Patent US5409703A successfully refreshed from Google Patents.
US5409703A
Expired / Lapsed
US
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Dried hydrogel from hydrophilic-hygroscopic polymer
Assignee: Ology Bioservices Inc
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Filing: 1993-06-24
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Granted: 1995-04-25
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Expires: 2013-06-24
Abstract
Abstract A therapeutic medical device is described that is comprised of a dried hydrogel of a hydrophilic-hygroscopic polymer, such as an unmodified or modified polymeric carbohydrate, in the form of a solid foam. The dried hydrogel is prepared by preferably freeze-drying a hydrogel of this polymer in a liquid medium, such as water. The dried hydrogel can be sterilized by radiation or other means so that the sterilized product has a relatively indefinite shelf-life without refrigeration. The resultant dried hydrogel can be transformed into a hydrogel upon absorption of addition liquid medium. The described therapeutic device can serve as a dressing for a wound or lesion, drug delivery system, a hemostatic agent and a biologic response modifier. The described therapeutic device enhances the wound healing rate.
Inventors
- 👤 Bill H. McAnalley
- 👤 Stephen Boyd
- 👤 Robert H. Carpenter
- 👤 John E. Hall
- 👤 Judith St. John
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 12:23
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0061; A61L26/0085; A61F; A61F13/00; A61F13/02; A61F13/0203; A61F13/0206; A61F13/0209; A61K; A61K36/00; A61K36/18; A61K36/88; A61K36/886; A61L15/00; A61L15/16; A61L15/22; A61L15/28; A61L15/42; A61L15/60; A61L26/0009; A61L26/0023; A61L26/008
Claims Analysis
Total Claims: 77
Claim 1
Independent Claim
86 words
A therapeutic device comprising a dried hydrogel in the form of a flexible solid foam that can be cut to the shape of a wound or lesion, said therapeutic device having gas bubbles dispersed throughout and being prepared by removing a liquid medium from a hydrogel, said hydrogel comprising particles of a hydrophilic-hygroscopic therapeutic polysaccharide dispersed in said liquid medium, wherein said therapeutic polysaccharide is obtained from aloe vera, said therapeutic device being capable of being transformed into said hydrogel upon absorption of additional liquid medium.
Claim 2
Dependent Claim
86 words
A therapeutic device comprising a dried hydrogel in the form of a flexible solid foam that can be cut to the shape of a wound or lesion, said therapeutic device having gas bubbles dispersed throughout and being prepared by removing a liquid medium from a hydrogel, said hydrogel comprising particles of a hydrophilic-hygroscopic therapeutic polysaccharide dispersed in said liquid medium, wherein said therapeutic polysaccharide is obtained from aloe vera, said therapeutic device being capable of being transformed into said hydrogel upon absorption of additional liquid medium.
Claim 3
Dependent Claim
15 words
The therapeutic device as in claim 1, wherein said liquid medium comprises a polar solvent.
Claim 4
Dependent Claim
13 words
The therapeutic device as in claim 1, wherein said liquid medium comprises water.
Claim 5
Dependent Claim
19 words
The therapeutic device as in claim 1, wherein said liquid medium is removed from said hydrogel by freeze drying.
Claim 6
Dependent Claim
18 words
The therapeutic device as in claim 1, wherein said hydrophilic-hygroscopic therapeutic polysaccharide obtained from aloe vera comprises acemannan.
Claim 7
Dependent Claim
23 words
The therapeutic device of claim 1, wherein said liquid medium comprises from about 5% to about 15% by weight of said therapeutic device.
Claim 8
Dependent Claim
24 words
The therapeutic device of claim 1, wherein said hydrophilic-hygroscopic therapeutic polysaccharide comprises from about 85% to about 95% by weight of said therapeutic device.
Claim 9
Dependent Claim
22 words
The therapeutic device of claim 1, wherein said therapeutic device has a density of from about 0.002 g/cc to about 0.04 g/cc.
Claim 10
Dependent Claim
22 words
The therapeutic device of claim 1, wherein said therapeutic device has a density of from about 0.02 g/cc to about 0.03 g/cc.
Claim 11
Dependent Claim
11 words
The therapeutic device as in claim 1, further comprising an antibiotic.
Claim 12
Dependent Claim
21 words
The therapeutic device as in claim 10, wherein said antibiotic is selected from the group consisting of tetracycline, oxytetracycline, and gentamycin.
Claim 13
Dependent Claim
12 words
The therapeutic device as in claim 1, further comprising a pharmaceutical agent.
