Patent US5002163A successfully refreshed from Google Patents.
Patent US5427797A successfully refreshed from Google Patents.
US5427797A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Systemic effects of nitric oxide inhalation
Assignee: The Brigham and Women's Hospital Inc
•
Filing: 1993-04-06
•
Granted: 1995-06-27
•
Expires: 2013-04-06
Abstract
Abstract Nitric oxide or nitric oxide releasing or delivering compounds administered by the inhalation route to humans and animals in need thereof have a systemic and pulmonary effect of preventing or treating blood platelet aggregation and coagulation and thus, are useful for the prevention or treatment of systemic platelet aggregation, pulmonary emboli, angina pectoris and acute respiratory distress syndrome.
Inventors
- 👤 Claes G. Frostell
- 👤 Goran Hedenstierna
- 👤 Marieann E. Hogman
- 👤 Joseph Loscalzo
- 👤 Jonathan S. Stamler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 19:45
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/04; A61K38/06; A61K38/063; A61K33/00; A61K38/16; A61K38/17; A61K38/38; A61P; A61P11/00; A61P7/00; A61P7/02; A61P9/00; A61P9/08; A61P9/10
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
69 words
A method for systemically treating a patient to inhibit blood platelet aggregation and coagulation comprising systemically treating a patient for blood platelet aggregation and coagulation by administering by the inhalation route to the lung of a patient in need thereof an amount of a compound effective for systemically inhibiting blood platelet aggregation and coagulation selected from the group consisting of nitric oxide and a compound that delivers nitric oxide.
Claim 2
Independent Claim
69 words
A method for systemically treating a patient to inhibit blood platelet aggregation and coagulation comprising systemically treating a patient for blood platelet aggregation and coagulation by administering by the inhalation route to the lung of a patient in need thereof an amount of a compound effective for systemically inhibiting blood platelet aggregation and coagulation selected from the group consisting of nitric oxide and a compound that delivers nitric oxide.
Claim 3
Dependent Claim
38 words
The method of claim 1 wherein the nitric oxide delivering compound is selected from the group of S-nitrosothiols, S-nitroso-proteins, NONOnates, iron nitrosyls, iron nitrosyls with thiolate ligands, thionitrites, thionitrates, sydnonimines, furoxans, nitrosonium salts, organic nitrates and organic nitrites.
Claim 4
Independent Claim
63 words
A method for treating acute respiratory distress syndrome in a patient in need thereof comprising administering to the lung of a patient suffering from acute respiratory distress syndrome an amount of a pharmaceutical composition which comprises a compound effective for treating acute respiratory distress syndrome in said patient selected from the group consisting of nitric oxide and a compound that delivers nitric oxide.
Claim 5
Independent Claim
63 words
A method for treating acute respiratory distress syndrome in a patient in need thereof comprising administering to the lung of a patient suffering from acute respiratory distress syndrome an amount of a pharmaceutical composition which comprises a compound effective for treating acute respiratory distress syndrome in said patient selected from the group consisting of nitric oxide and a compound that delivers nitric oxide.
Claim 6
Dependent Claim
38 words
The method of claim 3 wherein the nitric oxide delivering compound is selected from the group of S-nitrosothiols; S-nitroso-proteins, NONOnates, iron nitrosyls, iron nitrosyls with thiolate ligands, thionitrites, thionitrates, sydnonimines, furoxans, nitrosonium salts, organic nitrates and organic nitrites.
Claim 7
Independent Claim
76 words
A method for establishing an increased level of nitric oxide in the systemic circulation of a patient in need thereof comprising administering by the inhalation route to the lung of said patient in need thereof an amount of a pharmaceutical composition which comprises a compound effective for establishing an increased level of nitric oxide in the systemic circulation of said patient selected from the group consisting of nitric oxide and a compound that delivers nitric oxide.
Claim 8
Independent Claim
76 words
A method for establishing an increased level of nitric oxide in the systemic circulation of a patient in need thereof comprising administering by the inhalation route to the lung of said patient in need thereof an amount of a pharmaceutical composition which comprises a compound effective for establishing an increased level of nitric oxide in the systemic circulation of said patient selected from the group consisting of nitric oxide and a compound that delivers nitric oxide.
Claim 9
Dependent Claim
38 words
The method of claim 5 wherein the nitric oxide delivering compound is selected from the group of S-nitrosothiols, S-nitroso-proteins, NONOnates, iron nitrosyls, iron nitrosyls with thiolate ligands, thionitrites, thionitrates, sydnonimines, furoxans, nitrosonium salts, organic nitrates and organic nitrites.
References Cited (Backward Citations)
WO1992010228A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-06-26 | 1998-12-26 | 1999-06-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-06-26 | 2002-12-26 | 2003-06-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-06-26 | 2006-12-26 | 2007-06-27 | $7700.00 | Window Closed / Lapsed |