Patent US5387327A successfully refreshed from Google Patents.
US5387327A
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US
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Implantable non-enzymatic electrochemical glucose sensor
Assignee: Duquesne University of the Holy Spirit
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Filing: 1992-10-19
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Granted: 1995-02-07
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Expires: 2012-10-19
Abstract
Abstract A non-enzymatic implantable glucose blood detector. The detector makes use of a non-reactive tin oxide semiconductor measurement electrode which is suitably energized by an electrical power source. Variations in current density at the measurement electrode are related to variations in glucose content of blood. The device also uses variable voltage to allow the electrode to be self-cleaning.
Inventors
- 👤 Shahed U. M. Khan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 23:46
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14532; A61B5/1468; A61B5/1473; A61B5/48; A61B5/4836; A61B5/4839; A61M; A61M5/00; A61M5/14; A61M5/168; A61M5/172; A61M5/1723
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
153 words
An implantable unit adapted for delivering insulin in response to detection of blood glucose levels exceeding a predetermined set point, said unit comprising a non-reactive semiconductor measurement electrode, said electrode energized by an electrical power source and disposed within a sleeve member having an opening permitting glucose molecules to pass therethrough to said measurement electrode, but resisting the passage therethrough of molecules of predetermined greater size, said measurement electrode being connected to monitoring means for monitoring current density at said measurement electrode, in response to glucose molecules oxidation or glucose molecules reduction reactions at said measurement electrode, said monitored current density being translated into a blood glucose level by said monitoring means, said unit further including an insulin reservoir and insulin pump for delivering insulin from said reservoir to a patient in response to a signal from said monitoring means that the blood glucose level of said patient has exceeded said set point.
Claim 2
Dependent Claim
153 words
An implantable unit adapted for delivering insulin in response to detection of blood glucose levels exceeding a predetermined set point, said unit comprising a non-reactive semiconductor measurement electrode, said electrode energized by an electrical power source and disposed within a sleeve member having an opening permitting glucose molecules to pass therethrough to said measurement electrode, but resisting the passage therethrough of molecules of predetermined greater size, said measurement electrode being connected to monitoring means for monitoring current density at said measurement electrode, in response to glucose molecules oxidation or glucose molecules reduction reactions at said measurement electrode, said monitored current density being translated into a blood glucose level by said monitoring means, said unit further including an insulin reservoir and insulin pump for delivering insulin from said reservoir to a patient in response to a signal from said monitoring means that the blood glucose level of said patient has exceeded said set point.
Claim 3
Dependent Claim
22 words
The detector of claim 1, wherein said power source creates a continuous variable voltage, thereby maintaining said electrode in a clean state.
Claim 4
Dependent Claim
28 words
The detector of claim 1, wherein said non-reactive semiconductor measurement electrode is fabricated from a semiconductor material selected from the group consisting of tin oxide and titanium dioxide.
Claim 5
Dependent Claim
35 words
The detector of claim 3, wherein said sleeve member comprises a venturi tube having an opening for allowing said glucose molecules to pass therethrough but precludes passage therethrough of molecules larger than about 100,000 M.W.
Claim 6
Dependent Claim
157 words
An implantable unit adapted for delivering insulin in response to detection of blood glucose levels exceeding a predetermined set point, said unit comprising a non-reactive semiconductor electrode, said electrode energized by an electrical power source and disposed within a sleeve member having an opening covered with a biocompatible membrane having a pore size permitting glucose molecules to pass therethrough to said electrode, but resisting the passage therethrough of molecules sized greater than about 100,000 M.W., said electrode being connected to monitoring means for monitoring current density at said electrode, in response to glucose oxidation or glucose reduction reactions at said electrode, said monitored current density being translated into a blood glucose level by said monitoring means, said unit further including an insulin reservoir and insulin pump for delivering insulin from said reservoir to a patient in response to a signal from said monitoring means that the blood glucose level of said patient has exceeded said set point.
Claim 7
Dependent Claim
157 words
An implantable unit adapted for delivering insulin in response to detection of blood glucose levels exceeding a predetermined set point, said unit comprising a non-reactive semiconductor electrode, said electrode energized by an electrical power source and disposed within a sleeve member having an opening covered with a biocompatible membrane having a pore size permitting glucose molecules to pass therethrough to said electrode, but resisting the passage therethrough of molecules sized greater than about 100,000 M.W., said electrode being connected to monitoring means for monitoring current density at said electrode, in response to glucose oxidation or glucose reduction reactions at said electrode, said monitored current density being translated into a blood glucose level by said monitoring means, said unit further including an insulin reservoir and insulin pump for delivering insulin from said reservoir to a patient in response to a signal from said monitoring means that the blood glucose level of said patient has exceeded said set point.
Claim 8
Dependent Claim
22 words
The detector of claim 5, wherein said power source creates a continuous variable voltage, thereby maintaining said electrode in a clean slate.
Claim 9
Dependent Claim
27 words
The detector of claim 5, wherein said non-reactive semiconductor electrode is fabricated from a semiconductor material selected from the group consisting of tin oxide and titanium dioxide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1998-02-06 | 1998-08-08 | 1999-02-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-02-06 | 2002-08-08 | 2003-02-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-02-06 | 2006-08-08 | 2007-02-07 | $7700.00 | Window Closed / Lapsed |