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US5330742A
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Methods and compositions for magnetic resonance imaging
Assignee: Mallinckrodt Inc
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Filing: 1992-04-03
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Granted: 1994-07-19
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Expires: 2012-04-03
Abstract
Abstract Methods and diagnostic compositions are disclosed for enhancing magnetic resonance imaging which utilize a paramagnetic metal cluster. Magnetic resonance contrast media containing Z+[Mn 12 X 12 (OYR) 16 (L) 4 ], where OYR is an oxyacid such as benzoic acid, acetic acid, methyl sulphonic acid, methyl phosphonic acid; L is a neutral donor such as water, alcohol, pyridine, or other amines; X is a chalcogen, such as O or S; and Z is a pharmaceutically acceptable counterion are disclosed. Z may also be a paramagnetic counter ion, such as a high spin metal cluster. The paramagnetic cluster may optionally be complexed or conjugated to a carrier compound capable of altering the paramagnetic metal cluster's biodistribution, increasing its selectivity of tumor localization, and amplifying its proton relaxivity.
Inventors
- 👤 Edward A. Deutsch
- 👤 Dennis A. Moore
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 23:47
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/18; A61K49/1818; A61K49/04; A61K49/0433; A61K49/1887; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
102 words
A method for obtaining magnetic resonance images of body organs and tissues which comprises: (a) administering to a mammal having organs and tissues, a diagnostically effective amount of a paramagnetic metal cluster of the formula Z+[Mn 12 X 12 (OYR) 16 (L) 4 ]-, where OYR is an oxyacid such as benzoic acid, acetic acid, methyl sulphonic acid, methyl phosphonic acid; L is a neutral donor such as water, alcohol, pyridine, or other amines; X is a chalcogen, such as O or S; and Z is a pharmaceutically acceptable counterion, in a pharmaceutically acceptable carrier; and (b) imaging the organs and tissues.
Claim 2
Independent Claim
102 words
A method for obtaining magnetic resonance images of body organs and tissues which comprises: (a) administering to a mammal having organs and tissues, a diagnostically effective amount of a paramagnetic metal cluster of the formula Z+[Mn 12 X 12 (OYR) 16 (L) 4 ]-, where OYR is an oxyacid such as benzoic acid, acetic acid, methyl sulphonic acid, methyl phosphonic acid; L is a neutral donor such as water, alcohol, pyridine, or other amines; X is a chalcogen, such as O or S; and Z is a pharmaceutically acceptable counterion, in a pharmaceutically acceptable carrier; and (b) imaging the organs and tissues.
Claim 3
Dependent Claim
23 words
A method for obtaining magnetic resonance images of body organs and tissues as defined in claim 1, wherein Z is a paramagnetic counterion.
Claim 4
Dependent Claim
41 words
A method for obtaining magnetic resonance images of body organs and tissues as defined in claim 2, wherein Z is [Mn 3 O(O 2 CR) 6 L 3 ]+, where R is Me or Ph and L is a neutral ligand.
Claim 5
Dependent Claim
31 words
A method for obtaining magnetic resonance images of body organs and tissues as defined in claim 2, wherein Z is [Mn 3 O(O 2 CMe) 6 (H 2 O) 3 ]+.
Claim 6
Dependent Claim
49 words
A method for obtaining magnetic resonance images of body organs and tissues as defined in claim 1, wherein the paramagnetic metal cluster is complexed or conjugated to a carrier compound capable of altering the paramagnetic metal cluster's biodistribution, increasing its selectivity of tumor localization, and amplifying its proton relaxivity.
Claim 7
Dependent Claim
25 words
A method for obtaining magnetic resonance images of body organs and tissues as defined in claim 5, wherein the carrier compound comprises a polymeric carrier.
Claim 8
Dependent Claim
25 words
A method for obtaining magnetic resonance images of body organs and tissues as defined in claim 5, wherein the carrier compound comprises a microspheric carrier.
Claim 9
Dependent Claim
25 words
A method for obtaining magnetic resonance images of body organs and tissues as defined in claim 5, wherein the carrier compound comprises a liposome carrier.
Claim 10
Dependent Claim
25 words
A method for obtaining magnetic resonance images of body organs and tissues as defined in claim 5, wherein the carrier compound comprises a hydroxyapatite carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-07-18 | 1998-01-17 | 1998-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-07-18 | 2002-01-17 | 2002-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-07-18 | 2006-01-17 | 2006-07-19 | $7700.00 | Window Closed / Lapsed |