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US5338872A
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Process for the preparation of 10-desacetoxybaccatin III and 10-desacetoxytaxol and derivatives thereof
Assignee: Florida State University
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Filing: 1993-01-15
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Granted: 1994-08-16
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Expires: 2013-01-15
Abstract
Abstract A process for the preparation of a 10-desacetoxy and 10-desoxy tetracyclic taxane in which a tetracyclic taxane having a C10 hydroxy or acetoxy substituent is reacted with samarium diiodide.
Inventors
- 👤 Robert A. Holton
- 👤 Carmen Somoza
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 23:25
CPC Classifications
C; C07; C07D; C07D409/00; C07D409/02; C07D409/12; C07D305/00; C07D305/14; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/18; C07F7/1804
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
32 words
A process for the preparation of a 10-desacetoxy or 10-desoxy tetracyclic taxane comprising reacting a tetracyclic taxane having a C9 keto substituent and a C10 hydroxy or acetoxy substituent with samarium diiodide.
Claim 2
Dependent Claim
32 words
A process for the preparation of a 10-desacetoxy or 10-desoxy tetracyclic taxane comprising reacting a tetracyclic taxane having a C9 keto substituent and a C10 hydroxy or acetoxy substituent with samarium diiodide.
Claim 3
Dependent Claim
14 words
The process of claim 1 wherein the tetracyclic taxane has a C10 hydroxy substituent.
Claim 4
Dependent Claim
14 words
The process of claim 1 wherein the tetracyclic taxane has a C10 acetoxy substituent.
Claim 5
Dependent Claim
21 words
The process of claim 1 wherein the tetracyclic taxane has the formula ##STR7## wherein ph is phenyl and Ac is acetyl.
Claim 6
Dependent Claim
21 words
The process of claim 1 wherein the tetracyclic taxane has the formula ##STR8## wherein Ph is phenyl and Ac is acetyl.
Claim 7
Dependent Claim
24 words
The process of claim 1 wherein the tetracyclic taxane has the formula ##STR9## wherein tBu is tert-butyl, Ph is phenyl and Ac is acetyl.
Claim 8
Dependent Claim
17 words
The process of claim 1 wherein the tetracyclic taxane has the formula ##STR10## wherein Ac is acetyl.
Claim 9
Dependent Claim
19 words
A process as set forth in claim 1 wherein the reaction is carried out at 0° C. in tetrahydrofuran.
Claim 10
Dependent Claim
19 words
A process as set forth in claim 4 wherein the reaction is carried out at 0° C. in tetrahydrofuran.
Claim 11
Dependent Claim
19 words
A process as set forth in claim 5 wherein the reaction is carried out at 0° C. in tetrahydrofuran.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-08-15 | 1998-02-14 | 1998-08-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-08-15 | 2002-02-14 | 2002-08-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-08-15 | 2006-02-14 | 2006-08-16 | $7700.00 | Window Closed / Lapsed |