US5830138A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Intravascular catheter probe for clinical oxygen, pH and CO2 measurement
Assignee: Oxygen Enterprises Ltd
•
Filing: 1996-12-16
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Granted: 1998-11-03
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Expires: 2016-12-16
Abstract
Abstract Methods and apparatus for the measurement of oxygen, pH and CO2 in human and animal tissue is provided, in which the compounds preferably include a chromophore and/or fluorphor capable of absorbing an amount of energy and subsequently releasing the energy as phosphorescent and/or fluorescent light, and wherein the phosphorescence is quenched by molecular oxygen according to the Stern-Volmer relationship, CO2 is measured by fluorphor which alters fluorescence with pH.
Inventors
- 👤 David F. Wilson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:30
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14539; A61B5/14542; A61B5/1455; A61B5/1459
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
103 words
A detection device for tissue oxygen and/or pH (CO 2 ) measurement in animals and humans comprising fiber optics means for transmitting emitted phosphorescent and/or fluorescent light, a probe at one end of the fiber optic means comprising a portion of the fiber optic means enclosed by a gas-permeable film, and a reservoir of a liquid which contains an oxygen quenchable phosphorescence emitting oxygen sensor and/or a fluorescence emitting pH sensor situated between the gas-permeable film and the fiber optic means, and further comprising at the other end of the fiber optic means phosphorescent and/or fluorescent detecting means and excitation light emitting means.
Claim 2
Dependent Claim
103 words
A detection device for tissue oxygen and/or pH (CO 2 ) measurement in animals and humans comprising fiber optics means for transmitting emitted phosphorescent and/or fluorescent light, a probe at one end of the fiber optic means comprising a portion of the fiber optic means enclosed by a gas-permeable film, and a reservoir of a liquid which contains an oxygen quenchable phosphorescence emitting oxygen sensor and/or a fluorescence emitting pH sensor situated between the gas-permeable film and the fiber optic means, and further comprising at the other end of the fiber optic means phosphorescent and/or fluorescent detecting means and excitation light emitting means.
Claim 3
Dependent Claim
15 words
The device of claim 1 wherein said sensor is an oxygen-quenchable phosphorescence emitting oxygen sensor.
Claim 4
Dependent Claim
22 words
The device of claim 2 wherein said oxygen sensor comprises an absorption band at a wavelength of greater than about 400 nm.
Claim 5
Dependent Claim
21 words
The device of claim 1 wherein said sensor comprises an emission band at a wavelength of greater than about 400 nm.
Claim 6
Dependent Claim
22 words
The device of claim 1 having absorption and emission bands located in a range from about 400 nm to about 1000 nm.
Claim 7
Dependent Claim
18 words
The detection device of claim 5 wherein said absorption band ranges from about 400 to about 700 nm.
Claim 8
Dependent Claim
10 words
The device of claim 2 wherein said sensor comprises porphyrin.
Claim 9
Dependent Claim
11 words
The detection device of claim 7 wherein said porphyrin comprises metalloporphyrin.
Claim 10
Dependent Claim
56 words
The detection device of claim 8 comprising an oxygen sensor compound which is capable of phosphorescing and which has the formula: ##STR7## wherein: R 1 is substituted or unsubstituted aryl; R 2 and R 3 are independently hydrogen or are linked together to form substituted or unsubstituted aryl; and M is H 2 or a metal.
Claim 11
Dependent Claim
32 words
The detection device of claim 9 wherein the oxygen sensor compound M is a metal selected from the group consisting of Zn, Al, Sn, Y, La, Lu, Pd, Pt and derivatives thereof.
Claim 12
Dependent Claim
15 words
The detection device of claim 10 wherein said derivatives comprise LuOH, YOH, LaOH or AlOH.
Claim 13
Dependent Claim
25 words
The detection device of claim 9 wherein R 2 and R 3 of the oxygen sensor compound are linked together to form an aryl system.
Claim 14
Dependent Claim
15 words
The detection device of claim 12 wherein said aryl system comprises phenyl, naphthyl or anthryl.
Claim 15
Dependent Claim
12 words
The detection device of claim 13 wherein R 1 comprises substituted phenyl.
Claim 16
Dependent Claim
13 words
The detection device of claim 14 wherein said substituted phenyl comprises Pd-meso-tetra-(4-carboxy-phenyl) porphine.
Claim 17
Dependent Claim
28 words
The detection device of any of claims 1-15 in which said portion of said fiber optic means enclosed by said gas permeable film contains one or more grooves.
Claim 18
Dependent Claim
25 words
The detection device of any of claims 1-15 in which the refractive index of said reservoir liquid is near that of said fiber optic means.
Claim 19
Dependent Claim
25 words
The detection device of claim 16 in which the refractive index of said reservoir liquid is substantially identical to that of the fiber optic means.
Claim 20
Dependent Claim
54 words
The detection device of any of claims 1-15 wherein said portion of said fiber optic means enclosed by said gas permeable film contains at least two or more grooves, and wherein at least a portion of the grooves contain oxygen quenchable phosphorescence emitting oxygen sensor and a portion contains a fluorescence emitting pH sensor.
Claim 21
Dependent Claim
21 words
The detection device of claim 19 wherein the refractive index of said liquid is near that of said fiber optic means.
Claim 22
Dependent Claim
23 words
The detection device of claim 20 wherein the refractive index of said liquid is substantially identical to that of the fiber optic means.
Claim 23
Dependent Claim
69 words
A method for tissue oxygen measurement and/or pH measurement in animals and humans with the device of claim 1, comprising: contacting a subject with said probe; emitting excitation light from said emitting means into said fiber optic means; detecting phosphorescent and/or fluorescent emissions from said oxygen quenching and/or fluorescence emitting pH sensor with said detecting means; and measuring tissue oxygen and/or pH based on results of said detecting step.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-11-02 | 2002-05-04 | 2002-11-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-11-02 | 2006-05-04 | 2006-11-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-11-02 | 2010-05-04 | 2010-11-03 | $7700.00 | Window Closed / Lapsed |