Patent US5149540A successfully refreshed from Google Patents.
US5149540A
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Thrombin composition for oral administration
Assignee: Mochida Pharmaceutical Co Ltd
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Filing: 1991-02-27
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Granted: 1992-09-22
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Expires: 2011-02-27
Abstract
Abstract A stable thrombin composition for oral administration having an excellent solubility is prepared with thrombin as a hemostatic ingredient, gelatin, albumin and glycine as a stabilizer and sucrose and/or sugar alcohol as a carrier. The thrombin composition is effective for the treatment of hemorrhage in the upper alimentary canal, is stable even at room temperature conditions for long periods of time, has excellent solubility and can be orally administered in a simple manner.
Inventors
- 👤 Yasuyuki Kunihiro
- 👤 Ryo Tanaka
- 👤 Seishichi Hata
- 👤 Koji Yamada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 09:43
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61K38/482; A61K38/4833; A61K47/00; A61K47/06; A61K47/16; A61K47/18; A61K47/183; A61K47/26; A61K47/30; A61K47/42; A61P; A61P1/00; A61P1/04; A61P7/00; A61P7/04
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
57 words
A hemostatically solid composition comprising: a hemostatically effective amount of thrombin as an active ingredient; 0.9 to 9.0 wt % of at least one stabilizer selected from the group consisting of gelatin, albumin and glycine; and more than 89.0 to 99.0 wt % of at least one carrier selected from the group consisting of sucrose and mannitol.
Claim 2
Dependent Claim
57 words
A hemostatically solid composition comprising: a hemostatically effective amount of thrombin as an active ingredient; 0.9 to 9.0 wt % of at least one stabilizer selected from the group consisting of gelatin, albumin and glycine; and more than 89.0 to 99.0 wt % of at least one carrier selected from the group consisting of sucrose and mannitol.
Claim 3
Dependent Claim
10 words
The composition of claim 1, wherein said stabilizer is gelatin.
Claim 4
Dependent Claim
18 words
The composition of claim 1, wherein said composition is in the form of granules, fine granules or powders.
Claim 5
Dependent Claim
16 words
The composition of claim 1, wherein the composition is in a form suitable for oral administration.
Claim 6
Dependent Claim
9 words
The composition of claim 1, further comprising a solvent.
Claim 7
Dependent Claim
25 words
The composition of claim 5, wherein said solvent is selected from the group consisting of buffer solution, milk, isotonic sodium chloride solution, and distilled water.
Claim 8
Dependent Claim
18 words
The composition of claim 5, containing 50 to 1000 units of said thrombin per milliliter of said solvent.
Claim 9
Dependent Claim
19 words
The composition of claim 6, containing 200 to 400 units of said thrombin per milliliter of said buffer solution.
Claim 10
Dependent Claim
25 words
The composition of claim 1, said composition being stable for from 1 month to 6 months at room temperature and relative humidity of from 70-80%.
Claim 11
Independent Claim
63 words
A method of treating hemorrhage by administration of a hemostatically solid composition comprising: a hemostatically effective amount of thrombin as an active ingredient; 0.1 to 9.0 wt % of at least one stabilizer selected from the group consisting of gelatin, albumin and glycine; and more than 90.0 wt % of at least one carrier selected from the group consisting of sucrose and mannitol.
Claim 12
Independent Claim
63 words
A method of treating hemorrhage by administration of a hemostatically solid composition comprising: a hemostatically effective amount of thrombin as an active ingredient; 0.1 to 9.0 wt % of at least one stabilizer selected from the group consisting of gelatin, albumin and glycine; and more than 90.0 wt % of at least one carrier selected from the group consisting of sucrose and mannitol.
Claim 13
Dependent Claim
14 words
The method of claim 10, wherein said hemorrhage is in the upper alimentary canal.
Claim 14
Dependent Claim
10 words
The method of claim 10, wherein said stabilizer is gelatin.
Claim 15
Dependent Claim
18 words
The method of claim 10, wherein said composition is in the form of granules, fine granules or powders.
Claim 16
Dependent Claim
11 words
The method of claim 10, wherein the composition is administered orally.
Claim 17
Dependent Claim
10 words
The composition of claim 1, wherein said carrier is sucrose.
Claim 18
Dependent Claim
27 words
The composition of claim 1, further comprising a potable solvent in which the composition is dissolved to be in a form suitable for use in oral administration.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-09-22 | 1996-03-23 | 1996-09-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-09-22 | 2000-03-23 | 2000-09-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-09-22 | 2004-03-23 | 2004-09-22 | $7700.00 | Window Closed / Lapsed |