Patent US5136033A successfully refreshed from Google Patents.
US5136033A
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Ion selective fluorogenic reagents
Assignee: Honeywell International Inc
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Filing: 1987-08-24
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Granted: 1992-08-04
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Expires: 2007-08-24
Abstract
Abstract Novel fluorogenic ionophores have been synthesized which selectively bind ions such as potassium and sodium, even in neutral aqueous and alcoholic media and respond to such binding by fluorescence quenching or enhancement. These ionophores are ideal for the selective and direct determination of ions in biological or environmental samples and the like. The ionophores are also suitable for incorporation into fiber optic-based sensors for the continuous in vivo or in vitro monitoring of metal ions in blood or other biological fluids.
Inventors
- 👤 Divakaran Masilamani
- 👤 Mariann E. Lucas
- 👤 George S. Hammond
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 12:29
CPC Classifications
C; C07; C07D; C07D273/00; C07D493/00; C07D493/02; C07D493/04; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/84
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
111 words
An ionophore compound of an ion-recognizing system fused to a signal moiety through two heteroatoms having a non-bonded electron pair, having the formula: ##STR15## wherein said signal moiety is selected from the group consisting of unsubstituted and substituted coumarins, and wherein said ion-recognizing system is a crown ether wherein X 1 , and X 2 of said crown ether are the same or different and are selected from the group consisting of S, P, N, O, and Se, Y 1 and Y 2 are the same or different and are selected from the group consisting of O, N, S, and C; and wherein the repeating unit m is 0 to 12.
Claim 2
Dependent Claim
111 words
An ionophore compound of an ion-recognizing system fused to a signal moiety through two heteroatoms having a non-bonded electron pair, having the formula: ##STR15## wherein said signal moiety is selected from the group consisting of unsubstituted and substituted coumarins, and wherein said ion-recognizing system is a crown ether wherein X 1 , and X 2 of said crown ether are the same or different and are selected from the group consisting of S, P, N, O, and Se, Y 1 and Y 2 are the same or different and are selected from the group consisting of O, N, S, and C; and wherein the repeating unit m is 0 to 12.
Claim 3
Dependent Claim
28 words
The ionophore of claim 1 wherein X 1 and X 2 are the same or different and are selected from the group consisting of S, O and N.
Claim 4
Dependent Claim
20 words
The ionophore compound of claim 1 wherein X 1 and X 2 are the same and are O or N.
Claim 5
Dependent Claim
12 words
The ionophore compound of claim 3 wherein m is 0 to 3.
Claim 6
Dependent Claim
12 words
The ionophore compound of claim 4 wherein m is 0 or 1.
Claim 7
Dependent Claim
59 words
The ionophore compound of claim 1 wherein the ionophore compound corresponds to a formula selected from the group consisting of: ##STR16## wherein R 1 , R 2 , R 3 and R 4 are the same or different and are H, hydroxyl, amino, alkyl, aromatic hydrocarbyl, fluoroalkyl, alkylcarbonyloxyl, carboxyl, alkoxyl, mercapto or alkylthio and CE represents a crown ether.
Claim 8
Dependent Claim
13 words
A compound having the following formula: ##STR17## wherein CE is a crown ether.
Claim 9
Dependent Claim
13 words
A compound having the following formula: ##STR17## wherein CE is a crown ether.
Claim 10
Dependent Claim
34 words
The compound of claim 6 wherein R 1 , R 2 , R 3 and R 4 are the same or different and are selected from H and alkyl having 1 to 4 carbons.
Claim 11
Dependent Claim
31 words
The compound of claim 6 wherein R 1 , R 2 , R 3 and R 4 are the same or different and are selected from H or methyl or ethyl.
Claim 12
Dependent Claim
24 words
A compound according to claim 7 having the formula: ##STR18## wherein said compound is a fluorogenic reagent selective for the detection of potassium ion.
Claim 13
Dependent Claim
24 words
A compound according to claim 7 having the formula: ##STR19## wherein said compound is a fluorogenic reagent selective for the detection of potassium ion.
Claim 14
Dependent Claim
23 words
A compound according to claim 7 having the formula: ##STR20## wherein said compound is a fluorogenic reagent for the detection of sodium ion.
Claim 15
Dependent Claim
135 words
An ionophore compound comprising an ion-recognizing system fused to a signal moiety through two heteroatoms having a non-bonded electron pair, having the formula: ##STR21## wherein said signal moiety is selected from the group consisting of unsubstituted and substituted coumarins, and wherein said ion-recognizing system is a crown ether, wherein X 1 , and X 2 of said crown ether are the same or different and are selected from the group consisting of S, P, N, O, and Se, Y 1 and Y 2 are the same or different and are selected from the group consisting of O, N, S, and C; and wherein the repeating unit m is 0 to 12; and wherein r ranges from 0-15 and Q is a quenching group selected from aceto, propionyl, bromoaceto, chloroaceto, benzoyl, dinitrobenzoyl, methylcarbonyl, phenylcarbonyl and cyclohexylcarbonyl.
Claim 16
Dependent Claim
135 words
An ionophore compound comprising an ion-recognizing system fused to a signal moiety through two heteroatoms having a non-bonded electron pair, having the formula: ##STR21## wherein said signal moiety is selected from the group consisting of unsubstituted and substituted coumarins, and wherein said ion-recognizing system is a crown ether, wherein X 1 , and X 2 of said crown ether are the same or different and are selected from the group consisting of S, P, N, O, and Se, Y 1 and Y 2 are the same or different and are selected from the group consisting of O, N, S, and C; and wherein the repeating unit m is 0 to 12; and wherein r ranges from 0-15 and Q is a quenching group selected from aceto, propionyl, bromoaceto, chloroaceto, benzoyl, dinitrobenzoyl, methylcarbonyl, phenylcarbonyl and cyclohexylcarbonyl.
Claim 17
Dependent Claim
19 words
The ionophore of claim 1 wherein said ionophore is capable of selectively recognizing a Na, K or Li ion.
References Cited (Backward Citations)
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