US5597579A
Expired / Lapsed
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Blends of absorbable polyoxaamides
Assignee: Ethicon Inc
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Filing: 1996-03-05
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Granted: 1997-01-28
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Expires: 2016-03-05
Abstract
Abstract The present invention describes an aliphatic polyoxaamide polymer and blends thereof that may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The aliphatic polyoxaamide of the present invention have a first divalent repeating unit of formula I: [X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)-- ]I and a second repeating unit selected from the group of formulas consisting of: [--Y--R.sub.17 --].sub.T, I [--O--R.sub.5 --C(O)--].sub.B, and II ([--O--R.sub.9 --C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided both X and Y are not both --O-- and may be blended with a second polymer that is preferably biocompatable.
Inventors
- 👤 Rao S. Bezwada
- 👤 Dennis D. Jamiolkowski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 19:29
CPC Classifications
C; C08; C08G; C08G69/00; C08G69/44; A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/225; A61L15/26; A61L15/42; A61L15/60; A61L17/00; A61L17/06; A61L17/10; A61L17/105; A61L27/00; A61L27/14; A61L27/18; A61L27/50; A61L27/52; A61L29/00; A61L29/04; A61L29/049; A61L29/06; A61L29/14; A61L29/145; A61L31/00; A61L31/04; A61L31/041; A61L31/06; C08G63/00; C08G63/66; C08G63/664; C08G63/668; C08G63/672; C08G69/40; C08L; C08L67/00; C08L67/02; C08L67/025; C08L77/00; C08L77/12; C09; C09D; C09D167/00; Y; Y10; Y10T; Y10T428/00; Y10T428/13; Y10T428/1352; Y10T428/1355; Y10T428/1362; Y10T428/24; Y10T428/249921; Y10T428/249953; Y10T428/29; Y10T428/2904; Y10T428/2913; Y10T428/2933; Y10T428/294; Y10T428/2942; Y10T428/2947; Y10T428/31504; Y10T428/31551
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
440 words
An aliphatic polyoxaamides comprising a first divalent repeating unit of formula I: [X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--Y--R.sub.17 --].sub.T, II [--O--R.sub.5 --C(O)--].sub.B, III ([--O--R.sub.9 --C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided that X and Y cannot both be --O--; R, R 1 and R 2 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 3 is selected from the group consisting of an alkylene unit and an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer in the range of from 2 to 12; R 17 is an alkylene unit containing from 2 to 8 carbon atoms which may have substituted therein an internal ether oxygen, an internal --N(R 18 )-- or an internal --C(O)--N(R 21 )--; T is an integer in the range of from 1 to 2,000; R 18 and R 21 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 5 and R 9 are selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 4 --, --(CH 2 ) F --O--C(O)-- and --(CH 2 ) K --C(O)--CH 2 --; R 6 and R 7 are independently selected from the group consisting of hydrogen and an alkyl containing from 1 to 8 carbon atoms; R 8 is selected from the group consisting of hydrogen and methyl; F and K are independently selected integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
Claim 2
Dependent Claim
440 words
An aliphatic polyoxaamides comprising a first divalent repeating unit of formula I: [X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--Y--R.sub.17 --].sub.T, II [--O--R.sub.5 --C(O)--].sub.B, III ([--O--R.sub.9 --C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided that X and Y cannot both be --O--; R, R 1 and R 2 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 3 is selected from the group consisting of an alkylene unit and an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer in the range of from 2 to 12; R 17 is an alkylene unit containing from 2 to 8 carbon atoms which may have substituted therein an internal ether oxygen, an internal --N(R 18 )-- or an internal --C(O)--N(R 21 )--; T is an integer in the range of from 1 to 2,000; R 18 and R 21 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 5 and R 9 are selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 4 --, --(CH 2 ) F --O--C(O)-- and --(CH 2 ) K --C(O)--CH 2 --; R 6 and R 7 are independently selected from the group consisting of hydrogen and an alkyl containing from 1 to 8 carbon atoms; R 8 is selected from the group consisting of hydrogen and methyl; F and K are independently selected integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
Claim 3
Dependent Claim
19 words
The aliphatic polyoxaamides of claim 1 wherein the number average molecular weight of formula III is less than 100,000.
