US5409666A
Expired / Lapsed
US
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Sensors and methods for sensing
Assignee: Terumo Cardiovascular Systems Corp
•
Filing: 1993-10-14
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Granted: 1995-04-25
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Expires: 2013-10-14
Abstract
Abstract A sensor for measuring the concentration of an analyte in a medium is disclosed. In one embodiment, the sensor comprises a sensing element including a matrix material and, covalently bonded thereto, one or more monomeric indicator components each of which is capable of providing a first emitted signal of a given wavelength in response to being exposed to an excitation signal. The sensing element is capable of providing a second emitted signal having a longer wavelength than the first emitted signal or signals in response to being exposed to the excitation signal, the second emitted signal being provided by an excimer component produced in the sensing element from the monomeric indicator component(s) and being dependent on the concentration of the analyte in the medium to a greater extent than the first emitted signal or signals. In another embodiment, the sensor comprises a sensing element including two or more different monomeric components at least one of which is a monomeric indicator component capable of providing a first emitted signal in response to being exposed to a first excitation signal. The sensing element is capable of providing a second emitted signal in response to being exposed to a second excitation signal. This second emitted signal is provided by an exciplex produced from the monomeric components. This second emitted signal is preferably dependent on the concentration of the analyte in the medium. An excitation assembly is positioned and adapted to provide the excitation signal to the sensing element. A detector assembly is positioned and adapted to detect the second emitted signal. Preferably, a processor assembly is positioned and adapted to analyze the second emitted signal in determining the concentration of the analyte in the medium.
Inventors
- 👤 Colleen C. Nagel
- 👤 James G. Bentsen
- 👤 John L. Dektar
- 👤 Cary A. Kipke
- 👤 Masao Yafuso
- 👤 Alan R. Katritzky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 05:00
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/75; G01N21/77; G01N21/7703; A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/1459; C; C07; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/0834; C07F7/0838; C08; C08G; C08G77/00; C08G77/04; C08G77/38; G01N21/62; G01N21/63; G01N21/64; G01N21/6428; G01N31/00; G01N31/22; G01N31/223; G01N31/225; G01N2021/6434; G01N2021/7706; G01N2021/772; G01N2021/773; G01N2021/7769; G01N2021/7786; Y; Y10; Y10S; Y10S436/00; Y10S436/80; Y10S436/805; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
202 words
A composition for measuring the concentration of an analyte in a medium comprising: a solid matrix material which is permeable to said analyte in said medium; and an indicator component in said matrix material comprising at least two monomeric components in enforced association, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said composition further comprising, when exposed to said first excitation signal, an excited state complex produced from said at least two monomeric components, said excited state complex providing a second emitted signal which is dependent on the concentration of said analyte in said medium, wherein said monomeric components in enforced association are selected from the group consisting of intramolecular excited state complex forming molecules dispersed in a matrix material, intramolecular excited state complex forming molecules covalently attached, adsorbed or otherwise attached to the surface of a matrix material, intramolecular excited state complex forming molecules covalently attached to a matrix material, monomeric component aggregates covalently attached to a matrix material, monomeric component aggregates adsorbed to the surface of a matrix material, an inclusion complex comprising a supra-molecule, and ionically bound monomeric components.
Claim 2
Dependent Claim
202 words
A composition for measuring the concentration of an analyte in a medium comprising: a solid matrix material which is permeable to said analyte in said medium; and an indicator component in said matrix material comprising at least two monomeric components in enforced association, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said composition further comprising, when exposed to said first excitation signal, an excited state complex produced from said at least two monomeric components, said excited state complex providing a second emitted signal which is dependent on the concentration of said analyte in said medium, wherein said monomeric components in enforced association are selected from the group consisting of intramolecular excited state complex forming molecules dispersed in a matrix material, intramolecular excited state complex forming molecules covalently attached, adsorbed or otherwise attached to the surface of a matrix material, intramolecular excited state complex forming molecules covalently attached to a matrix material, monomeric component aggregates covalently attached to a matrix material, monomeric component aggregates adsorbed to the surface of a matrix material, an inclusion complex comprising a supra-molecule, and ionically bound monomeric components.
Claim 3
Dependent Claim
17 words
A composition according to claim 1, wherein said monomeric components in enforced association are covalently bonded together.
Claim 4
Dependent Claim
25 words
A composition according to claim 1, wherein said at least two monomeric components are different and said produced excited state complex is an exciplex component.
Claim 5
Dependent Claim
18 words
A composition according to claim 1, wherein said indicator component is covalently bonded to said solid matrix material.
Claim 6
Dependent Claim
126 words
A composition for measuring the concentration of an analyte in a medium comprising: a solid matrix material which is permeable to said analyte in said medium; and at least two different monomeric components, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said composition further comprising, when exposed to said excitation signal, an exciplex component produced from said monomeric components, said exciplex component providing a second emitted signal, said second signal being dependent on the concentration of said analyte in said medium, and wherein a total integrated intensity at the wavelength of the detected second emitted signal has less than ten percent contribution due to monomer emission.
