Patent US5540928A successfully refreshed from Google Patents.
US5540928A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Extraluminal regulation of the growth and repair of tubular structures in vivo
Assignee: Harvard University
•
Filing: 1994-04-28
•
Granted: 1996-07-30
•
Expires: 2014-04-28
Abstract
Abstract A method of regulating repair in a physiological system following injury to the lumen of a tubular structure in that system, and of testing the effectiveness of regulatory agent, is presented. The method includes administering a modulator of cell or tissue growth to an extraluminal site adjacent the injured tissue.
Inventors
- 👤 Elazer R. Edelman
- 👤 David H. Adams
- 👤 Morris J. Karnovsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 12:13
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
131 words
A method of regulating repair of a wall of luminal tissue following injury at a location on said wall, said luminal tissue being vas deferens or fallopian tube, said method comprising, administering outside said luminal tissue at said location, a biocompatible polymer based compound-releasing system, said biocompatible polymer based compound-releasing system releasing heparin, said administering taking place over a period of at least 24 hours and being characterized by a rate and dosage that is less than 100 mg/day and is selected to be: a) high enough to control proliferation of smooth muscle cells in said wall at said location; and b) low enough to avoid systemic heparin levels equivalent to an anticoagulant heparin level that would have a discernable effect on clotting function as measured by activated prothrombin tame (aPTT).
Claim 2
Independent Claim
131 words
A method of regulating repair of a wall of luminal tissue following injury at a location on said wall, said luminal tissue being vas deferens or fallopian tube, said method comprising, administering outside said luminal tissue at said location, a biocompatible polymer based compound-releasing system, said biocompatible polymer based compound-releasing system releasing heparin, said administering taking place over a period of at least 24 hours and being characterized by a rate and dosage that is less than 100 mg/day and is selected to be: a) high enough to control proliferation of smooth muscle cells in said wall at said location; and b) low enough to avoid systemic heparin levels equivalent to an anticoagulant heparin level that would have a discernable effect on clotting function as measured by activated prothrombin tame (aPTT).
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein said compound is non-anticoagulant heparin.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein said compound is anticoagulant heparin.
Claim 5
Dependent Claim
18 words
The method of claim 1 wherein said biocompatible polymer-based heparin releasing system comprises an aqueous gel or foam.
Claim 6
Dependent Claim
17 words
The method of claim 1 wherein said injury is surgical repair of said lumen at said location.
References Cited (Backward Citations)
US3797485A
Cited
US3993071A
Cited
US4391797A
Cited
US4495174A
Cited
US4808402A
Cited
US4898732A
Cited
US5120322A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-07-30 | 2000-01-29 | 2000-07-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-07-30 | 2004-01-29 | 2004-07-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-07-30 | 2008-01-29 | 2008-07-30 | $7700.00 | Window Closed / Lapsed |