Claim 4
Dependent Claim
43 words
The aliphatic polyoxaamides of claim 1 wherein the polymer has the formula: ##STR7## wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 5
Dependent Claim
43 words
The aliphatic polyoxaamides of claim 1 wherein the polymer has the formula: ##STR8## wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 6
Independent Claim
444 words
A device made from an aliphatic polyoxaamides comprising a first divalent repeating unit of formula I: [X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--Y--R.sub.17 --].sub.T, II [--O--R.sub.5 C(O)--].sub.B, III ([--O--R.sub.9 --C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided that X and Y cannot both be --O--; R, R 1 and R 2 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 3 is selected from the group consisting of an alkylene unit and an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer in the range of from 2 to 12; R 17 is an alkylene unit containing from 2 to 8 carbon atoms which may have substituted therein an internal ether oxygen, an internal --N(R 18 )-- or an internal --C(O)--N(R 21 )--; T is an integer in the range of from 1 to 2,000; R 18 and R 21 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 5 and R 9 are selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 4 --, --(CH 2 ) F --O--C(O)-- and --(CH 2 ) K --C(O)--CH 2 --; R 6 and R 7 are independently selected from the group consisting of hydrogen and an alkyl containing from 1 to 8 carbon atoms; R 8 is selected from the group consisting of hydrogen and methyl; F and K are independently selected integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
Claim 7
Independent Claim
444 words
A device made from an aliphatic polyoxaamides comprising a first divalent repeating unit of formula I: [X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--Y--R.sub.17 --].sub.T, II [--O--R.sub.5 C(O)--].sub.B, III ([--O--R.sub.9 --C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided that X and Y cannot both be --O--; R, R 1 and R 2 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 3 is selected from the group consisting of an alkylene unit and an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer in the range of from 2 to 12; R 17 is an alkylene unit containing from 2 to 8 carbon atoms which may have substituted therein an internal ether oxygen, an internal --N(R 18 )-- or an internal --C(O)--N(R 21 )--; T is an integer in the range of from 1 to 2,000; R 18 and R 21 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 5 and R 9 are selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 4 --, --(CH 2 ) F --O--C(O)-- and --(CH 2 ) K --C(O)--CH 2 --; R 6 and R 7 are independently selected from the group consisting of hydrogen and an alkyl containing from 1 to 8 carbon atoms; R 8 is selected from the group consisting of hydrogen and methyl; F and K are independently selected integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
Claim 8
Dependent Claim
13 words
The device of claim 5 wherein the device is an absorbable surgical device.
Claim 9
Dependent Claim
68 words
The absorbable surgical device of claim 6 wherein the absorbable surgical device is selected from the group consisting of burn dressings, hernia patches, medicated dressings, fascial substitutes, gauze, fabrics, sheets, felts, sponges, gauze bandages, arterial graft, bandages for skin surfaces, suture knot clip, pins, clamps, screws, plates, clips, staples, hooks, buttons, snaps, bone substitutes, intrauterine devices, tubes, surgical instruments, vascular implants, vascular supports, vertebral discs, and artificial skin.
Claim 10
Dependent Claim
13 words
The absorbable surgical device of claim 6 wherein the device is a filament.
Claim 11
Dependent Claim
13 words
The filament of claim 8 wherein the filament is attached to a needle.
Claim 12
Independent Claim
483 words
A device coated with an absorbable coating comprising an aliphatic polyoxaamides having a first divalent repeating unit of formula I: [X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--Y--R.sub.17 --].sub.T, II [--O--R.sub.5 --C(O)--].sub.B, III ([--O--R.sub.9 --C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided that X and Y cannot both be --O--; R, R 1 and R 2 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 3 is selected from the group consisting of an alkylene unit and an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer in the range of from 2 to 12; R 17 is an alkylene unit containing from 2 to 8 carbon atoms which may have substituted therein an internal ether oxygen, an internal --N(R 18 )-- or an internal --C(O)--N(R 21 )--; T is an integer in the range of from 1 to 2,000; R 18 and R 21 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 5 and R 9 are selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 4 --, --(CH 2 ) F --O--C(O)-- and --(CH 2 ) K --C(O)--CH 2 --; R 6 and R 7 are independently selected from the group consisting of hydrogen and an alkyl containing from 1 to 8 carbon atoms; R 8 is selected from the group consisting of hydrogen and methyl; F and K are independently selected integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200; wherein the inherent viscosity of the polyoxaamide is in the range of from about 0.05 to about 2.0 deciliters per gram (dl/g) as measured in a 0.1 g/dl solution of hexafluoroisopropanol (HFIP) at 25° C.
