US5639671A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for optimizing of an optical assay device
Assignee: Inverness Medical Biostar Inc
•
Filing: 1995-03-28
•
Granted: 1997-06-17
•
Expires: 2015-03-28
Abstract
Abstract Method for optimizing an optical assay device for an analyte, including the steps of: providing a substrate having a chosen thickness of an optically active layer thereon; providing an attachment layer of a chosen thickness on the optical coating; providing a receptive layer of a chosen thickness for the analyte, wherein at least one of the thicknesses of the optically active layer, attachment layer and receptive layer is varied to provide a plurality of thicknesses of that layer; contacting analyte with the receptive layer under conditions in which an increase in mass on the receptive layer results; and determining the optical thickness of the layer.
Inventors
- 👤 Gregory R. Bogart
- 👤 Jeffrey B. Etter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 23:19
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/551; G01N33/552; B; B82; B82Y; B82Y15/00; B82Y30/00; G01N21/00; G01N21/75; G01N21/77; G01N21/78; G01N33/54366; G01N33/54373; G01N2021/7769; G01N2021/7779; G01N2021/7793; Y; Y10; Y10S; Y10S435/00; Y10S435/808
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
152 words
A method for optimization of a visual signal of an optical assay device for the detection of an analyte, comprising the steps of: (a) providing a substrate having a length and an anti-reflective film thereon with a plurality of thicknesses varied incrementally along the length of said substrate, providing an attachment layer of a chosen thickness on said anti-reflective film, providing a receptive layer of a chosen thickness for the analyte on said attachment layer, (b) contacting said analyte with said receptive layer under conditions such that a mass change on said receptive layer results, and (c) determining one or more thicknesses of said plurality of thicknesses of said anti-reflective film that in combination with the other layers of said device produces a visual signal comprising a maximized visual contrast in interference color upon said change in mass relative to a background interference color, over a range of concentrations of said analyte.
Claim 2
Independent Claim
152 words
A method for optimization of a visual signal of an optical assay device for the detection of an analyte, comprising the steps of: (a) providing a substrate having a length and an anti-reflective film thereon with a plurality of thicknesses varied incrementally along the length of said substrate, providing an attachment layer of a chosen thickness on said anti-reflective film, providing a receptive layer of a chosen thickness for the analyte on said attachment layer, (b) contacting said analyte with said receptive layer under conditions such that a mass change on said receptive layer results, and (c) determining one or more thicknesses of said plurality of thicknesses of said anti-reflective film that in combination with the other layers of said device produces a visual signal comprising a maximized visual contrast in interference color upon said change in mass relative to a background interference color, over a range of concentrations of said analyte.
Claim 3
Independent Claim
150 words
A method for optimization of a visual signal of an optical assay device for the detection of an analyte, comprising the steps of: (a) providing a substrate having a length and an anti-reflective film thereon, providing an attachment layer on said substrate said attachment layer with a plurality of thicknesses varied incrementally along the length of said substrate, providing a receptive layer of a chosen thickness for the analyte on said attachment layer, (b) contacting said analyte with said receptive layer under conditions such that a mass change on said receptive layer results, and (c) determining one or more thicknesses of said plurality of thicknesses of said attachment layer that in combination with the other layers of said device produces a visual signal comprising a maximized visual contrast in interference color upon said change in mass relative to a background interference color, over a range of concentrations of said analyte.
Claim 4
Independent Claim
150 words
A method for optimization of a visual signal of an optical assay device for the detection of an analyte, comprising the steps of: (a) providing a substrate having a length and an anti-reflective film thereon, providing an attachment layer on said substrate said attachment layer with a plurality of thicknesses varied incrementally along the length of said substrate, providing a receptive layer of a chosen thickness for the analyte on said attachment layer, (b) contacting said analyte with said receptive layer under conditions such that a mass change on said receptive layer results, and (c) determining one or more thicknesses of said plurality of thicknesses of said attachment layer that in combination with the other layers of said device produces a visual signal comprising a maximized visual contrast in interference color upon said change in mass relative to a background interference color, over a range of concentrations of said analyte.
Claim 5
Independent Claim
153 words
A method for optimization of a visual signal of an optical assay device for the detection of an analyte, comprising the steps of: (a) providing a substrate having a length and upon said substrate an anti-reflective film of an optimal thickness, providing an attachment layer on said substrate said attachment layer with a plurality of thicknesses varied incrementally along the length of said substrate, providing a receptive layer of a chosen thickness for the analyte on said attachment layer, (b) contacting said analyte with said receptive layer under conditions such that a mass change on said receptive layer results, and (c) determining one or more thicknesses of said plurality of thicknesses of said attachment layer that in combination with the other layers of said device produces a visual signal comprising a maximized visual contrast in interference color upon said change in mass relative to a background interference color, over a range of concentrations.
Claim 6
Independent Claim
153 words
A method for optimization of a visual signal of an optical assay device for the detection of an analyte, comprising the steps of: (a) providing a substrate having a length and upon said substrate an anti-reflective film of an optimal thickness, providing an attachment layer on said substrate said attachment layer with a plurality of thicknesses varied incrementally along the length of said substrate, providing a receptive layer of a chosen thickness for the analyte on said attachment layer, (b) contacting said analyte with said receptive layer under conditions such that a mass change on said receptive layer results, and (c) determining one or more thicknesses of said plurality of thicknesses of said attachment layer that in combination with the other layers of said device produces a visual signal comprising a maximized visual contrast in interference color upon said change in mass relative to a background interference color, over a range of concentrations.
