Production of solid pharmaceutical depot forms

Claim 1

A process for the production of solid pharmaceutical depot forms by application of an aqueous dispersion, reconstituted by the addition of water to a pharmaceutically acceptable binder, to a core which contains active substance, wherein the binder is prepared by emulsion polymerization of an ethylenically unsaturated compound selected from the group consisting of C 1-18 alkyl(meth)acrylates, hydroxyalkyl(meth)acrylates, vinyl esters, vinyl lactams, mono- or dicarboxylic acids, monoesters or monoamides of these acids, N-vinylimidazole, N-vinylimidazoline, N-vinylimidazolidine, N-vinylpyridine, monoalkyl- or dialkylaminoalkyl esters or monoalkyl- or dialkylaminoalkylamides of polymerizable carboxylic acids, acrylamidoalkylsulfonic acids, trimethylammonioethyl methacrylate chloride and methylol(meth)acrylamides, which produces a water insoluble polymer, and subsequent spray drying of the resulting aqueous polymer dispersion with 5-50% by weight of a water-soluble pharmaceutically acceptable spraying aid selected from the group consisting of cellulose derivatives, polyvinylpyrrolidones, copolymers of N-vinylpyrrolidone and vinylacetate, starch derivatives and polyvinylalcohols with a glass transition temperature of at least 60° C. and 0-50% by weight, based on the amount of binder, of a pharmaceutically acceptable antiblocking agent, the solid pharmaceutical depot forms exhibiting undiminished release properties of the active substance of the core.