Claim 13
Independent Claim
483 words
A device coated with an absorbable coating comprising an aliphatic polyoxaamides having a first divalent repeating unit of formula I: [X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--Y--R.sub.17 --].sub.T, II [--O--R.sub.5 --C(O)--].sub.B, III ([--O--R.sub.9 --C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided that X and Y cannot both be --O--; R, R 1 and R 2 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 3 is selected from the group consisting of an alkylene unit and an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer in the range of from 2 to 12; R 17 is an alkylene unit containing from 2 to 8 carbon atoms which may have substituted therein an internal ether oxygen, an internal --N(R 18 )-- or an internal --C(O)--N(R 21 )--; T is an integer in the range of from 1 to 2,000; R 18 and R 21 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 5 and R 9 are selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 4 --, --(CH 2 ) F --O--C(O)-- and --(CH 2 ) K --C(O)--CH 2 --; R 6 and R 7 are independently selected from the group consisting of hydrogen and an alkyl containing from 1 to 8 carbon atoms; R 8 is selected from the group consisting of hydrogen and methyl; F and K are independently selected integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200; wherein the inherent viscosity of the polyoxaamide is in the range of from about 0.05 to about 2.0 deciliters per gram (dl/g) as measured in a 0.1 g/dl solution of hexafluoroisopropanol (HFIP) at 25° C.
Claim 14
Dependent Claim
11 words
The device of claim 10 wherein the device is a suture.
Claim 15
Dependent Claim
13 words
The device of claim 11 wherein the suture is attached to a needle.
Claim 16
Dependent Claim
449 words
A drug delivery matrix comprising a drug and an aliphatic polyoxaamide having a first divalent repeating unit of formula I: [X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--Y--R.sub.17 --].sub.T, II [--O--R.sub.5 --C(O)--].sub.B, III ([--O--R--C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided that X and Y cannot both be --O--; R, R 1 and R 2 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 3 is selected from the group consisting of an alkylene unit and an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer in the range of from 2 to 12; R 17 is an alkylene unit containing from 2 to 8 carbon atoms which may have substituted therein an internal ether oxygen, an internal --N(R 18 )-- or an internal --C(O)--N(R 21 )--; T is an integer in the range of from 1 to 2,000; R 18 and R 21 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 5 and R 9 are selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 4 --, --(CH 2 ) F --O--C(O)-- and --(CH 2 ) K --C(O)--CH 2 --; R 6 and R 7 are independently selected from the group consisting of hydrogen and an alkyl containing from 1 to 8 carbon atoms; R 8 is selected from the group consisting of hydrogen and methyl; F and K are independently selected integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
Claim 17
Dependent Claim
449 words
A drug delivery matrix comprising a drug and an aliphatic polyoxaamide having a first divalent repeating unit of formula I: [X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]I and a second repeating unit selected from the group of formulas consisting of: [--Y--R.sub.17 --].sub.T, II [--O--R.sub.5 --C(O)--].sub.B, III ([--O--R--C(O)].sub.P --O--).sub.L G XI and combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided that X and Y cannot both be --O--; R, R 1 and R 2 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 3 is selected from the group consisting of an alkylene unit and an oxyalkylene group of the following formula: --[(CH.sub.2).sub.C --O--].sub.D --(CH.sub.2).sub.E -- IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer in the range of from 2 to 12; R 17 is an alkylene unit containing from 2 to 8 carbon atoms which may have substituted therein an internal ether oxygen, an internal --N(R 18 )-- or an internal --C(O)--N(R 21 )--; T is an integer in the range of from 1 to 2,000; R 18 and R 21 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 5 and R 9 are selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 4 --, --(CH 2 ) F --O--C(O)-- and --(CH 2 ) K --C(O)--CH 2 --; R 6 and R 7 are independently selected from the group consisting of hydrogen and an alkyl containing from 1 to 8 carbon atoms; R 8 is selected from the group consisting of hydrogen and methyl; F and K are independently selected integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
Claim 18
Dependent Claim
18 words
The device of claim 5 wherein the number average molecular weight of formula XI is less than 200,000.
