Polymeric coating

Claim 2

A process for coating a surface comprising applying to the surface a solution of a polymer, in an organic solvent and removing the solvent, wherein the polymer is obtained by polymerizing a phospholipid of formula (I): ##STR7## wherein at least one of B 1 and B 2 is a group of the formula (II): --(CO).sub.p --X.sup.1 --C.tbd.C--C.tbd.C--Y.sup.1 (II) wherein p is 0 or 1, X 1 is an aliphatic or cycloaliphatic group, Y 1 is H or a monovalent aliphatic or cycloaliphatic group, the total number of carbon atoms in X 1 and Y 1 in each B 1 and/or B 2 being 8 to 26, and the other of B 1 and B 2 is either (a) the same or a different group of the formula (II) or (b) is an aliphatic or cycloaliphatic group containing at least 8 carbon atoms; m is 2, 3 or 4 and each R independently represents an alkyl group containing 1 to 4 carbon atoms; wherein said polymer contains repeating units of the following formula (III) ##STR8## wherein one of Z 1 and Z 2 is Y 1 as defined above, and one of Z 3 and Z 4 are Y 1 as defined above, and wherein the other one of Z 1 and Z 2 and the other one of Z 3 and Z 4 are the formula --X 1 --(CO) p --G, wherein X 1 and p are as defined above, and G is a corresponding remaining portion of the phospholipid of formula (I).

Claim 3

A process according to claim 1 in which the surface is a blood-contacting surface.

Claim 4

A process according to claim 1 in which the surface is subject to non-specific adsorption of protein.

Claim 5

A process according to claim 1, wherein in the phospholipid of formula (I), B 1 and B 2 are identical or different groups of the formula (II).

Claim 6

A process according to claim 1 wherein in the phospholipid of formula (I), each group B 1 and/or B 2 of formula (II) contains from 20 to 26 carbon atoms excluding any carbonyl carbon atoms.

Claim 7

A process according to claim 1 wherein in the phospholipid of formula (I), the number of carbon atoms in each X 1 is such that the di-yne will undergo both intramolecular and intermolecular polymerisation on exposure to actinic radiation.

Claim 8

A process according to claim 1 wherein in the phospholipid of formula (I) B 1 and B 2 each represent --CO--(CH.sub.2).sub.8 --C.tbd.C--C.tbd.C--Y.sup.1 wherein the groups Y 1 are the same or different.

Claim 9

A process according to claim 1 wherein in the phospholipid of formula (I) m is 2 and each R is methyl.

Claim 10

A process according to claim 1 wherein the phospholipid of formula (I) is: ##STR9##

Claim 11

A process according to claim 1 wherein the phospholipid of formula (I) is: ##STR10##

Claim 12

A process according to claim 1 wherein said solution also contains said phospholipid of said formula (I).

Claim 13

A process according to claim 1 wherein a mixture comprising a polymer obtained from a phospholipid of formula (I) and a diester of phosphatidyl choline is applied to the surface.

Claim 14

A process according to claim 12 wherein the diester of phosphatidyl choline is dipalmitoyl phosphatidyl choline, dimyristoyl phosphatidyl choline or distearoyl phosphatidyl choline.

Claim 15

A process according to claim 1 which comprises treating the surface to increase the hydrophobicity of the surface, prior to coating with the polymer.

Claim 16

A process according to claim 14 wherein said treating the surface is effected by a reactive alkyl silane or plasma polymerized in the presence of an alkane or alkyl silane.

Claim 17

A process according to claim 1 wherein the surface is coated with said solution of said polymer in a lower alkanol or halogenated alkane or a mixture thereof.

Claim 18

A process according to claim 1 wherein said solution comprises from 0.5 to 35 mg/ml of said polymer.

Claim 19

A process according to claim 1 wherein said solution is coated upon said surface by immersion in a coating bath, spraying, or spin coating.

Claim 20

A process according to claim 1 wherein the coating has a thickness of from 3 to 1000 nm.