Claim 14
Dependent Claim
14 words
The therapeutic device as in claim 12, wherein said pharmaceutical agent comprises an antihistamine.
Claim 15
Dependent Claim
28 words
The therapeutic device as in claim 12, wherein said pharmaceutical agent is selected from the group consisting of an anticancer agent, an antiviral agent, and an antifungal agent.
Claim 16
Dependent Claim
11 words
The therapeutic device as in claim 1, further comprising a biologic.
Claim 17
Dependent Claim
23 words
The therapeutic device as in claim 15, wherein said biologic is selected from the group consisting of a hormone and a growth factor.
Claim 18
Dependent Claim
12 words
The therapeutic device as in claim 1, further comprising a hemostatic agent.
Claim 19
Dependent Claim
11 words
The therapeutic device as in claim 1, further comprising a microorganism.
Claim 20
Dependent Claim
12 words
The-therapeutic device as in claim 18, wherein said microorganism comprises a vaccine.
Claim 21
Dependent Claim
15 words
The therapeutic device as in claim 19, wherein said vaccine comprises a modified live virus.
Claim 22
Dependent Claim
14 words
The therapeutic device as in claim 19, wherein said vaccine comprises a killed virus.
Claim 23
Dependent Claim
13 words
The therapeutic device as in claim 19, wherein said vaccine comprises vital components.
Claim 24
Dependent Claim
11 words
The therapeutic device as in claim 1, further comprising a preservative.
Claim 25
Dependent Claim
21 words
The therapeutic device as in claim 23, wherein said preservative is selected from the group consisting of methylparaben and benzethonium chloride.
Claim 26
Dependent Claim
12 words
The therapeutic device as in claim 1, further comprising a topical anesthetic.
Claim 27
Dependent Claim
12 words
The therapeutic device as in claim 1, further comprising a metal ion.
Claim 28
Dependent Claim
23 words
The therapeutic device as in claim 26, wherein said metal ion is selected from the group consisting of zinc, cobalt, iron, and manganese.
Claim 29
Dependent Claim
24 words
The therapeutic device as in claim 1, wherein said hydrogel comprises: about 99% by weight of water, and about 0.6% by weight of acemannan.
Claim 30
Dependent Claim
15 words
The therapeutic device as in claim 1, wherein said therapeutic device is sterilized by radiation.
Claim 31
Dependent Claim
91 words
A therapeutic device comprising a dried-hydrogel in the form of a flexible solid foam that can be cut to the shape of a wound or lesion, said therapeutic device having gas bubbles dispersed throughout and being prepared by freeze-drying a hydrogel comprising: about 98.88% by weight of purified water, about 0.5% by weight of plasdone, about 0.002% by weight of benzethonium chloride, about 0.05% by weight of acemannan, and about 0.445% by weight of hydroxyethylcellulose, said therapeutic device being capable of being transformed into said hydrogel upon absorption of additional water.
Claim 32
Dependent Claim
91 words
A therapeutic device comprising a dried-hydrogel in the form of a flexible solid foam that can be cut to the shape of a wound or lesion, said therapeutic device having gas bubbles dispersed throughout and being prepared by freeze-drying a hydrogel comprising: about 98.88% by weight of purified water, about 0.5% by weight of plasdone, about 0.002% by weight of benzethonium chloride, about 0.05% by weight of acemannan, and about 0.445% by weight of hydroxyethylcellulose, said therapeutic device being capable of being transformed into said hydrogel upon absorption of additional water.
Claim 33
Dependent Claim
15 words
The therapeutic device as in claim 30, wherein said therapeutic device is sterilized by radiation.
Claim 34
Dependent Claim
82 words
A therapeutic device comprising from about 85% to about 95% by weight of a hydrophilic-hygroscopic therapeutic polysaccharide obtained from aloe vera dispersed in from about 5% to about 15% by weight of liquid medium, said therapeutic device being in the form of a flexible solid foam that can be cut to the shape of a wound or lesion, and said therapeutic device having gas bubbles dispersed throughout and being capable of being transformed into a hydrogel upon absorption of additional liquid medium.
Claim 35
Dependent Claim
82 words
A therapeutic device comprising from about 85% to about 95% by weight of a hydrophilic-hygroscopic therapeutic polysaccharide obtained from aloe vera dispersed in from about 5% to about 15% by weight of liquid medium, said therapeutic device being in the form of a flexible solid foam that can be cut to the shape of a wound or lesion, and said therapeutic device having gas bubbles dispersed throughout and being capable of being transformed into a hydrogel upon absorption of additional liquid medium.
