Patent US5401239A successfully refreshed from Google Patents.
US5401239A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Electromotive treatment of catheter-rerelated infections
Assignee: Physion Srl
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Filing: 1993-03-11
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Granted: 1995-03-28
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Expires: 2013-03-11
Abstract
Abstract A method of treating recalcitrant indewelling catheter-associated infections including the following procedures: inserting into the lumen of the catheter, a primary electrode whose uninsulated distal section is of a spiral or filamentous configuration physically contacting the internal surface of the catheter; positioning and sealing a secondary electrode-receptacle on the skin area around the exit site of the catheter and around an external section of the catheter so as to form a conical container for holding liquids; infusion of a solution of antimicrobial drugs through the catheter; instilling a solution of antimicrobial drugs into the secondary electrode-receptacle; and applying a voltage differential between the primary and secondary electrodes, in which an electric field is applied to the internal and external surfaces of the catheter, and this field both disrupts hitherto priviledged sites for microorganisms on the surfaces of the catheter and drives antimicrobial drugs into these same surfaces.
Inventors
- 👤 Robert L. Stephen
- 👤 Cino Rossi
- 👤 Silvio Eruzzi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 16:00
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/20; A61N1/30
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
146 words
A method of treating indwelling catheter-based infections which comprises the steps of: providing two access ports on an exiting end at a catheter which exits from a bodily area; inserting into said indwelling catheter, through one said access port, a primary electrode; positioning a secondary electrode-receptacle on a skin area around the exit site of the catheter so as to surround at least a portion of said exiting end of the catheter, so as to form a receptacle for holding liquids; infusing an aqueous solution through a second one of said access ports and through said catheter; instilling an aqueous solution of an antimicrobial drug into said secondary electrode receptacle; and applying a voltage differential between said primary and secondary electrode, whereby an electric field is applied to both internal and external surfaces of the catheter to drive any antimicrobial drug into contact with such surfaces.
Claim 2
Independent Claim
146 words
A method of treating indwelling catheter-based infections which comprises the steps of: providing two access ports on an exiting end at a catheter which exits from a bodily area; inserting into said indwelling catheter, through one said access port, a primary electrode; positioning a secondary electrode-receptacle on a skin area around the exit site of the catheter so as to surround at least a portion of said exiting end of the catheter, so as to form a receptacle for holding liquids; infusing an aqueous solution through a second one of said access ports and through said catheter; instilling an aqueous solution of an antimicrobial drug into said secondary electrode receptacle; and applying a voltage differential between said primary and secondary electrode, whereby an electric field is applied to both internal and external surfaces of the catheter to drive any antimicrobial drug into contact with such surfaces.
Claim 3
Dependent Claim
39 words
A method of treatment according to claim 1, wherein the step of inserting said primary electrode includes moving said primary electrode inside said catheter so as to mechanically disrupt any film deposit on the internal surface of the catheter.
Claim 4
Dependent Claim
36 words
A method of treatment according to claim 2, wherein the catheter associated infections are caused by microorganisms residing within priviledged sites which are attached to, and are within, the internal and external surface of said catheter.
Claim 5
Dependent Claim
34 words
A method of treatment according to claim 1, wherein said solution infused into said indwelling catheter comprises an ionized antimicrobial drug at a concentration greater than or equal to 0.50% w/v, in distilled water.
Claim 6
Dependent Claim
33 words
A method of treatment according to claim 1, wherein said solution infused into said indwelling catheter comprises an ionized antimicrobial drug at a concentration less than 0.50% w/v in a physiological electrolyte solution.
Claim 7
Dependent Claim
26 words
A method of treatment according to claim 1, wherein said solution infused into said indwelling catheter comprises a non-ionized antimicrobial drug in a physiological electrolyte solution.
Claim 8
Dependent Claim
34 words
A method of treatment according to claim 1, wherein said solution instilled into the secondary electrode-receptacle comprises an ionized antimicrobial drug at a concentration greater than or equal to 0.50% w/v, in distilled water.
Claim 9
Dependent Claim
33 words
A method of treatment according to claim 1, wherein said solution instilled into the secondary electrode-receptacle comprises an ionized antimicrobical drug at a concentration less than 0.50% w/v in a physiological electrolyte solution.
Claim 10
Dependent Claim
27 words
A method of treatment according to claim 1, wherein said solution instilled into said secondary electrode-receptacle comprises a non ionized antimicrobial drug in a physiological electrolyte solution.
Claim 11
Dependent Claim
41 words
A method of treatment according to claim 1, associated with systemic administration of antimicrobial drugs, wherein said aqueous solution infused through said indwelling catheter comprises non ionized solutes selected from glucose, mannitol, and glycine, in a concentration ranging from 3-5% w/v.
References Cited (Backward Citations)
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