Patent US5667808A successfully refreshed from Google Patents.
US5667808A
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Composition for sustained release of human growth hormone
Assignee: Alkermes Controlled Therapeutics Inc
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Filing: 1995-06-07
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Granted: 1997-09-16
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Expires: 2015-06-07
Abstract
Abstract The method of using the sustained release composition of the present invention comprises providing a therapeutically effective blood level of biologically active, non-aggregated human growth hormone in a subject for a sustained period by administering to the subject a dose of said sustained release composition.
Inventors
- 👤 OluFunmi Lily Johnson
- 👤 Medha M. Ganmukhi
- 👤 Howard Bernstein
- 👤 Henry Auer
- 👤 M. Amin Khan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 06:04
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1611; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/27; A61K9/1629; A61K9/1641; A61K9/1647; A61K9/1682; A61K9/1694; B; B82; B82Y; B82Y5/00; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/839; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2985
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
89 words
A method for forming a metal cation-complexed human growth hormone, comprising the steps of: a) forming a solution containing human growth hormone; b) dispersing a multivalent metal cation component with the human growth hormone solution under pH conditions suitable for complexing the multivalent metal cation with the human growth hormone, thereby forming a metal cation-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and c) drying said suspension to form the metal cation-complexed human growth hormone.
Claim 2
Independent Claim
89 words
A method for forming a metal cation-complexed human growth hormone, comprising the steps of: a) forming a solution containing human growth hormone; b) dispersing a multivalent metal cation component with the human growth hormone solution under pH conditions suitable for complexing the multivalent metal cation with the human growth hormone, thereby forming a metal cation-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and c) drying said suspension to form the metal cation-complexed human growth hormone.
Claim 3
Dependent Claim
22 words
A method of claim 1 wherein the molar ratio of metal cation component to hGH is between about 6:1 to about 10:1.
Claim 4
Dependent Claim
15 words
A method of claim 1 wherein the hGH solution is in a sodium bicarbonate buffer.
Claim 5
Independent Claim
80 words
A method for forming a zinc-complexed human growth hormone, comprising the steps of: a) forming a solution containing human growth hormone; b) dispersing zinc acetate within the human growth hormone solution under pH conditions suitable for complexing zinc with the human growth hormone, thereby forming a zinc-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and c) drying said suspension to form the zinc-complexed human growth hormone.
Claim 6
Independent Claim
80 words
A method for forming a zinc-complexed human growth hormone, comprising the steps of: a) forming a solution containing human growth hormone; b) dispersing zinc acetate within the human growth hormone solution under pH conditions suitable for complexing zinc with the human growth hormone, thereby forming a zinc-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and c) drying said suspension to form the zinc-complexed human growth hormone.
Claim 7
Independent Claim
87 words
A method for forming a metal cation-complexed human growth hormone, comprising the steps of: a) forming a solution containing human growth hormone; b) dispersing a multivalent metal cation component within the human growth hormone solution at a pH in the range of between about 7.0 and about 7.4, thereby forming a metal cation-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and c) drying said suspension to form the metal cation-complexed human growth hormone.
Claim 8
Independent Claim
87 words
A method for forming a metal cation-complexed human growth hormone, comprising the steps of: a) forming a solution containing human growth hormone; b) dispersing a multivalent metal cation component within the human growth hormone solution at a pH in the range of between about 7.0 and about 7.4, thereby forming a metal cation-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4:1 to about 100:1; and c) drying said suspension to form the metal cation-complexed human growth hormone.
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