US5091185A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Coated veterinary implants
Assignee: Monsanto Technology LLC
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Filing: 1990-06-20
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Granted: 1992-02-25
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Expires: 2010-06-20
Abstract
Abstract Solid dosage forms of bioactive materials for parenteral administration such as porcine or bovine somatotropin pellets intended for subcutaneous implantation to improve food production of farm animals are coated with polyvinyl alcohol to extend the release characteristics of the material. The polyvinyl alcohol preferably has a molecular weight of from about 20,000 to 100,000, a degree of hydrolysis of at least about 98%, and is applied from an aqueous solution by spray coating to form a continuous uniform covering of from about 3 to 25 ug/mm<2> PVA/surface area of pellet.
Inventors
- 👤 Ernesto J. Castillo
- 👤 Kenneth E. Eigenberg
- 👤 Kanaiyalal R. Patel
- 👤 Milton J. Sabacky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 15:47
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/28; A61K9/0012; A61K9/0019; A61K9/0024; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/27; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5026; A61P; A61P15/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
99 words
A coated veterinary implant of a growth hormone having extended release delivery characteristics upon parenteral administration to an animal, said implant comprising a solid core of said growth hormone in an amount sufficient to provide an effective dose for the desired biological response over an extended period of delivery, and a release inhibiting coating of polyvinyl alcohol continuously enveloping said core, said polyvinyl alcohol having a molecular weight of at least about 10,000a degree of hydrolysis of at least about 95%, and being present in an amount of from about 0.5 to 5 percent by weight of said implant.
Claim 2
Dependent Claim
99 words
A coated veterinary implant of a growth hormone having extended release delivery characteristics upon parenteral administration to an animal, said implant comprising a solid core of said growth hormone in an amount sufficient to provide an effective dose for the desired biological response over an extended period of delivery, and a release inhibiting coating of polyvinyl alcohol continuously enveloping said core, said polyvinyl alcohol having a molecular weight of at least about 10,000a degree of hydrolysis of at least about 95%, and being present in an amount of from about 0.5 to 5 percent by weight of said implant.
Claim 3
Dependent Claim
25 words
The implant of claim 1 wherein said coating of polyvinyl alcohol is present in an amount of from about 3 to 25 ug/mm 2 .
Claim 4
Dependent Claim
23 words
The implant of claim 1 wherein said coating of polyvinyl alcohol is substantially uniform over the surface of said core of growth hormone.
Claim 5
Dependent Claim
14 words
The implant of claim 1 wherein said growth hormone is bovine or porcine somatotropin.
Claim 6
Dependent Claim
14 words
The implant of claim 4 wherein said somatotropin is associated with a metal ion.
Claim 7
Dependent Claim
16 words
The implant of claim 5 wherein said somatotropin is porcine and said metal ion is copper.
Claim 8
Dependent Claim
16 words
The implant of claim 5 wherein said somatotropin is bovine and said metal ion is zinc.
Claim 9
Dependent Claim
18 words
The implant of claim 1 in the form of a pellet having a cylindrical, oval or spherical shape.
Claim 10
Dependent Claim
19 words
The implant of claim 1 wherein said polyvinyl alcohol has a molecular weight of from about 20,000 to 100,000.
Claim 11
Dependent Claim
19 words
The implant of claim 9 wherein said polyvinyl alcohol has a degree of hydrolysis of at least about 98%.
References Cited (Backward Citations)
US4173626A
Cited
US4526938A
Cited
US4808353A
Cited
US4882167A
Cited
US4738679A
Cited
US4793997A
Cited
US4786501A
Cited
US4765980A
Cited
US4882137A
Cited
US4761289A
Cited
US4863736A
Cited
US4891223A
Cited
US4837033A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-02-24 | 1995-08-26 | 1996-02-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-02-24 | 1999-08-26 | 2000-02-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-02-24 | 2003-08-26 | 2004-02-25 | $7700.00 | Window Closed / Lapsed |