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US5082831A
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Total body washout solution and method of use
Assignee: Cryovita Laboratories Inc
•
Filing: 1989-12-05
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Granted: 1992-01-21
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Expires: 2009-12-05
Abstract
Abstract The present invention is concerned with improved aqueous asanguineous perfusates, blood substitutes for profound hypothermia, and method of using the same. The perfusates comprise: -Component Molar Conc., mM Grams/liter -Hydroxyethyl starch, 40 to 60 gms -MW = 500,000 -Glucose 5-15 0.9-2.7 -Sodium bicarbonate 5-20 0.42-1.68 -Potassium chloride 15-40 1.15-3.33 -Calcium chloride 0.5-2.04 0.074-0.294 -Magnesium chloride 0.25-2.5 0.051-0.510 -HEPES or THAM 7.2-15 1.72-3.90 -Sodium phosphate, 7.2-15 -monobasic, MW = 120.0 -Mannitol or sucrose 0-170 0-30.97. -
Inventors
- 👤 Jerry D. Leaf
- 👤 Michael G. Federowicz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 15:37
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
67 words
An aqueous perfusate composition comprising: ______________________________________
Component Molar Conc., mM
Grams/Liter
______________________________________
Hydroxyethyl starch,
40 to 60 gms
MW = 500,000
Glucose 5-15 0.9-2.7
Sodium bicarbonate
5-20 0.42-1.68
Potassium chloride
15-40 1.15-3.33
Calcium chloride
0.5-2.04 0.074-0.294
Magnesium chloride
0.25-2.5 0.051-0.51
HEPES or THAM 7.2-15 1.72-3.90
Sodium phosphate,
7.2-15
monobasic, MW = 120.0
Mannitol or sucrose
0-170 0-30.97
______________________________________ and an effective amount of heparin to prevent coagulation.
Claim 2
Dependent Claim
67 words
An aqueous perfusate composition comprising: ______________________________________
Component Molar Conc., mM
Grams/Liter
______________________________________
Hydroxyethyl starch,
40 to 60 gms
MW = 500,000
Glucose 5-15 0.9-2.7
Sodium bicarbonate
5-20 0.42-1.68
Potassium chloride
15-40 1.15-3.33
Calcium chloride
0.5-2.04 0.074-0.294
Magnesium chloride
0.25-2.5 0.051-0.51
HEPES or THAM 7.2-15 1.72-3.90
Sodium phosphate,
7.2-15
monobasic, MW = 120.0
Mannitol or sucrose
0-170 0-30.97
______________________________________ and an effective amount of heparin to prevent coagulation.
Claim 3
Dependent Claim
13 words
A perfusate composition of claim 1 containing about 1,000 IU heparin per liter.
Claim 4
Dependent Claim
19 words
A perfusate composition of claim 1, the pH of which has been adjusted to about 8.0 to about 8.2.
Claim 5
Dependent Claim
13 words
A perfusate composition of claim 1 which contains 3 to 5 mM glutathione.
Claim 6
Dependent Claim
48 words
A perfusate composition consisting essentially of the following: ______________________________________
Component mMols Gms/liter
______________________________________
Hydroxyethyl starch,
55 gms
MW = 500,000
Glucose 10.0 1.8
Sodium bicarbonate
10.0 0.84
Potassium chloride
28.34 2.11
Calcium chloride 1.0 0.11
Magnesium chloride
1.0 0.095
HEPES or THAM 7.2 1.72
Mannitol 170 30.97
______________________________________
Claim 7
Dependent Claim
48 words
A perfusate composition consisting essentially of the following: ______________________________________
Component mMols Gms/liter
______________________________________
Hydroxyethyl starch,
55 gms
MW = 500,000
Glucose 10.0 1.8
Sodium bicarbonate
10.0 0.84
Potassium chloride
28.34 2.11
Calcium chloride 1.0 0.11
Magnesium chloride
1.0 0.095
HEPES or THAM 7.2 1.72
Mannitol 170 30.97
______________________________________
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-01-20 | 1995-07-22 | 1996-01-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-01-20 | 1999-07-22 | 2000-01-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-01-20 | 2003-07-22 | 2004-01-21 | $7700.00 | Window Closed / Lapsed |