US5667808A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition for sustained release of human growth hormone
Assignee: Alkermes Controlled Therapeutics Inc
•
Filing: 1995-06-07
•
Granted: 1997-09-16
•
Expires: 2015-06-07
Abstract
Abstract The method of using the sustained release composition of the present invention comprises providing a therapeutically effective blood level of biologically active, non-aggregated human growth hormone in a subject for a sustained period by administering to the subject a dose of said sustained release composition.
Inventors
- 👤 OluFunmi Lily Johnson
- 👤 Medha M. Ganmukhi
- 👤 Howard Bernstein
- 👤 Henry Auer
- 👤 M. Amin Khan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 03:28
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1611; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/27; A61K9/1629; A61K9/1641; A61K9/1647; A61K9/1682; A61K9/1694; B; B82; B82Y; B82Y5/00; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/839; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2985
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
89 words
A method for forming a metal cation-complexed human growth hormone, comprising the steps of: a) forming a solution containing human growth hormone; b) dispersing a multivalent metal cation component with the human growth hormone solution under pH conditions suitable for complexing the multivalent metal cation with the human growth hormone, thereby forming a metal cation-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and c) drying said suspension to form the metal cation-complexed human growth hormone.
Claim 2
Independent Claim
89 words
A method for forming a metal cation-complexed human growth hormone, comprising the steps of: a) forming a solution containing human growth hormone; b) dispersing a multivalent metal cation component with the human growth hormone solution under pH conditions suitable for complexing the multivalent metal cation with the human growth hormone, thereby forming a metal cation-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and c) drying said suspension to form the metal cation-complexed human growth hormone.
Claim 3
Dependent Claim
22 words
A method of claim 1 wherein the molar ratio of metal cation component to hGH is between about 6:1 to about 10:1.
Claim 4
Dependent Claim
15 words
A method of claim 1 wherein the hGH solution is in a sodium bicarbonate buffer.
Claim 5
Independent Claim
80 words
A method for forming a zinc-complexed human growth hormone, comprising the steps of: a) forming a solution containing human growth hormone; b) dispersing zinc acetate within the human growth hormone solution under pH conditions suitable for complexing zinc with the human growth hormone, thereby forming a zinc-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and c) drying said suspension to form the zinc-complexed human growth hormone.
Claim 6
Independent Claim
80 words
A method for forming a zinc-complexed human growth hormone, comprising the steps of: a) forming a solution containing human growth hormone; b) dispersing zinc acetate within the human growth hormone solution under pH conditions suitable for complexing zinc with the human growth hormone, thereby forming a zinc-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and c) drying said suspension to form the zinc-complexed human growth hormone.
Claim 7
Independent Claim
87 words
A method for forming a metal cation-complexed human growth hormone, comprising the steps of: a) forming a solution containing human growth hormone; b) dispersing a multivalent metal cation component within the human growth hormone solution at a pH in the range of between about 7.0 and about 7.4, thereby forming a metal cation-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and c) drying said suspension to form the metal cation-complexed human growth hormone.
Claim 8
Independent Claim
87 words
A method for forming a metal cation-complexed human growth hormone, comprising the steps of: a) forming a solution containing human growth hormone; b) dispersing a multivalent metal cation component within the human growth hormone solution at a pH in the range of between about 7.0 and about 7.4, thereby forming a metal cation-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and c) drying said suspension to form the metal cation-complexed human growth hormone.
References Cited (Backward Citations)
US4675189A
Cited
US4767628A
Cited
US4767628B1
Cited
US4906474A
Cited
US4891225A
Cited
US4985404B1
Cited
US4985404A
Cited
US4962091A
Cited
US4981696A
Cited
US4853218A
Cited
US4897268A
Cited
US5192741A
Cited
EP0330180A1
Cited
WO1990009166A1
Cited
US5122367A
Cited
WO1990013780A1
Cited
US5019400A
Cited
US5126147A
Cited
WO1991012882A1
Cited
WO1992011844A1
Cited
WO1993002712A1
Cited
US5176907A
Cited
EP0537559A1
Cited
WO1993007861A1
Cited
WO1993017668A1
Cited
WO1993025221A1
Cited
WO1994012158A1
Cited
WO1995029664A1
Cited
WO1996007399A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-09-15 | 2001-03-17 | 2001-09-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-09-15 | 2005-03-17 | 2005-09-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-09-15 | 2009-03-17 | 2009-09-16 | $7700.00 | Window Closed / Lapsed |