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Glucose and lactate sensors

Assignee: Siemens Healthcare Diagnostics Inc
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Filing: 1996-12-19
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Granted: 1998-06-23
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Expires: 2016-12-19
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Abstract

Abstract A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.

Inventors

  • 👤 Thomas C. Maley
  • 👤 Mark W. Boden
  • 👤 Paul A. D'Orazio
  • 👤 Peter G. Edelman

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-05 02:05
CPC Classifications
G; G01; G01N; G01N27/00; G01N27/26; C; C12; C12Q; C12Q1/00; C12Q1/001; C12Q1/005; C12Q1/006; Y; Y10; Y10S; Y10S435/00; Y10S435/817; Y10T; Y10T29/00; Y10T29/49; Y10T29/49002; Y10T29/49117; Y10T29/49204; Y10T29/53; Y10T29/5313; Y10T29/53261; Y10T29/53265

Claims Analysis

Total Claims: 23
Claim 1
Independent Claim 50 words
A reference electrode, comprising: a substrate layer: a cellulose acetate layer, formed from screen printing a paste which comprises: (a) cellulose acetate; and (b) an aprotic solvent, said paste having a viscosity of from about 40,000 centipose to about 350,000 centipoise; and a membrane disposed over said cellulose acetate layer.
Claim 2
Dependent Claim 50 words
A reference electrode, comprising: a substrate layer: a cellulose acetate layer, formed from screen printing a paste which comprises: (a) cellulose acetate; and (b) an aprotic solvent, said paste having a viscosity of from about 40,000 centipose to about 350,000 centipoise; and a membrane disposed over said cellulose acetate layer.
Claim 3
Dependent Claim 19 words
The reference electrode according to claim 1, further comprising a silver-silver chloride layer disposed beneath said cellulose acetate layer.
Claim 4
Dependent Claim 22 words
The reference electrode according to claim 2, wherein said silver-silver chloride layer is disposed between said substrate and said cellulose acetate layer.
Claim 5
Dependent Claim 29 words
The reference electrode according to claim 1, wherein said paste comprises from about 15 grams to about 35 grams of cellulose acetate for every 100 mL of said solvent.
Claim 6
Dependent Claim 24 words
The reference electrode according to claim 1, wherein said paste comprises about 20 grams of cellulose acetate for every 100 mL of said solvent.
Claim 7
Dependent Claim 17 words
The reference electrode according to claim 1, further comprising a dielectric layer supported by said substrate layer.
Claim 8
Dependent Claim 19 words
The reference electrode according to claim 1, wherein said silver-silver chloride layer is disposed beneath said cellulose acetate layer.
Claim 9
Dependent Claim 17 words
The reference electrode according to claim 7, further comprising a dielectric layer supported by said substrate layer.
Claim 10
Dependent Claim 74 words
A reference electrode, comprising: a substrate layer: a dielectric layer supported by said substrate layer: a silver-silver chloride layer supported by said substrate layer: a membrane supported by said substrate layer: and a cellulose acetate layer supported by said substrate layer, said cellulose acetate layer being formed from a cellulose acetate paste, comprising: (a) cellulose acetate; and (b) a solvent, said paste having a viscosity of from about 40,000 centipoise to about 350,000 centipoise.
Claim 11
Dependent Claim 74 words
A reference electrode, comprising: a substrate layer: a dielectric layer supported by said substrate layer: a silver-silver chloride layer supported by said substrate layer: a membrane supported by said substrate layer: and a cellulose acetate layer supported by said substrate layer, said cellulose acetate layer being formed from a cellulose acetate paste, comprising: (a) cellulose acetate; and (b) a solvent, said paste having a viscosity of from about 40,000 centipoise to about 350,000 centipoise.
Claim 12
Dependent Claim 23 words
The reference electrode according to claim 9, wherein said silver-silver chloride layer is disposed between said substrate layer and said cellulose acetate layer.
Claim 13
Dependent Claim 17 words
The reference electrode according to claim 10, wherein said membrane is disposed over said cellulose acetate layer.
Claim 14
Dependent Claim 17 words
The reference electrode according to claim 9, wherein said membrane is disposed over said cellulose acetate layer.
Claim 15
Dependent Claim 29 words
The reference electrode sensor according to claim 12, wherein said paste comprises from about 15 grams to about 35 grams of cellulose acetate for every 100 mL of solvent.
Claim 16
Dependent Claim 19 words
The reference electrode according to claim 9, wherein said silver-silver chloride layer is disposed beneath said cellulose acetate layer.
Claim 17
Dependent Claim 17 words
The reference electrode according to claim 14, wherein said membrane is disposed over said cellulose acetate layer.
Claim 18
Dependent Claim 86 words
A process for forming a reference electrode the process comprising the steps of: (a) providing a substrate layer, a dielectric layer supported by said substrate layer, a conductive strip supported by said substrate layer, and a silver-silver chloride layer supported by said conductive strip: (b) forming a paste by mixing cellulose acetate with a solvent; (c) forming a cellulose acetate layer by screen printing said paste on said silver-silver chloride layer; and (d) disposing a membrane over said cellulose acetate layer to provide said reference electrode.
Claim 19
Dependent Claim 86 words
A process for forming a reference electrode the process comprising the steps of: (a) providing a substrate layer, a dielectric layer supported by said substrate layer, a conductive strip supported by said substrate layer, and a silver-silver chloride layer supported by said conductive strip: (b) forming a paste by mixing cellulose acetate with a solvent; (c) forming a cellulose acetate layer by screen printing said paste on said silver-silver chloride layer; and (d) disposing a membrane over said cellulose acetate layer to provide said reference electrode.
Claim 20
Dependent Claim 17 words
The process accoridng to claim 16, wherein step (b) includes mixing cellulose acetate with an aprotic solvent.
Claim 21
Dependent Claim 33 words
The process according to claim 16, wherein step (b) includes mixing said cellulose acetate with said solvent to form a paste having a viscosity of from about 40,000 centipoise to about 350,000 centipoise.
Claim 22
Dependent Claim 19 words
The process according to claim 16, wherein said step (a) includes disposing said dielectric layer on said substrate layer.
Claim 23
Dependent Claim 25 words
The process according to claim 16, wherein said step (a) includes disposing said silver-silver chloride layer between said cellulose acetate layer and said substrate layer.

References Cited (Backward Citations)

US3871938A Cited
JPS53144883A Cited
US5509410A Cited
US4508613A Cited
US4891125A Cited
US5131999A Cited
EP0470290A1 Cited
US5326449A Cited
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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 2001-06-22 2001-12-22 2002-06-23 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2005-06-22 2005-12-22 2006-06-23 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2009-06-22 2009-12-22 2010-06-23 $7700.00 Window Closed / Lapsed

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