Claim 21

A process for coating a surface comprising the steps of (a) treating said surface with a reactive alkyl silane or plasma polymerizing said surface in the presence of an alkane or alkylsilane, (b) after step (a) coating said surface with a solution of a polymer in a solvent selected from the group comprising lower alkanols, halogenated alkanes and mixtures thereof containing from 0.5 to 35 mg/ml of said polymer, by immersion in a coating bath, spraying, or spin coating and (c) removing said solvent, wherein said polymer is a phospholipid of formula (I) ##STR11## wherein at least one of B 1 and B 2 is a group of the formula (II): --(CO).sub.p --X.sup.1 --C.tbd.C--C.tbd.C--Y.sup.1 (II) wherein p is 0 or 1, X 1 is an aliphatic or cycloaliphatic group, Y 1 is H or a monovalent aliphatic or cycloaliphatic group, the total number of carbon atoms in X 1 and Y 1 in each B 1 and/or B 2 being 8 to 26, and the other B 1 and B 2 is either (a) the same or a different group of the formula (II) or (b) is an aliphatic or cycloaliphatic group containing at least 8 carbon atoms; m is 2, 3 or 4 and each R independently represents an alkyl group containing 1 to 4 carbon atoms.

Claim 22

A process for coating a surface comprising the steps of (a) treating said surface with a reactive alkyl silane or plasma polymerizing said surface in the presence of an alkane or alkylsilane, (b) after step (a) coating said surface with a solution of a polymer in a solvent selected from the group comprising lower alkanols, halogenated alkanes and mixtures thereof containing from 0.5 to 35 mg/ml of said polymer, by immersion in a coating bath, spraying, or spin coating and (c) removing said solvent, wherein said polymer is a phospholipid of formula (I) ##STR11## wherein at least one of B 1 and B 2 is a group of the formula (II): --(CO).sub.p --X.sup.1 --C.tbd.C--C.tbd.C--Y.sup.1 (II) wherein p is 0 or 1, X 1 is an aliphatic or cycloaliphatic group, Y 1 is H or a monovalent aliphatic or cycloaliphatic group, the total number of carbon atoms in X 1 and Y 1 in each B 1 and/or B 2 being 8 to 26, and the other B 1 and B 2 is either (a) the same or a different group of the formula (II) or (b) is an aliphatic or cycloaliphatic group containing at least 8 carbon atoms; m is 2, 3 or 4 and each R independently represents an alkyl group containing 1 to 4 carbon atoms.

Claim 23

The process according to claim 1 wherein said process forms a coating having a thickness of 10-500 nm by applying said solution.

Claim 24

A process for coating a surface comprising applying to said surface a solution of a polymer, in an organic solvent and then removing the solvent, wherein the polymer is obtained by polymerizing a phospholipid of formula (I): ##STR12## wherein at least one of B 1 and B 2 is a group of the formula (II): --(CO).sub.p --X.sup.1 --C.tbd.C--C.tbd.C--Y.sup.1 (II) wherein p is 0 or 1, X 1 is an aliphatic or cycloaliphatic group, Y 1 is H or a monovalent aliphatic or cycloaliphatic group, the total number of carbon atoms in X 1 and Y 1 in each B 1 and/or B 2 being 8 to 26, and the other of B 1 and B 2 is either (a) the same or a different group of the formula (II) or (b) is an aliphatic or cycloaliphatic group containing at least 8 carbon atoms; m is 2, 3 or 4 and each R independently represents an alkyl group containing 1 to 4 carbon atoms; wherein said polymer contains repeating units of the following formula (III): ##STR13## wherein one of Z 1 and Z 2 is Y 1 , and one of Z 3 and Z 4 are Y 1 , wherein the other one of Z 1 and Z 2 and the other one of Z 3 and Z 4 are the formula --X 1 --(CO) p --G, wherein X 1 and p are as defined above, and G is a corresponding remaining portion of the phospholipid of formula (I), wherein said solution comprises from 0.5 to 35 mg/ml of said polymer, wherein said process forms a coating having a thickness of from 3 to 1000 nm by application of said solution, wherein in said phospholipid of formula (I), B 1 and B 2 each represent --CO--(CH.sub.2).sub.8 --C.tbd.C--C.tbd.C--Y.sup.1 wherein the groups Y 1 are the same or different.

