Patent US5676144A successfully refreshed from Google Patents.
US5676144A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for determination of chemical species in body fluid
Assignee: Sudormed Inc
•
Filing: 1995-06-07
•
Granted: 1997-10-14
•
Expires: 2015-06-07
Abstract
Abstract Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed. The patch may comprise a plurality of test zones for screening for a plurality of analytes. Additional positive and negative control zones are also disclosed. The patch may comprise a feature to detect tampering with the patch to produce false negative results, especially when used in screens for drugs of abuse. In addition to being useful as a drug of abuse screen, the patch is useful for diagnostic purposes.
Inventors
- 👤 Donald W. Schoendorfer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 21:05
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14507; A61B5/14517; A61B5/14521; A61B10/00; A61B10/0035; A61B10/0045; A61B10/0064; A61B5/41; A61B5/411; A61B5/414; A61B5/415; A61B5/418; A61B5/42; A61B5/4261; A61B5/4266; B; B01; B01L; B01L3/00; B01L3/50; B01L3/505; A61B10/0051; A61B2010/0009; A61F; A61F13/00; A61F2013/00089; A61F2013/00187; A61F2013/00195; A61F2013/00361; A61F2013/00365; A61F2013/00429; A61F2013/00434; A61F2013/00544; A61F2013/00604; A61F2013/00608; A61F2013/00642; A61F2013/00646; A61F2013/00655; A61F2013/00727; A61F2013/00731; A61F2013/00855; A61F2013/00863; A61F2013/00902; A61F13/15; A61F13/84; A61F13/8405; A61F2013/8408; A61F2013/8411; A61F2013/842; A61F2013/8473; A61F2013/8488; A61F2013/8491; A61F7/00; A61F7/02; A61F7/03; A61F7/032
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
103 words
A dermal concentration patch for determining the presence of a photosensitive analyte in a subject mammal's perspiration, comprising: a concentration layer having a first side and a second side; an attenuation layer disposed over the second side of the concentration layer for attenuating the amount of light reaching the concentration layer; and an adhesive membrane on at least one of the concentration layer or attenuation layer for securing the first side of the concentration layer in fluid communication with the subject's skin, wherein water vapor is permitted to escape through the concentration layer and the attenuation layer and outside of the concentration patch.
Claim 2
Dependent Claim
103 words
A dermal concentration patch for determining the presence of a photosensitive analyte in a subject mammal's perspiration, comprising: a concentration layer having a first side and a second side; an attenuation layer disposed over the second side of the concentration layer for attenuating the amount of light reaching the concentration layer; and an adhesive membrane on at least one of the concentration layer or attenuation layer for securing the first side of the concentration layer in fluid communication with the subject's skin, wherein water vapor is permitted to escape through the concentration layer and the attenuation layer and outside of the concentration patch.
Claim 3
Dependent Claim
14 words
The concentration patch of claim 1, wherein the light attenuation layer comprises black paper.
Claim 4
Dependent Claim
15 words
The concentration patch of claim 1 wherein the attenuation layer comprises a light reflective material.
Claim 5
Dependent Claim
14 words
The concentration patch of claim 3, wherein the attenuation layer comprises a metallic surface.
Claim 6
Dependent Claim
19 words
The concentration patch of claim 4, wherein the attenuation layer comprises aluminum foil perforated with a plurality of holes.
Claim 7
Dependent Claim
20 words
The concentration patch of claim 1 wherein the attenuation layer comprises a material capable of substantially absorbing incoming light energy.
Claim 8
Dependent Claim
14 words
The concentration patch of claim 6, wherein the attenuation layer comprises a dark surface.
Claim 9
Dependent Claim
19 words
The concentration patch of claim 1 wherein said concentration layer additionally comprises a specific binding partner for said analyte.
Claim 10
Dependent Claim
14 words
The concentration patch of claim 8, wherein said specific binding partner is an antibody.
Claim 11
Dependent Claim
94 words
A dermal concentration patch for determining the presence of a photosensitive analyte in a subject mammal's perspiration, comprising: a water permeable support layer having a first side and a second side; and a vapor permeable attenuation layer on the second side of the support layer for attenuating the amount of light reaching the support layer, the attenuation layer having an adhesive thereon for securing the first side of the support layer in fluid communication with the subject's skin, wherein water is permitted to escape through the support layer and outside of the concentration patch.
Claim 12
Dependent Claim
94 words
A dermal concentration patch for determining the presence of a photosensitive analyte in a subject mammal's perspiration, comprising: a water permeable support layer having a first side and a second side; and a vapor permeable attenuation layer on the second side of the support layer for attenuating the amount of light reaching the support layer, the attenuation layer having an adhesive thereon for securing the first side of the support layer in fluid communication with the subject's skin, wherein water is permitted to escape through the support layer and outside of the concentration patch.
