US5866554A
Expired / Lapsed
US
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Compositions for prevention of inflammation and adhesion formation and uses thereof
Assignee: Poly Med Inc
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Filing: 1996-07-19
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Granted: 1999-02-02
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Expires: 2016-07-19
Abstract
Abstract Pharmaceutical compositions comprising hyaluronic acid, non-steroidal inflammatory drugs, and organic salts of divalent metals, and methods of using these compositions for the inhibition of inflammation and adhesion formation are described.
Inventors
- 👤 Shalaby W. Shalaby
- 👤 Julie Ann Miller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 18:13
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61K31/726; A61K31/728; A61K31/185; A61K31/19; A61K31/33; A61K31/395; A61K31/40; A61K33/00; A61K33/06; A61K33/24; A61K33/26; A61K33/30; A61K45/00; A61K45/06; C; C08; C08G; C08G18/00; C08G18/06; C08G18/08; C08G18/14; C08G18/28; C08G18/40; C08G18/63; C08G18/632; C08G2110/00; C08G2110/0008; C08G2110/0041; C08G2110/005; C08G2110/0083
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
32 words
A therapeutic composition for use in inhibiting tissue inflammation and adhesion formation in a mammal, said composition comprising hyaluronic acid, a non-steroidal anti-inflammatory agent, and an organic salt of a divalent metal.
Claim 2
Dependent Claim
32 words
A therapeutic composition for use in inhibiting tissue inflammation and adhesion formation in a mammal, said composition comprising hyaluronic acid, a non-steroidal anti-inflammatory agent, and an organic salt of a divalent metal.
Claim 3
Dependent Claim
19 words
The therapeutic composition of claim 1, wherein the molecular weight of the HA is at least 1.0×10 6 Daltons.
Claim 4
Dependent Claim
20 words
The therapeutic composition of claim 1, wherein the NSAID is selected from the group consisting of tolmetin, ibuprofen and naproxen.
Claim 5
Dependent Claim
19 words
The therapeutic composition of claim 1, wherein the organic salt of a divalent metal is a Ca 2+ salt.
Claim 6
Dependent Claim
12 words
The therapeutic composition of claim 4, wherein said salt is calcium acetate.
Claim 7
Dependent Claim
18 words
The therapeutic composition of claim 1, wherein the viscosity of the said composition is less than 18 dl/g.
Claim 8
Dependent Claim
24 words
A therapeutic composition for use in inhibiting tissue inflammation and adhesion formation in a mammal, said composition comprising hyaluronic acid, naproxen and calcium acetate.
Claim 9
Dependent Claim
24 words
A therapeutic composition for use in inhibiting tissue inflammation and adhesion formation in a mammal, said composition comprising hyaluronic acid, naproxen and calcium acetate.
Claim 10
Independent Claim
50 words
A method of inhibiting tissue inflammation and adhesion formation in a mammal, said method comprising administering to said mammal a therapeutic composition comprising hyaluronic acid, a non-steroidal anti-inflammatory agent, and an organic salt of a divalent metal in a dosage effective to inhibit inflammation and adhesion formation in said tissue.
Claim 11
Independent Claim
50 words
A method of inhibiting tissue inflammation and adhesion formation in a mammal, said method comprising administering to said mammal a therapeutic composition comprising hyaluronic acid, a non-steroidal anti-inflammatory agent, and an organic salt of a divalent metal in a dosage effective to inhibit inflammation and adhesion formation in said tissue.
Claim 12
Dependent Claim
21 words
The method of claim 8, wherein said mammal is at risk of tissue adhesion formation as a result of tissue injury.
Claim 13
Dependent Claim
20 words
The method of claim 8, wherein said mammal is at risk of tissue adhesion formation as a result of surgery.
Claim 14
Dependent Claim
15 words
The method of claim 10, wherein said surgery is at the site of a tendon.
Claim 15
Dependent Claim
10 words
The method of claim 8, wherein said administration is local.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 7.5 Years (Year 8) | 2006-02-01 | 2006-08-03 | 2007-02-02 | $3760.00 | Window Closed / Lapsed |
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