Claim 7
Dependent Claim
126 words
A composition for measuring the concentration of an analyte in a medium comprising: a solid matrix material which is permeable to said analyte in said medium; and at least two different monomeric components, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said composition further comprising, when exposed to said excitation signal, an exciplex component produced from said monomeric components, said exciplex component providing a second emitted signal, said second signal being dependent on the concentration of said analyte in said medium, and wherein a total integrated intensity at the wavelength of the detected second emitted signal has less than ten percent contribution due to monomer emission.
Claim 8
Dependent Claim
15 words
A composition according to claim 5, wherein said solid matrix material comprises an addition-cure silicone.
Claim 9
Dependent Claim
14 words
A composition according to claim 5, wherein said monomeric components are covalently bonded together.
Claim 10
Dependent Claim
18 words
A composition according to claim 5, wherein said indicator component is covalently bonded to said solid matrix material.
Claim 11
Dependent Claim
115 words
A composition for measuring the concentration of an analyte in a medium comprising: a solid matrix material which is permeable to said analyte in said medium; and at least two different monomeric components, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said composition further comprising, when exposed to said excitation signal, an exciplex component produced from said monomeric components, said exciplex component providing a second emitted signal and being dependent on the concentration of said analyte in said medium, wherein at least one of said monomeric components is covalently bonded to said solid matrix material.
Claim 12
Dependent Claim
115 words
A composition for measuring the concentration of an analyte in a medium comprising: a solid matrix material which is permeable to said analyte in said medium; and at least two different monomeric components, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said composition further comprising, when exposed to said excitation signal, an exciplex component produced from said monomeric components, said exciplex component providing a second emitted signal and being dependent on the concentration of said analyte in said medium, wherein at least one of said monomeric components is covalently bonded to said solid matrix material.
Claim 13
Dependent Claim
15 words
A composition according to claim 9, wherein said solid matrix material comprises an addition-cure silicone.
Claim 14
Dependent Claim
14 words
A composition according to claim 9, wherein said monomeric components are covalently bonded together.
Claim 15
Dependent Claim
19 words
A composition according to claim 9, wherein at least one of said monomeric components is a monomeric non-indicator component.
Claim 16
Dependent Claim
161 words
A sensor for measuring the concentration of an analyte in a medium comprising: a sensing element comprising an analyte permeable matrix material and at least two different monomeric components in enforced association, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, and wherein at least one of said monomeric components is covalently bonded to said matrix material, said sensing element further comprising, when exposed to said excitation signal, an exciplex component produced from said monomeric components, said exciplex component providing a second emitted signal and being dependent on the concentration of said analyte in said medium; an excitation assembly which provides said excitation signal to said sensing element; a detector assembly which detects said second emitted signal provided by said sensing element; and a processor assembly which analyzes said second emitted signal in determining the concentration of said analyte in said medium.
Claim 17
Dependent Claim
161 words
A sensor for measuring the concentration of an analyte in a medium comprising: a sensing element comprising an analyte permeable matrix material and at least two different monomeric components in enforced association, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, and wherein at least one of said monomeric components is covalently bonded to said matrix material, said sensing element further comprising, when exposed to said excitation signal, an exciplex component produced from said monomeric components, said exciplex component providing a second emitted signal and being dependent on the concentration of said analyte in said medium; an excitation assembly which provides said excitation signal to said sensing element; a detector assembly which detects said second emitted signal provided by said sensing element; and a processor assembly which analyzes said second emitted signal in determining the concentration of said analyte in said medium.
Claim 18
Dependent Claim
17 words
A sensor according to claim 13, wherein said monomeric components in enforced association are covalently bonded together.
Claim 19
Dependent Claim
46 words
A sensor according to claim 13, wherein said processor assembly determines an intensity ratio of said second emitted signal to said first emitted signal or to one of said first emitted signals, said intensity ratio being dependent on the concentration of said analyte in said medium.
Claim 20
Dependent Claim
168 words
A sensor for measuring the concentration of an analyte in a medium comprising: a sensing element comprising an analyte permeable matrix material and at least two different monomeric components at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said sensing element further comprising, when exposed to said excitation signal, an exciplex component produced from said monomeric components, said exciplex component providing a second emitted signal, said second signal being dependent on the concentration of said analyte in said medium, and wherein a total integrated intensity at the wavelength of the second emitted signal has less than ten percent contribution due to monomer emission; an excitation assembly which provides said excitation signal to said sensing element; a detector assembly which detects said second emitted signal provided by said sensing element; and a processor assembly which analyzes said second emitted signal in determining the concentration of said analyte in said medium.
