Patent US5716660A successfully refreshed from Google Patents.
US5716660A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tubular polytetrafluoroethylene implantable prostheses
Assignee: Lifeshield Sciences LLC
•
Filing: 1995-05-31
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Granted: 1998-02-10
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Expires: 2015-05-31
Abstract
Abstract An implantable prosthesis comprising an expanded polytetraethylene member having pores present in its wall structure wherein said pores contain a solid insoluble biocompatible, biodegradable material of natural origin. A process of preparing said prostheses is also disclosed.
Inventors
- 👤 Kevin Weadock
- 👤 David J. Lentz
- 👤 Richard J. Zdrahala
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 04:41
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61L27/40; A61L27/44; A61L27/48
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
132 words
A process of preparing an expanded polytetrafluoroethylene (e-PTFE) tubular prosthesis having a microporous wall structure including nodes, internodal spaces and fibrils interconnecting said nodes wherein said internodal spaces have been impregnated with a solid, insoluble biocompatible material, comprising the steps of: preparing a dispersion or solution of a soluble biocompatible, biodegradable material including extracellular matrix proteins selected from the group consisting of collagen, gelatin, vitronectin, fibronectin, laminin, reconstituted basement membrane matrices and mixtures thereof at an acidic pH; contacting said prosthesis with said dispersion or solution to impregnate said internodal spaces with said soluble biocompatible material; increasing the pH of said dispersion or solution to precipitate out said soluble biocompatible, biodegradable material to render it into an insoluble state, whereby said internodal spaces are substantially filled with said insoluble biocompatible, biodegradable material.
Claim 2
Dependent Claim
132 words
A process of preparing an expanded polytetrafluoroethylene (e-PTFE) tubular prosthesis having a microporous wall structure including nodes, internodal spaces and fibrils interconnecting said nodes wherein said internodal spaces have been impregnated with a solid, insoluble biocompatible material, comprising the steps of: preparing a dispersion or solution of a soluble biocompatible, biodegradable material including extracellular matrix proteins selected from the group consisting of collagen, gelatin, vitronectin, fibronectin, laminin, reconstituted basement membrane matrices and mixtures thereof at an acidic pH; contacting said prosthesis with said dispersion or solution to impregnate said internodal spaces with said soluble biocompatible material; increasing the pH of said dispersion or solution to precipitate out said soluble biocompatible, biodegradable material to render it into an insoluble state, whereby said internodal spaces are substantially filled with said insoluble biocompatible, biodegradable material.
Claim 3
Dependent Claim
26 words
A process of claim 1 whereby said precipitating out is achieved by treatment with a buffered phosphate solution to form said solid insoluble biocompatible, biodegradable material.
Claim 4
Dependent Claim
20 words
A process of claim 2 wherein said solid insoluble biocompatible, biodegradable material is cross-linked by exposure to an aldehyde vapor.
Claim 5
Dependent Claim
20 words
A process of claim 1 whereby said e-PTFE structure is rendered hydrophilic by immersion in a solution of water-soluble polymers.
Claim 6
Dependent Claim
33 words
The process of claim 4 wherein said water-soluble polymer is an oxygen-containing hydrocarbon selected from the group consisting of polyvinylalcohol, polyethylene oxide, polyethylene glycol, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose and hydroxypropyl cellulose.
Claim 7
Dependent Claim
25 words
A process of claim 4 wherein said water-soluble polymer is a nitrogen-containing polymer selected from the group consisting of polyacrylamide, polyvinyl pyrrolidone, polyvinylamine and polyethyleneimine.
Claim 8
Dependent Claim
17 words
A processes of claim 1 further comprising a step of rinsing said prosthesis in a sterilizing solution.
Claim 9
Dependent Claim
17 words
A process of claim 7 wherein said step of rinsing includes treating with an ethylene oxide solution.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-02-09 | 2001-08-11 | 2002-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-02-09 | 2005-08-11 | 2006-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-02-09 | 2009-08-11 | 2010-02-10 | $7700.00 | Window Closed / Lapsed |