Claim 7
Dependent Claim
174 words
(Amended) A method for optimization of a visual signal of an optical assay device for the detection of an analyte, comprising the steps of: (a) providing a substrate having a length and upon said substrate a first anti-reflective film of an optimal thickness and further providing a second anti-reflective film on said first anti-reflective film with a plurality of thicknesses varied incrementally along the length of said substrate, providing an attachment layer of a chosen thickness on said second anti-reflective film, providing a receptive layer of a chosen thickness for the analyte on said attachment layer, (b) contacting said analyte with said receptive layer under conditions such that a mass change on said receptive layer results, and (c) determining one or more thicknesses of said plurality of thicknesses of said second anti-reflective film that in combination with the other layers of said device produces a visual signal comprising a maximized visual contrast in interference color upon said change in mass relative to a background interference color, over a range of concentrations of said analyte.
Claim 8
Dependent Claim
174 words
(Amended) A method for optimization of a visual signal of an optical assay device for the detection of an analyte, comprising the steps of: (a) providing a substrate having a length and upon said substrate a first anti-reflective film of an optimal thickness and further providing a second anti-reflective film on said first anti-reflective film with a plurality of thicknesses varied incrementally along the length of said substrate, providing an attachment layer of a chosen thickness on said second anti-reflective film, providing a receptive layer of a chosen thickness for the analyte on said attachment layer, (b) contacting said analyte with said receptive layer under conditions such that a mass change on said receptive layer results, and (c) determining one or more thicknesses of said plurality of thicknesses of said second anti-reflective film that in combination with the other layers of said device produces a visual signal comprising a maximized visual contrast in interference color upon said change in mass relative to a background interference color, over a range of concentrations of said analyte.
Claim 9
Independent Claim
152 words
A method for optimization of a visual signal of an optical assay device for the detection of an analyte, comprising the steps of: (a) providing a substrate having a length and an anti-reflective film thereon with a plurality of thicknesses varied incrementally along the length of said substrate, providing on said anti-reflective film an attachment layer of an optimal thickness, providing a receptive layer of a chosen thickness for the analyte on said attachment layer, (b) contacting said analyte with said receptive layer under conditions such that a mass change on said receptive layer results, and (c) determining one or more thicknesses of said plurality of thicknesses of said anti-reflective film that in combination with the other layers of said device produces a visual signal comprising a maximized visual contrast in interference color upon said change in mass relative to a background interference color, over a range of concentrations of said analyte.
Claim 10
Independent Claim
152 words
A method for optimization of a visual signal of an optical assay device for the detection of an analyte, comprising the steps of: (a) providing a substrate having a length and an anti-reflective film thereon with a plurality of thicknesses varied incrementally along the length of said substrate, providing on said anti-reflective film an attachment layer of an optimal thickness, providing a receptive layer of a chosen thickness for the analyte on said attachment layer, (b) contacting said analyte with said receptive layer under conditions such that a mass change on said receptive layer results, and (c) determining one or more thicknesses of said plurality of thicknesses of said anti-reflective film that in combination with the other layers of said device produces a visual signal comprising a maximized visual contrast in interference color upon said change in mass relative to a background interference color, over a range of concentrations of said analyte.
References Cited (Backward Citations)
US3002861A
Cited
US3530159A
Cited
US3554787A
Cited
US3530013A
Cited
US3630792A
Cited
US3667926A
Cited
DE2245809A1
Cited
US3839307A
Cited
FR2191744A5
Cited
US4054646A
Cited
US3926564A
Cited
US3960488A
Cited
US3979184A
Cited
US4113757A
Cited
US4090849A
Cited
US4208506A
Cited
US4332476A
Cited
US4421896A
Cited
GB2065298A
Cited
JPS56144541A
Cited
US4363634A
Cited
US4357142A
Cited
US4369268A
Cited
US4508832A
Cited
US4524126A
Cited
US4444862A
Cited
US4497899A
Cited
US4497900A
Cited
US4558012A
Cited
US4568737A
Cited
US4507466A
Cited
US4588120A
Cited
US4672024A
Cited
US4647207A
Cited
US4647544A
Cited
US4535007A
Cited
US4587329A
Cited
US4655595A
Cited
US4818611A
Cited
EP0261642A2
Cited
JPS6378052A
Cited
JPS6378051A
Cited
US4820649A
Cited
US4876208A
Cited
US4886761A
Cited
EP0322549A2
Cited
US5030702A
Cited
US4946920A
Cited
US4959303A
Cited
WO1989009937A1
Cited
EP0347138A2
Cited
US5089387A
Cited
US5047325A
Cited
US5075220A
Cited
US5030561A
Cited
WO1990011525A1
Cited
WO1991004491A1
Cited
WO1991006862A1
Cited
US5104692A
Cited
WO1992003730A1
Cited
US5418136A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-06-16 | 2000-12-16 | 2001-06-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-06-16 | 2004-12-16 | 2005-06-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-06-16 | 2008-12-16 | 2009-06-17 | $7700.00 | Window Closed / Lapsed |