Claim 21
Dependent Claim
168 words
A sensor for measuring the concentration of an analyte in a medium comprising: a sensing element comprising an analyte permeable matrix material and at least two different monomeric components at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said sensing element further comprising, when exposed to said excitation signal, an exciplex component produced from said monomeric components, said exciplex component providing a second emitted signal, said second signal being dependent on the concentration of said analyte in said medium, and wherein a total integrated intensity at the wavelength of the second emitted signal has less than ten percent contribution due to monomer emission; an excitation assembly which provides said excitation signal to said sensing element; a detector assembly which detects said second emitted signal provided by said sensing element; and a processor assembly which analyzes said second emitted signal in determining the concentration of said analyte in said medium.
Claim 22
Dependent Claim
24 words
A sensor according to claim 8, wherein said sensing element comprises an indicator component comprising at least two monomeric components are covalently bonded together.
Claim 23
Dependent Claim
19 words
A sensor according to claim 8, wherein said monomeric indicator component is covalently bonded to said solid matrix material.
Claim 24
Dependent Claim
168 words
A sensor for measuring the concentration of an analyte in a medium comprising: a sensing element comprising an analyte permeable matrix material and at least two monomeric components at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, and wherein at least one of said monomeric components is covalently bonded to said matrix material, said sensing element further comprising, when exposed to said excitation signal, an excited state complex produced from said monomeric components, said excited state complex providing a second emitted signal having a longer wavelength than said first emitted signal and being dependent on the concentration of said analyte in said medium; an excitation assembly which provides said excitation signal to said sensing element; a detector assembly which detects said second emitted signal provided by said sensing element; and a processor assembly which analyzes said second emitted signal in determining the concentration of said analyte in said medium.
Claim 25
Dependent Claim
168 words
A sensor for measuring the concentration of an analyte in a medium comprising: a sensing element comprising an analyte permeable matrix material and at least two monomeric components at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, and wherein at least one of said monomeric components is covalently bonded to said matrix material, said sensing element further comprising, when exposed to said excitation signal, an excited state complex produced from said monomeric components, said excited state complex providing a second emitted signal having a longer wavelength than said first emitted signal and being dependent on the concentration of said analyte in said medium; an excitation assembly which provides said excitation signal to said sensing element; a detector assembly which detects said second emitted signal provided by said sensing element; and a processor assembly which analyzes said second emitted signal in determining the concentration of said analyte in said medium.
Claim 26
Dependent Claim
23 words
A sensor according to claim 19, wherein said sensing element comprises an indicator component comprising at least two monomeric components covalently bonded together.
Claim 27
Dependent Claim
25 words
A sensor according to claim 19, wherein said at least two monomeric components are different and said produced excited state complex is an exciplex component.
Claim 28
Dependent Claim
108 words
A composition for measuring the concentration of an analyte in a medium comprising: a tethered indicator component comprising at least two monomeric components, at least one of which is a monomeric indicator component capable of providing a first emitted signal or signals in response to being exposed to a first excitation signal, and at least one allyl moiety suitable for being covalently attached to a polysiloxane matrix material, said composition further comprising, when exposed to said excitation signal, an excited state complex produced from said monomeric components, said excited state complex providing a second emitted signal and being dependent on the concentration of said analyte in said medium.
Claim 29
Dependent Claim
108 words
A composition for measuring the concentration of an analyte in a medium comprising: a tethered indicator component comprising at least two monomeric components, at least one of which is a monomeric indicator component capable of providing a first emitted signal or signals in response to being exposed to a first excitation signal, and at least one allyl moiety suitable for being covalently attached to a polysiloxane matrix material, said composition further comprising, when exposed to said excitation signal, an excited state complex produced from said monomeric components, said excited state complex providing a second emitted signal and being dependent on the concentration of said analyte in said medium.
Claim 30
Dependent Claim
33 words
A composition according to claim 22, wherein said composition is the reaction product of a chloromethyl derivative of said monomeric component with an anion selected from the group consisting of malonates and cyanoacetates.
Claim 31
Dependent Claim
17 words
A composition according to claim 2, wherein said monomeric components are linked by less than 20 atoms.
Claim 32
Dependent Claim
19 words
A composition according to claim 2, wherein said monomeric components are linked by between 2 and 7 carbon atoms.
Claim 33
Dependent Claim
17 words
A composition according to claim 7, wherein said monomeric components are linked by less than 20 atoms.
Claim 34
Dependent Claim
17 words
A composition according to claim 11 wherein said monomeric components are linked by less than 20 atoms.
Claim 35
Dependent Claim
17 words
A sensor according to claim 17, wherein said monomeric components are linked by less than 20 atoms.
Claim 36
Dependent Claim
17 words
A sensor according to claim 20, wherein said monomeric components are linked by less than 20 atoms.
Claim 37
Dependent Claim
17 words
A composition according to claim 22, wherein said monomeric components are linked by less than 20 atoms.
Claim 38
Dependent Claim
19 words
A composition according to claim 22, wherein said monomeric components are linked by between 2 and 7 carbon atoms.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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