Claim 36
Dependent Claim
24 words
The therapeutic device as in claim 32, wherein said liquid medium comprises from about 8% to about 12% by weight of said therapeutic device.
Claim 37
Dependent Claim
20 words
The therapeutic device as in claim 32, wherein said liquid medium comprises about 10% by weight of said therapeutic device.
Claim 38
Dependent Claim
18 words
The therapeutic device as in claim 32, wherein said hydrophilic-hygroscopic therapeutic polysaccharide obtained from aloe vera comprises acemannan.
Claim 39
Dependent Claim
15 words
The therapeutic device as in claim 32, wherein said therapeutic device comprises freeze-dried acemannan hydrogel.
Claim 40
Dependent Claim
16 words
The device as in claim 32, wherein said therapeutic device is adhered to an adhesive backing.
Claim 41
Dependent Claim
11 words
The therapeutic device as in claim 32, further comprising an antibiotic.
Claim 42
Dependent Claim
21 words
The therapeutic device as in claim 38, wherein said antibiotic is selected from the group consisting of tetracycline, oxytetracycline, and gentamycin.
Claim 43
Dependent Claim
12 words
The therapeutic device as in claim 32, further comprising a pharmaceutical agent.
Claim 44
Dependent Claim
14 words
The therapeutic device as in claim 40, wherein said pharmaceutical agent comprises an antihistamine.
Claim 45
Dependent Claim
28 words
The therapeutic device as in claim 40, wherein said pharmaceutical agent is selected from the group consisting of an anticancer agent, an antiviral agent, and an antifungal agent.
Claim 46
Dependent Claim
11 words
The therapeutic device as in claim 32, further comprising a biologic.
Claim 47
Dependent Claim
23 words
The therapeutic device as in claim 43, wherein said biologic is selected from the group consisting of a hormone and a growth factor.
Claim 48
Dependent Claim
12 words
The therapeutic device as in claim 32, further comprising a hemostatic agent.
Claim 49
Dependent Claim
11 words
The therapeutic device as in claim 32, further comprising a microorganism.
Claim 50
Dependent Claim
13 words
The therapeutic device as in claim 46, wherein said microorganism comprises a vaccine.
Claim 51
Dependent Claim
15 words
The therapeutic device as in claim 47, wherein said vaccine comprises a modified live virus.
Claim 52
Dependent Claim
14 words
The therapeutic device as in claim 47, wherein said vaccine comprises a killed virus.
Claim 53
Dependent Claim
13 words
The therapeutic device as in claim 47, wherein said vaccine comprises vital components.
Claim 54
Dependent Claim
11 words
The therapeutic device as in claim 32, further comprising a preservative.
Claim 55
Dependent Claim
21 words
The therapeutic device as in claim 51, wherein said preservative is selected from the group consisting of methylparaben and benzethonium chloride.
Claim 56
Dependent Claim
12 words
The therapeutic device as in claim 32, further comprising a topical anesthetic.
Claim 57
Dependent Claim
11 words
The therapeutic device as in 32, further comprising a metal ion.
Claim 58
Dependent Claim
11 words
The therapeutic device as in 32, further comprising a metal ion.
Claim 59
Dependent Claim
23 words
The therapeutic device as in claim 54, wherein said metal ion is selected from the group consisting of zinc, cobalt, iron, and manganese.
Claim 60
Dependent Claim
15 words
The therapeutic device as in claim 32, wherein said therapeutic device is sterilized by radiation.
Claim 61
Dependent Claim
72 words
A therapeutic device comprising from about 85% to about 95% by weight of acemannan dispersed in from about 5% to about 15% by weight of water, wherein said therapeutic device being in the form of a flexible solid foam that can be to the shape of a wound or lesion, said therapeutic device having gas bubbles dispersed throughout and being capable of being transformed into a hydrogel upon absorption of additional water.
Claim 62
Dependent Claim
72 words
A therapeutic device comprising from about 85% to about 95% by weight of acemannan dispersed in from about 5% to about 15% by weight of water, wherein said therapeutic device being in the form of a flexible solid foam that can be to the shape of a wound or lesion, said therapeutic device having gas bubbles dispersed throughout and being capable of being transformed into a hydrogel upon absorption of additional water.
Claim 63
Dependent Claim
14 words
The therapeutic device of claim 57, wherein said therapeutic device is sterilized by radiation.
Claim 64
Independent Claim
80 words
A method of preparing a therapeutic device comprising: dispersing particles of a hydrophilic-hygroscopic therapeutic polysaccharide obtained from aloe vera in a liquid medium to give a hydrogel; and removing said liquid medium to give said therapeutic device in the form of a flexible solid foam that can be cut to the shape of a wound or lesion, said therapeutic device having gas bubbles dispersed throughout and being capable of being transformed into said hydrogel upon absorption of additional liquid medium.
