US5433751A — Bone prosthesis material containing calcium carbo…

Claim 1

Independent Claim 45 words

Bioresorbable bone prosthesis material containing calcium carbonate particles dispersed within a polymer matrix, said particles being smaller than 1 mm in size and representing from 40 to 70% of the total weight, and said polymer matrix comprising an amorphous hydroxy acid polymer that is bioresorbable.

Claim 2

Dependent Claim 45 words

Bioresorbable bone prosthesis material containing calcium carbonate particles dispersed within a polymer matrix, said particles being smaller than 1 mm in size and representing from 40 to 70% of the total weight, and said polymer matrix comprising an amorphous hydroxy acid polymer that is bioresorbable.

Claim 3

Dependent Claim 14 words

Material according to the claim 1 wherein said polymer is a lactic acid polymer.

Claim 4

Dependent Claim 79 words

Bioresorbable bone prosthesis material containing calcium carbonate particles dispersed within a polymer matrix, said particles being smaller than 1 mm in size and representing from 40 to 70% of the total weight, and said polymer matrix comprising a bioresorbable and amorphous polymer that is a poly(lactic acid) consisting of a mixture of units derived from D- and L-lactic acids, the proportions of each of the D and L units being sufficient for the said poly(lactic acid) to be amorphous.

Claim 5

Dependent Claim 79 words

Bioresorbable bone prosthesis material containing calcium carbonate particles dispersed within a polymer matrix, said particles being smaller than 1 mm in size and representing from 40 to 70% of the total weight, and said polymer matrix comprising a bioresorbable and amorphous polymer that is a poly(lactic acid) consisting of a mixture of units derived from D- and L-lactic acids, the proportions of each of the D and L units being sufficient for the said poly(lactic acid) to be amorphous.

Claim 6

Dependent Claim 18 words

Material according to the claim 3 wherein said poly(lactic acid) contains from 30 to 70% of D-lactic units.

Claim 7

Dependent Claim 22 words

Material according to the claim 4 wherein said poly(lactic acid) contains equal proportions of the units derived from D- and L-lactic acids.

Claim 8

Dependent Claim 11 words

Material according to claim 1 wherein said polymer is a copolymer.

Claim 9

Dependent Claim 21 words

Material according to claim 6 wherein said copolymer is a copolymer containing units derived from lactic acids and from glycolic acid.

Claim 10

Dependent Claim 24 words

Material according to the claim 7 wherein said copolymer contains up to 50%, expressed in terms of units, of units derived from glycolic acid.

Claim 11

Dependent Claim 35 words

Material according to claim 1 wherein said polymer has a sufficiently high average molecular mass for the material to be capable of withstanding the mechanical stresses to which it has to be subjected after implantation.

Claim 12

Dependent Claim 20 words

Material according to claim 9 wherein said polymer has a weight average molecular mass equal to at least approximately 40,000.

Claim 13

Dependent Claim 32 words

Material according to claim 1 wherein said polymer has a sufficiently low average molecular mass for the material to take the form of a pasty solid at a temperature below 50° C.

Claim 14

Dependent Claim 25 words

Material according to claim 11 wherein said polymer contains at least partially of a polymer having a weight average molecular mass of less than 10,000.

Claim 15

Dependent Claim 18 words

Material according to claim 1 wherein said material contains from 50 to 70% by weight of calcium carbonate.

Claim 16

Dependent Claim 17 words

Material according to claim 1 wherein said calcium carbonate is in the form of calcite or aragonite.

Claim 17

Dependent Claim 23 words

Material according to claim 1 wherein said calcium carbonate is obtained from calcium carbonate-based marine organism skeletons, from mollusk or from bivalve shells.

Claim 18

Dependent Claim 27 words

Material according to claim 15 wherein said calcium carbonate is obtained from coral skeletons, from sea urchin skeletons or spines from sea urchin from Pinctada margaritifera shells.

Claim 19

Dependent Claim 23 words

Material according to claim 1 wherein said material takes the form of a moldable powder or the form of a molded solid item.

Claim 20

Independent Claim 49 words

A method of preparing a bone prosthesis item, comprising forming a bone prosthesis item from a material comprising calcium carbonate particles dispersed within a polymer matrix, said particles being smaller than 1 mm in size, and said polymer being a bioresorbable and amorphous polymer comprising a hydroxy acid polymer.

Claim 21

Independent Claim 49 words

A method of preparing a bone prosthesis item, comprising forming a bone prosthesis item from a material comprising calcium carbonate particles dispersed within a polymer matrix, said particles being smaller than 1 mm in size, and said polymer being a bioresorbable and amorphous polymer comprising a hydroxy acid polymer.

Claim 22

Dependent Claim 21 words

A method according to claim 18, wherein said particles constitute from 40% to 70% of a total weight of said material.

Claim 23

Dependent Claim 32 words

Material according to claim 11, wherein said polymer has a sufficiently low average molecular mass for the material to take the form of a pasty solid at a temperature below 37° C.

Claim 24

Dependent Claim 25 words

Material according to claim 12, wherein said polymer contains at least partially of a polymer having a weight average molecular mass of less than 5,000.

Claim 25

Dependent Claim 46 words

Bioresorbable bone prosthesis material containing particles consisting essentially of calcium carbonate dispersed within a polymer matrix, said particles being smaller than 1 mm in size and representing from 40 to 70% of the total weight and said polymer being a bioresorbable amorphous and hydroy acid polymer.

Claim 26

Dependent Claim 46 words

Bioresorbable bone prosthesis material containing particles consisting essentially of calcium carbonate dispersed within a polymer matrix, said particles being smaller than 1 mm in size and representing from 40 to 70% of the total weight and said polymer being a bioresorbable amorphous and hydroy acid polymer.

Claim 27

Independent Claim 46 words

A method of controlling the rate of degradation of a resorbable and amorphous hydroxy acid polymer comprising adding calcium carbonate particles to said hydroxy acid polymer, said particles having a size of less than 1 mm and representing an amount of 40-70% of the total weight.

Claim 28

Independent Claim 46 words

A method of controlling the rate of degradation of a resorbable and amorphous hydroxy acid polymer comprising adding calcium carbonate particles to said hydroxy acid polymer, said particles having a size of less than 1 mm and representing an amount of 40-70% of the total weight.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1998-07-17	1999-01-16	1999-07-18	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2002-07-17	2003-01-16	2003-07-18	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2006-07-17	2007-01-16	2007-07-18	$7700.00	Window Closed / Lapsed

Bone prosthesis material containing calcium carbonate particles dispersed in a bioresorbable polymer matrix

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