Patent US5322648A successfully refreshed from Google Patents.
US5322648A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for forming shaped collagen devices
Assignee: Vitaphore Corp
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Filing: 1991-08-26
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Granted: 1994-06-21
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Expires: 2011-08-26
Abstract
Abstract A method is provided for fabricating a shaped article from aqueous collagen-containing materials. A dispersion containing collagen and a surfactant is cast upon a mold of thermoplastic material and dried by a ramped drying profile under controlled conditions of relative humidity and temperature. The controlled drying allows for initial renaturation of the collagen dispersion then drying at high humidity to form a product with minimal residual stress.
Inventors
- 👤 Gregory S. Dapper
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 12:07
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; B; B29; B29C; B29C39/00; B29C39/003; B29C39/22; B29C39/42; B29D; B29D11/00; B29D11/00009; B29D11/00038; C; C08; C08L; C08L1/00; C08L1/08; C08L1/26; C08L1/28; C08L1/284; C08L89/00; C08L89/04; C08L89/06; A61F; A61F2/00; A61F2/02; A61F2/14; A61F2/16; A61F2310/00; A61F2310/00005; A61F2310/00365; B29K; B29K2089/00; B29K2901/00; B29K2901/12; C08L71/00; C08L71/02
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
147 words
A method for fabricating a transparent shaped article for ophthalmological use from aqueous collagen-containing materials whereby said article is made with minimal residual stress induced deformation from a predetermined shape defined by a mold upon which said article is formed by casting; comprising the steps of casting said aqueous collagen-containing materials upon said mold; preconditioning said materials by partially drying for a period sufficient to set said shape upon said mold at a temperature less than the temperature at which said collagen is denaturized and at a first relative humidity lower than about 80%; continuing the drying in a second relative humidity higher than said first relative humidity and in the range of about 80-99% at a temperature less than the temperature at which collagen is denaturized for a period of time sufficient to provide said shaped article in solid form with minimal residual stress induced deformation.
Claim 2
Independent Claim
147 words
A method for fabricating a transparent shaped article for ophthalmological use from aqueous collagen-containing materials whereby said article is made with minimal residual stress induced deformation from a predetermined shape defined by a mold upon which said article is formed by casting; comprising the steps of casting said aqueous collagen-containing materials upon said mold; preconditioning said materials by partially drying for a period sufficient to set said shape upon said mold at a temperature less than the temperature at which said collagen is denaturized and at a first relative humidity lower than about 80%; continuing the drying in a second relative humidity higher than said first relative humidity and in the range of about 80-99% at a temperature less than the temperature at which collagen is denaturized for a period of time sufficient to provide said shaped article in solid form with minimal residual stress induced deformation.
Claim 3
Dependent Claim
36 words
A method according to claim 1 further comprising the step of completely drying said shaped article at a temperature in the range of about 22°-27° C. at a relative humidity in the range of about 80-99%.
Claim 4
Dependent Claim
83 words
A method according to claim 1 comprising the steps of casting said aqueous collagen-containing materials upon said mold; partially drying said materials for a period of up to about four hours within the temperature range of 17° to 19° C. at a relative humidity within the range of 50% to 65%; continuing the drying for an additional period of up to three hours within the temperature range of 17° to 19° C. at a relative humidity within the range of 85% to 95%.
Claim 5
Dependent Claim
34 words
A method according to claim 3 comprising the step of completely drying said article within the temperature range of 22° to 27° C. at a relative humidity within the range of 90% to 95%.
Claim 6
Dependent Claim
22 words
A method according to claim 1, 2, 3 or 4 wherein the surface of said mold is made of a thermoplastic material.
Claim 7
Dependent Claim
21 words
A method according to claim 5 wherein said thermoplastic material is selected from the group consisting of polycarbonate, polyalkylene, and polyurethane.
Claim 8
Dependent Claim
12 words
A method according to claim 6 wherein said thermoplastic material comprises polycarbonate.
Claim 9
Dependent Claim
12 words
A method according to claim 6 wherein said thermoplastic material comprises polypropylene.
Claim 10
Dependent Claim
27 words
A method according to claim 5 wherein the surface wetting properties of said surface are selected to control the thickness of said materials cast upon said mold.
Claim 11
Dependent Claim
18 words
A method according to claim 1, 2, 3 or 4 wherein said collagen-containing materials further comprise a surfactant.
Claim 12
Dependent Claim
29 words
A method according to claim 10 wherein said surfactant is selected from the group consisting of hydroxyethyl cellulose, polyethylene glycol, polyvinylpyrrolidone, glycerin, polyvinyl alcohol, polyethylene polypropylene glycols and polysorbates.
Claim 13
Dependent Claim
12 words
A method according to claim 11 wherein said surfactant comprises hydroxyethyl cellulose.
Claim 14
Dependent Claim
13 words
A method according to claim 11 wherein said surfactant comprises polyethylene polypropylene glycols.
Claim 15
Dependent Claim
30 words
A method according to claim 10 wherein said surfactant and the amount thereof in said collagen-containing materials are selected to control the thickness of said materials cast upon said mold.
Claim 16
Dependent Claim
18 words
A method according to claim 1, 2, 3 or 4 wherein said article is an ophthalmic lenticular device.
Claim 17
Dependent Claim
15 words
A method according to claim 15 wherein said device is formed from bovine corium-derived collagen.
Claim 18
Dependent Claim
15 words
A method according to claim 15 wherein said article is formed from bovine tendon-derived collagen.
Claim 19
Dependent Claim
21 words
A method according to claim 1, 2, 3 or 4 further comprising the step of crosslinking said shaped article after drying.
Claim 20
Dependent Claim
13 words
A method according to claim 18 wherein said crosslinking is by dehydrothermal crosslinking.
Claim 21
Dependent Claim
13 words
A method according to claim 18 wherein said crosslinking is by ultraviolet radiation.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1997-06-20 | 1997-12-20 | 1998-06-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-06-20 | 2001-12-20 | 2002-06-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-06-20 | 2005-12-20 | 2006-06-21 | $7700.00 | Window Closed / Lapsed |