Claim 65
Independent Claim
80 words
A method of preparing a therapeutic device comprising: dispersing particles of a hydrophilic-hygroscopic therapeutic polysaccharide obtained from aloe vera in a liquid medium to give a hydrogel; and removing said liquid medium to give said therapeutic device in the form of a flexible solid foam that can be cut to the shape of a wound or lesion, said therapeutic device having gas bubbles dispersed throughout and being capable of being transformed into said hydrogel upon absorption of additional liquid medium.
Claim 66
Dependent Claim
11 words
The method of claim 59, further comprising irradiating said therapeutic device.
Claim 67
Independent Claim
75 words
A method of preparing a therapeutic device comprising: dispersing particles of a therapeutic polysaccharide obtained from aloe vera in water to give a hydrogel; and freeze-drying said hydrogel to give said therapeutic device in the form of a flexible solid foam that can be cut to the shape of a wound or lesion, said therapeutic device having gas bubbles dispersed throughout and being capable of being transformed into said hydrogel upon absorption of additional water.
Claim 68
Independent Claim
75 words
A method of preparing a therapeutic device comprising: dispersing particles of a therapeutic polysaccharide obtained from aloe vera in water to give a hydrogel; and freeze-drying said hydrogel to give said therapeutic device in the form of a flexible solid foam that can be cut to the shape of a wound or lesion, said therapeutic device having gas bubbles dispersed throughout and being capable of being transformed into said hydrogel upon absorption of additional water.
Claim 69
Dependent Claim
11 words
The method of claim 61, further comprising irradiating said therapeutic device.
Claim 70
Independent Claim
108 words
A method of treating a wound or lesion in am animal comprising: applying to said wound or lesion an effective amount of a therapeutic device comprising a dried hydrogel in the form of a flexible solid foam that can be cut to the shape of a wound or lesion, said therapeutic device having gas bubbles dispersed throughout, and being prepared by removing a liquid medium from a hydrogel, said hydrogel comprising particles of a hydrophilic-hygroscopic therapeutic polysaccharide dispersed in said liquid medium, wherein said therapeutic polysaccharide is obtained from aloe vera, said therapeutic device being capable of being transformed into said hydrogel upon absorption of additional liquid medium.
Claim 71
Independent Claim
108 words
A method of treating a wound or lesion in am animal comprising: applying to said wound or lesion an effective amount of a therapeutic device comprising a dried hydrogel in the form of a flexible solid foam that can be cut to the shape of a wound or lesion, said therapeutic device having gas bubbles dispersed throughout, and being prepared by removing a liquid medium from a hydrogel, said hydrogel comprising particles of a hydrophilic-hygroscopic therapeutic polysaccharide dispersed in said liquid medium, wherein said therapeutic polysaccharide is obtained from aloe vera, said therapeutic device being capable of being transformed into said hydrogel upon absorption of additional liquid medium.
Claim 72
Independent Claim
72 words
A method of treating a wound or lesion in an animal comprising: applying to said wound or lesion an effective amount of a therapeutic device comprising a freeze-dried acemannan hydrogel in the form of a flexible solid foam that can be cut to the shape of a wound or lesion, said therapeutic device having gas bubbles dispersed throughout and being capable of being transformed into a hydrogel upon absorption of additional water.
Claim 73
Independent Claim
72 words
A method of treating a wound or lesion in an animal comprising: applying to said wound or lesion an effective amount of a therapeutic device comprising a freeze-dried acemannan hydrogel in the form of a flexible solid foam that can be cut to the shape of a wound or lesion, said therapeutic device having gas bubbles dispersed throughout and being capable of being transformed into a hydrogel upon absorption of additional water.
Claim 74
Dependent Claim
18 words
The method of claim 63, wherein said wound or lesion is in the oral cavity of said animal.
Claim 75
Dependent Claim
18 words
The method of claim 64, wherein said wound or lesion is in the oral cavity of said animal.
Claim 76
Dependent Claim
19 words
The method of claim 66, wherein said animal is a human and said wound or lesion is aphthous ulcers.
Claim 77
Dependent Claim
19 words
The method of claim 66, wherein said animal is a human and said wound or lesion is Herpes labialis.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-04-24 | 1998-10-24 | 1999-04-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-04-24 | 2002-10-24 | 2003-04-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-04-24 | 2006-10-24 | 2007-04-25 | $7700.00 | Window Closed / Lapsed |