Claim 13
Dependent Claim
155 words
A dermal concentration patch for determining the presence of a photosensitive analyte in a subject mammal's perspiration, comprising: a concentration zone for collecting and storing said photosensitive analyte, wherein said concentration zone has a first side and a second side, wherein said first side is capable of being placed in fluid communication with the subject's skin; an adhesive layer having a first side and a second side, wherein said first side is proximate to said second side of said concentration zone, for removably securing the first side of said concentration zone in fluid communication with the subject's skin; and an attenuation layer having a first side and a second side, wherein said first side is proximate to said second side of said adhesive layer, for attenuating the transmission of light into said concentration zone, wherein the concentration zone and the attenuation layer allow passage of aqueous components of sweat to outside of the concentration patch.
Claim 14
Dependent Claim
155 words
A dermal concentration patch for determining the presence of a photosensitive analyte in a subject mammal's perspiration, comprising: a concentration zone for collecting and storing said photosensitive analyte, wherein said concentration zone has a first side and a second side, wherein said first side is capable of being placed in fluid communication with the subject's skin; an adhesive layer having a first side and a second side, wherein said first side is proximate to said second side of said concentration zone, for removably securing the first side of said concentration zone in fluid communication with the subject's skin; and an attenuation layer having a first side and a second side, wherein said first side is proximate to said second side of said adhesive layer, for attenuating the transmission of light into said concentration zone, wherein the concentration zone and the attenuation layer allow passage of aqueous components of sweat to outside of the concentration patch.
Claim 15
Independent Claim
115 words
A method of determining the presence of a photosensitive analyte in perspiration of a subject mammal, comprising the steps of: securing a dermal patch having a concentration zone to the subject's skin, wherein said concentration zone is in fluid communication with the subject's skin; collecting perspiration containing said photosensitive analyte from said subject's skin in said concentration zone; attenuating the amount of photoradiation reaching said concentration zone during said collecting step, thereby protecting said photosensitive analyte from excessive photoradiation exposure; concentrating said photosensitive analyte in said concentration zone by allowing aqueous components of perspiration to pass through and escape from said dermal patch; and determining the presence of said photosensitive analyte in said subject's perspiration.
Claim 16
Independent Claim
115 words
A method of determining the presence of a photosensitive analyte in perspiration of a subject mammal, comprising the steps of: securing a dermal patch having a concentration zone to the subject's skin, wherein said concentration zone is in fluid communication with the subject's skin; collecting perspiration containing said photosensitive analyte from said subject's skin in said concentration zone; attenuating the amount of photoradiation reaching said concentration zone during said collecting step, thereby protecting said photosensitive analyte from excessive photoradiation exposure; concentrating said photosensitive analyte in said concentration zone by allowing aqueous components of perspiration to pass through and escape from said dermal patch; and determining the presence of said photosensitive analyte in said subject's perspiration.
Claim 17
Dependent Claim
25 words
The method of claim 12, wherein said attenuating step is accomplished by placing a substantially nontransmissive layer over the concentration zone of said dermal patch.
Claim 18
Dependent Claim
27 words
The method of claim 12, wherein said dermal patch comprises an adhesive layer, and wherein said securing step comprises adhering said adhesive layer to said subject's skin.
Claim 19
Dependent Claim
23 words
The method of claim 14, wherein said attenuating step comprises placing a reflective material proximate to said adhesive layer of said dermal patch.
Claim 20
Dependent Claim
14 words
The method of claim 13, wherein said substantially nontransmissive layer is a metallic material.
Claim 21
Dependent Claim
27 words
The method of claim 12, wherein said attenuating step comprises placing a material capable of substantially absorbing light proximate to said concentration zone of said dermal patch.
Claim 22
Dependent Claim
27 words
The method of claim 14, wherein said attenuating step comprises placing a material capable of substantially absorbing light proximate to said adhesive layer of said dermal patch.
References Cited (Backward Citations)
US2821733A
Cited
US3552929A
Cited
USRE32026E
Cited
US3976049A
Cited
US4190060A
Cited
US4631174A
Cited
US4287153A
Cited
US4266556A
Cited
US4401122A
Cited
US4341207A
Cited
US4329999A
Cited
US4360015A
Cited
US4444193A
Cited
US4542751A
Cited
EP0099748A1
Cited
GB2157955A
Cited
US4595011A
Cited
US4732153A
Cited
US4667665A
Cited
JPS61135646A
Cited
US4960467A
Cited
US4706676A
Cited
US4909256A
Cited
EP0217403A2
Cited
US4756314A
Cited
US4775361A
Cited
US5094248A
Cited
WO1989004630A1
Cited
US4957108A
Cited
US5076273A
Cited
US5203327A
Cited
US5438984A
Cited
US5441048A
Cited
US5131390A
Cited
US5036861A
Cited
US5140986A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-10-13 | 2001-04-14 | 2001-10-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-10-13 | 2005-04-14 | 2005-10-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-10-13 | 2009-04-14 | 2009-10-14 | $7700.00 | Window Closed / Lapsed |