents alkyl radicals having from 1 to about 10 carbon atoms and aryl, aralkyl and alkaryl radicals; and R 8 and R 9 independently represent hydrogen, alkyl radicals having from 1 to about 10 carbon atoms and aryl radicals.

Claim 25

Compound of claim 19 wherein R represents hydrogen.

Claim 26

Compound of claim 19 wherein R represents an alkyl radical having from 1 to about 10 carbon atoms.

Claim 27

Compound of claim 19 wherein R represents an alkyl radical having from 1 to about 6 carbon atoms.

Claim 28

Compound of claim 19 wherein R represents an alkyl radical having 4 carbon atoms.

Claim 29

Compound of claim 19 wherein R is n-butyl.

Claim 30

Compound of claim 19 wherein R represents a carbobenzoxy radical.

Claim 31

Compound of claim 19 wherein R represents a butyryl radical.

Claim 32

Composition for inhibiting glycosidase activity comprising a compound of claim 19 and a pharmaceutically acceptable diluent and/or carrier.