Patent US5217992A successfully refreshed from Google Patents.
US5217992A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders
Assignee: Siemens Healthcare Diagnostics GmbH Germany
•
Filing: 1990-09-17
•
Granted: 1993-06-08
•
Expires: 2010-09-17
Abstract
Abstract This invention relates to the use of tocotrienol, gamma-tocotrienol and delta-tocotrienol in reducing hypercholesterolemia, hyperlipidemia and thromboembolic disorders in mammals. [The isolation of these tocotrienols from natural sources and their chemical synthesis is disclosed.] The chemical synthesis of these tocotrienols is disclosed. The present invention also relates to prodrugs and pharmaceutical compositions of gamma-tocotrienol, delta-tocotrienol and tocotrienol and uses thereof.
Inventors
- 👤 John J. Wright
- 👤 Bradley C. Pearce
- 👤 Rex Parker
- 👤 Asaf A. Qureshi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 14:55
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/35; A61K31/352; A61K31/353; A61K31/355; A61P; A61P3/00; A61P3/06; A61P43/00; A61P7/00; A61P7/02; C; C07; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/58; C07D311/70; C07D311/72
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
44 words
A method of lowering the serum cholesterol levels in a bird or a mammal in need of a lowered serum cholesterol which comprises administering to such bird or mammal a safe and effective amount of substantially pure gamma-tocotrienol, substantially pure delta-tocotrienol, substantially pure tocotrienol.
Claim 2
Independent Claim
44 words
A method of lowering the serum cholesterol levels in a bird or a mammal in need of a lowered serum cholesterol which comprises administering to such bird or mammal a safe and effective amount of substantially pure gamma-tocotrienol, substantially pure delta-tocotrienol, substantially pure tocotrienol.
Claim 3
Independent Claim
43 words
A method of lowering the serum LDL-cholesterol levels in a bird or mammal in need of a lowered serum LDL-cholesterol which comprises administering to said bird or mammal a safe and effective amount of substantially pure gamma-tocotrienol, substantially pure delta-tocotrienol, substantially pure tocotrienol.
Claim 4
Independent Claim
43 words
A method of lowering the serum LDL-cholesterol levels in a bird or mammal in need of a lowered serum LDL-cholesterol which comprises administering to said bird or mammal a safe and effective amount of substantially pure gamma-tocotrienol, substantially pure delta-tocotrienol, substantially pure tocotrienol.
Claim 5
Independent Claim
42 words
A method of lowering the serum cholesterol levels in a bird or a mammal in need of a lowered serum cholesterol which comprises administering to such bird or mammal a safe and effective amount the ester prodrug of gamma-tocotrienol, delta-tocotrienol, or tocotrienol.
Claim 6
Independent Claim
42 words
A method of lowering the serum cholesterol levels in a bird or a mammal in need of a lowered serum cholesterol which comprises administering to such bird or mammal a safe and effective amount the ester prodrug of gamma-tocotrienol, delta-tocotrienol, or tocotrienol.
Claim 7
Independent Claim
43 words
A method of lowering the serum LDL-cholesterol levels in a bird or a mammal in need of a lowered serum LDL-cholesterol which comprises administering to said bird or mammal a safe and effective amount of the ester prodrug of gamma-tocotrienol, delta-tocotrienol, or tocotrienol.
Claim 8
Independent Claim
43 words
A method of lowering the serum LDL-cholesterol levels in a bird or a mammal in need of a lowered serum LDL-cholesterol which comprises administering to said bird or mammal a safe and effective amount of the ester prodrug of gamma-tocotrienol, delta-tocotrienol, or tocotrienol.
Claim 9
Independent Claim
18 words
The method of any one of claims 1 2, 5 or 6 wherein the tocotrienol is the d-isomer.
Claim 10
Independent Claim
20 words
The method of any one of claims 1 2, 5 or 6 wherein the tocotrienol is the d,l racemic mixture.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-06-07 | 1996-12-07 | 1997-06-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-06-07 | 2000-12-07 | 2001-06-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-06-07 | 2004-12-07 | 2005-06-08 | $7700.00 | Window Closed / Lapsed |