US5506097A
Expired / Lapsed
US
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Method for inhibiting β-protein enzymatic activity
Assignee: Harvard University
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Filing: 1994-01-10
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Granted: 1996-04-09
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Expires: 2014-01-10
Abstract
Abstract A method of inhibiting the function of beta -protein, particularly enzymatic activity, such as esterase (cholinesterase) or proteinase activity, is to contact beta -protein with a compound which inhibits such enzymatic activity. Examples of such inhibitors are para-amidinophenylmethanesulfonyl fluoride and Ebelactone A, which inhibit the esterase activity of amyloid precursor protein to a greater extent than the esterase activity of acetylcholinesterase.
Inventors
- 👤 Huntington Potter
- 👤 Usamah Kayyali
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:50
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/34; C12Q1/37; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4711; C07K14/81; C07K14/8107; C07K14/811; C07K14/8121; C12Q1/44; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/68; G01N33/6893; G01N33/6896; A; A61; A61K; A61K38/00; G01N2333/00; G01N2333/435; G01N2333/46; G01N2333/47; G01N2333/4701; G01N2333/4709; G01N2333/81; G01N2333/8107; G01N2333/811; G01N2333/8121; G01N2333/8125; G01N2500/00; G01N2500/20; G01N2800/00; G01N2800/28; G01N2800/2814; G01N2800/2821
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
45 words
A method of inhibiting enzymatic activity of Alzheimer amyloid β-protein, comprising contacting Alzheimer amyloid β-protein with an amount of a compound effective to inhibit enzymatic activity of Alzheimer amyloid β-protein, wherein the compound is selected from the group consisting of para-amidinophenylmethanesulfonyl fluoride and Ebelactone A.
Claim 2
Independent Claim
45 words
A method of inhibiting enzymatic activity of Alzheimer amyloid β-protein, comprising contacting Alzheimer amyloid β-protein with an amount of a compound effective to inhibit enzymatic activity of Alzheimer amyloid β-protein, wherein the compound is selected from the group consisting of para-amidinophenylmethanesulfonyl fluoride and Ebelactone A.
Claim 3
Dependent Claim
28 words
The method of claim 1, wherein the enzymatic activity of Alzheimer amyloid β-protein is an esterase activity selected from the group consisting of cholinesterase activity and lipase activity.
Claim 4
Dependent Claim
15 words
The method of claim 2, wherein the compound is a compound which inhibits cholinesterase activity.
Claim 5
Dependent Claim
19 words
The method of claim 2 wherein the compound which inhibits esterase activity is a compound which inhibits lipase activity.
References Cited (Backward Citations)
US4303592A
Cited
GB2071661A
Cited
US4358602A
Cited
US5187153A
Cited
US5234814A
Cited
WO1991013904A1
Cited
US5252463A
Cited
WO1992003542A1
Cited
WO1992003474A1
Cited
US5338663A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-04-09 | 1999-10-09 | 2000-04-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-04-09 | 2003-10-09 | 2004-04-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-04-09 | 2007-10-09 | 2008-04-09 | $7700.00 | Window Closed / Lapsed |