Claim 19
Dependent Claim
43 words
The device of claim 5 wherein the aliphatic polyoxaamides have the formula: ##STR9## wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 20
Dependent Claim
41 words
The device of claim 5 wherein the aliphatic polyoxaamides have ##STR10## wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 21
Dependent Claim
34 words
The device coated with an absorbable coating of claim 10 wherein the aliphatic polyoxaamides have the formula: [--O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.17).sub.T --].sub.N wherein N is an integer in the range of from about 1 to about 10,000.
Claim 22
Dependent Claim
48 words
The device coated with an absorbable coating of claim 10 wherein the aliphatic polyoxaamides have the formula: ##STR11## wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 23
Dependent Claim
48 words
The device coated with an absorbable coating of claim 10 wherein the aliphatic polyoxaamides have the formula: ##STR12## wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 24
Dependent Claim
31 words
The drug delivery matrix of claim 13 wherein the aliphatic polyoxaamide has the formula: [--O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.17).sub.T --].sub.N wherein N is an integer in the range of from about 1 to about 10,000.
Claim 25
Dependent Claim
19 words
The drug delivery matrix of claim 13 wherein the number average weight of formula XI is less than 200,000.
Claim 26
Dependent Claim
51 words
The drug delivery matrix of claim 13 wherein the aliphatic polyoxaamide has the formula: [(--C(O)--C(R.sub.1)(R.sub.2)--O--R.sub.3 --O--C(R.sub.1)(R.sub.2)--C(O)--(Y--R.sub.17).sub.T --X).sub.S ([--O--R.sub.9 --C(O)].sub.P --O--).sub.L G].sub.W wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 27
Dependent Claim
43 words
The aliphatic polyoxaamide of claim 1 wherein the polyoxaamide contains as a second repeat unit a lactone derived repeating unit derived from lactone monomers selected from the group consisting of glycolide, d-lactide, 1-lactide, meso-lactide, ε-caprolactone, p-dioxanone, trimethylene carbonate, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and combinations thereof.
Claim 28
Dependent Claim
44 words
The device of claim 5 wherein the aliphatic polyoxaamide contains as a second repeat unit a lactone derived repeating unit derived from lactone monomers selected from the group consisting of glycolide, d-lactide, 1-lactide, meso-lactide, ε-caprolactone, p-dioxanone, trimethylene carbonate, 1,4 -dioxepan-2-one, 1,5-dioxepan-2-one and combinations thereof.
Claim 29
Dependent Claim
51 words
The device coated with an absorbable coating of claim 10 wherein the aliphatic polyoxaamide in the coating contains as a second repeat unit a lactone derived repeating unit derived from lactone monomers selected from the group consisting of glycolide, d-lactide, 1-lactide, meso-lactide, ε-caprolactone, p-dioxanone, trimethylene carbonate, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and combinations thereof.
Claim 30
Dependent Claim
48 words
The drug delivery matrix of claim 13 wherein the aliphatic polyoxaamide in the matrix contains as a second repeat unit a lactone derived repeating unit derived from lactone monomers selected from the group consisting of glycolide, d-lactide, 1-lactide, meso-lactide, ε-caprolactone, p-dioxanone, trimethylene carbonate, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and combinations thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-01-28 | 2000-07-29 | 2001-01-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-01-28 | 2004-07-29 | 2005-01-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-01-28 | 2008-07-29 | 2009-01-28 | $7700.00 | Window Closed / Lapsed |