Patent US1140528A successfully refreshed from Google Patents.
Patent US5733951A successfully refreshed from Google Patents.
US5733951A
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Poly(propylene fumarate)
Assignee: Rice University
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Filing: 1994-04-28
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Granted: 1998-03-31
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Expires: 2014-04-28
Abstract
Abstract A novel pathway for the synthesis of poly(propylene fumarate) includes first producing bis-hydroxypropyl fumarate and then its transesterification into poly(propylene fumarate). This synthetic pathway permits production of high molecular weight poly(propylene fumarate) and enables the production of a composite material useful in orthopedic procedures.
Inventors
- 👤 Michael J. Yaszemski
- 👤 Richard G. Payne
- 👤 Antonios G. Mikos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 09:46
CPC Classifications
C; C08; C08G; C08G63/00; C08G63/02; C08G63/12; C08G63/52; A; A61; A61L; A61L24/00; A61L24/04; A61L24/046
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
59 words
A method for the synthesis of poly(propylene fumarate) comprising the steps of: reacting a monomer composition consisting essentially of bis(hydroxypropyl) fumarate under conditions sufficient to cause its transesterification; and recovering a compound having the formula: ##STR3## where R.sup. 1 is H-- or HO--Pr--R 2 is--H or --C(O)--CH═CH--C(O)OH Pr is propyl or isopropyl, and n is approximately greater than 2.
Claim 2
Independent Claim
59 words
A method for the synthesis of poly(propylene fumarate) comprising the steps of: reacting a monomer composition consisting essentially of bis(hydroxypropyl) fumarate under conditions sufficient to cause its transesterification; and recovering a compound having the formula: ##STR3## where R.sup. 1 is H-- or HO--Pr--R 2 is--H or --C(O)--CH═CH--C(O)OH Pr is propyl or isopropyl, and n is approximately greater than 2.
Claim 3
Dependent Claim
14 words
The method of claim 1, wherein n is from about 5 to about 15.
Claim 4
Dependent Claim
9 words
The method of claim 1, wherein Pr is isopropyl.
Claim 5
Independent Claim
54 words
A method for the synthesis of high molecular weight poly(propylenefumarate) comprising the steps of: reacting a monomer composition consisting essentially of bis(hydroxypropyl) fumarate under heat and vacuum conditions sufficient to cause its transesterification; and recovering poly(propylenefumarate) having a weight average molecular weight of at least 1500 and a polydispersity index of less than 2.2.
Claim 6
Independent Claim
54 words
A method for the synthesis of high molecular weight poly(propylenefumarate) comprising the steps of: reacting a monomer composition consisting essentially of bis(hydroxypropyl) fumarate under heat and vacuum conditions sufficient to cause its transesterification; and recovering poly(propylenefumarate) having a weight average molecular weight of at least 1500 and a polydispersity index of less than 2.2.
Claim 7
Dependent Claim
13 words
The method of claim 4, wherein said heat is less than 220° C.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-03-30 | 2001-09-29 | 2002-03-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-03-30 | 2005-09-29 | 2006-03-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-03-30 | 2009-09-29 | 2010-03-31 | $7700.00 | Window Closed / Lapsed |