US5036057A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of treating gastroesophageal reflux
Assignee: University of Melbourne
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Filing: 1989-06-21
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Granted: 1991-07-30
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Expires: 2009-06-21
Abstract
Abstract A pharmaceutical composition comprising a local anaesthetic adapted to inhibit relaxation of the lower oesophageal sphincter and a carrier therefor comprising a material adapted to float on gastrointestinal fluids contained in the stomach whereby to be more proximate to the gastric mucosa below said sphincter, than said fluids.
Inventors
- 👤 Christopher J. Martin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 18:57
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0065; A61K9/0002; A61K9/0007; A61K9/0056
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
131 words
A method of delivering a local anaesthetic proximate to the fundic mucosa in the fundus of the stomach for the treatment of gastroesophageal reflux, said method comprising administering to a host in need thereof a pharmaceutical composition comprising: (i) a local anaesthetic in an amount sufficient to indirectly inhibit relaxation of the local oesophageal sphincter by acting on mechanoreceptors located in the fundus of the stomach, and (ii) a carrier for said local anaesthetic, said carrier comprising a material adapted to float on gastrointestinal fluids contained in the stomach such that said carrier is more proximate to the gastric mucosa below said sphincter than said gastrointestinal fluids, said carrier being accordingly adapted to deliver said local anaesthetic to the fundic mucosa such that it is able to act on said mechanoreceptors.
Claim 2
Independent Claim
131 words
A method of delivering a local anaesthetic proximate to the fundic mucosa in the fundus of the stomach for the treatment of gastroesophageal reflux, said method comprising administering to a host in need thereof a pharmaceutical composition comprising: (i) a local anaesthetic in an amount sufficient to indirectly inhibit relaxation of the local oesophageal sphincter by acting on mechanoreceptors located in the fundus of the stomach, and (ii) a carrier for said local anaesthetic, said carrier comprising a material adapted to float on gastrointestinal fluids contained in the stomach such that said carrier is more proximate to the gastric mucosa below said sphincter than said gastrointestinal fluids, said carrier being accordingly adapted to deliver said local anaesthetic to the fundic mucosa such that it is able to act on said mechanoreceptors.
Claim 3
Dependent Claim
25 words
The method of claim 1 wherein said carrier includes a foam, or a material adapted to form a foam in the presence of gastrointestinal fluids.
Claim 4
Dependent Claim
22 words
The method of claim 2 wherein said carrier includes a material adapted to form a foam cell wall and a blowing agent.
Claim 5
Dependent Claim
19 words
The method of claim 1 wherein the local anaesthetic is selected from cocaine, oxethazine, benzocaine, amethocaine, cinchocaine, and lignocaine.
Claim 6
Dependent Claim
22 words
The method of claim 3 wherein said material adapted to form a foam cell wall is selected for alginic acid and alginates.
Claim 7
Independent Claim
161 words
A method of delivering a local anaesthetic proximate to the fundic mucosa in the fundus of the stomach for the treatment of gastroesophageal reflux, said method comprising administering to a host in need thereof a pharmaceutical composition comprising: (i) a local anaesthetic in an amount sufficient to indirectly inhibit relaxation of the local oesophageal sphincter by acting on mechanoreceptors located in the fundus of the stomach, and (ii) a carrier for said local anaesthetic, said carrier comprising a material adapted to float on gastrointestinal fluids contained in the stomach such that said carrier is more proximate to the gastric mucosa below said sphincter than said gastrointestinal fluids, said carrier including a material adapted to form a foam in the presence of gastrointestinal fluids and a material adapted to form a foam cell wall and a blowing agent, said carrier being accordingly adapted to deliver said local anaesthetic to the fundic mucosa such that it is able to act on said mechanoreceptors.
Claim 8
Independent Claim
161 words
A method of delivering a local anaesthetic proximate to the fundic mucosa in the fundus of the stomach for the treatment of gastroesophageal reflux, said method comprising administering to a host in need thereof a pharmaceutical composition comprising: (i) a local anaesthetic in an amount sufficient to indirectly inhibit relaxation of the local oesophageal sphincter by acting on mechanoreceptors located in the fundus of the stomach, and (ii) a carrier for said local anaesthetic, said carrier comprising a material adapted to float on gastrointestinal fluids contained in the stomach such that said carrier is more proximate to the gastric mucosa below said sphincter than said gastrointestinal fluids, said carrier including a material adapted to form a foam in the presence of gastrointestinal fluids and a material adapted to form a foam cell wall and a blowing agent, said carrier being accordingly adapted to deliver said local anaesthetic to the fundic mucosa such that it is able to act on said mechanoreceptors.
Claim 9
Dependent Claim
22 words
The method of claim 6 wherein said blowing agent is one capable of being decomposed by gastrointestinal fluids to produce carbon dioxide.
Claim 10
Dependent Claim
19 words
The method of claim 6 wherein the local anaesthetic is selected from cocaine, oxethazine, benzocaine, amethocaine, cinchocaine and lignocaine.
Claim 11
Dependent Claim
23 words
The method of claim 1 wherein the local anaesthetic is present in said composition in an amount of 1% to 10% by weight.
Claim 12
Dependent Claim
23 words
The method of claim 6 wherein the local anaesthetic is present in said composition in an amount of 1% to 10% by weight.
References Cited (Backward Citations)
US4140760A
Cited
GB2074026A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-29 | 1995-01-28 | 1995-07-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-29 | 1999-01-28 | 1999-07-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-29 | 2003-01-28 | 2003-07-30 | $7700.00 | Window Closed / Lapsed |