Claim 25

A process for coating a surface comprising applying to said surface a solution of a polymer, in an organic solvent and then removing the solvent, wherein the polymer is obtained by polymerizing a phospholipid of formula (I): ##STR12## wherein at least one of B 1 and B 2 is a group of the formula (II): --(CO).sub.p --X.sup.1 --C.tbd.C--C.tbd.C--Y.sup.1 (II) wherein p is 0 or 1, X 1 is an aliphatic or cycloaliphatic group, Y 1 is H or a monovalent aliphatic or cycloaliphatic group, the total number of carbon atoms in X 1 and Y 1 in each B 1 and/or B 2 being 8 to 26, and the other of B 1 and B 2 is either (a) the same or a different group of the formula (II) or (b) is an aliphatic or cycloaliphatic group containing at least 8 carbon atoms; m is 2, 3 or 4 and each R independently represents an alkyl group containing 1 to 4 carbon atoms; wherein said polymer contains repeating units of the following formula (III): ##STR13## wherein one of Z 1 and Z 2 is Y 1 , and one of Z 3 and Z 4 are Y 1 , wherein the other one of Z 1 and Z 2 and the other one of Z 3 and Z 4 are the formula --X 1 --(CO) p --G, wherein X 1 and p are as defined above, and G is a corresponding remaining portion of the phospholipid of formula (I), wherein said solution comprises from 0.5 to 35 mg/ml of said polymer, wherein said process forms a coating having a thickness of from 3 to 1000 nm by application of said solution, wherein in said phospholipid of formula (I), B 1 and B 2 each represent --CO--(CH.sub.2).sub.8 --C.tbd.C--C.tbd.C--Y.sup.1 wherein the groups Y 1 are the same or different.

Claim 26

The process according to claim 22 wherein said process forms a coating having a thickness of 10 to 500 nm by applying said solution.

Claim 27

A process for coating a surface comprising: pre-treating said surface by plasma polymerization, covering said surface with a coating comprising a polymer in a solution in an organic solvent, wherein said polymer is obtained by polymerizing a phospholipid of formula (I): ##STR14## wherein at least one of B 1 and B 2 is a group of the formula (II): --(CO).sub.p --X.sup.1 --C.tbd.C--C.tbd.C--Y.sup.1 (II) wherein p is 0 or 1, X 1 is an aliphatic or cycloaliphatic group, Y 1 is H or a monovalent aliphatic or cycloaliphatic group, the total number of carbon atoms in X 1 and Y 1 in each B 1 and/or B 2 being 8 to 26, and the other of B 1 and B 2 is either (a) the same or a different group of the formula (II) or (b) is an aliphatic or cycloaliphatic group containing at least 8 carbon atoms; m is 2, 3 or 4 and each R independently represents an alkyl group containing 1 to 4 carbon atoms; wherein said polymer contains repeating units of the following formula (III): ##STR15## wherein one of Z 1 and Z 2 are Y 1 as defined above, and one of Z 3 and Z 4 are Y 1 as defined above, and wherein the other one of Z 1 and Z 2 and the other one of Z 3 and Z 4 are the formula --X 1 --(CO) p --G, wherein X 1 and p are as defined above, and G is a corresponding remaining portion of the phospholipid of formula (I), and then removing said organic solvent.

Claim 28

A process for coating a surface comprising: pre-treating said surface by plasma polymerization, covering said surface with a coating comprising a polymer in a solution in an organic solvent, wherein said polymer is obtained by polymerizing a phospholipid of formula (I): ##STR14## wherein at least one of B 1 and B 2 is a group of the formula (II): --(CO).sub.p --X.sup.1 --C.tbd.C--C.tbd.C--Y.sup.1 (II) wherein p is 0 or 1, X 1 is an aliphatic or cycloaliphatic group, Y 1 is H or a monovalent aliphatic or cycloaliphatic group, the total number of carbon atoms in X 1 and Y 1 in each B 1 and/or B 2 being 8 to 26, and the other of B 1 and B 2 is either (a) the same or a different group of the formula (II) or (b) is an aliphatic or cycloaliphatic group containing at least 8 carbon atoms; m is 2, 3 or 4 and each R independently represents an alkyl group containing 1 to 4 carbon atoms; wherein said polymer contains repeating units of the following formula (III): ##STR15## wherein one of Z 1 and Z 2 are Y 1 as defined above, and one of Z 3 and Z 4 are Y 1 as defined above, and wherein the other one of Z 1 and Z 2 and the other one of Z 3 and Z 4 are the formula --X 1 --(CO) p --G, wherein X 1 and p are as defined above, and G is a corresponding remaining portion of the phospholipid of formula (I), and then removing said organic solvent.