US5981598A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Deprenyl compounds for treatment of glaucoma
Assignee: University of Toronto
•
Filing: 1998-07-20
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Granted: 1999-11-09
•
Expires: 2018-07-20
Abstract
Abstract Methods and kits for treament of glaucoma are disclosed. In general, the methods of the invention include administering a therapeutically effective amount of a deprenyl compound to a subject such that the subject is treated for glaucoma.
Inventors
- 👤 William G. Tatton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:25
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K31/137; A61P; A61P27/00; A61P27/02; A61P27/06
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
29 words
A method for treating a subject for glaucoma, comprising: administering a therapeutically effective amount of a deprenyl compound to a subject such that the subject is treated for glaucoma.
Claim 2
Independent Claim
29 words
A method for treating a subject for glaucoma, comprising: administering a therapeutically effective amount of a deprenyl compound to a subject such that the subject is treated for glaucoma.
Claim 3
Dependent Claim
133 words
The method of claim 1, wherein the deprenyl compound is represented by the structure: ##STR12## in which R 1 is hydrogen, alkyl, alkenyl, alkynyl, aralkyl, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, or aryloxycarbonyl; R 2 is hydrogen or alkyl; R 3 is a single bond, alkylene, or --(CH 2 ) n--X-- (CH 2 ) m ; in which X is O, S, or N-methyl; m is 1 or 2; and n is 0,1, or 2; R 4 is alkyl, alkenyl, alkynyl, heterocyclyl, aryl or aralkyl; and R 5 is alkylene, alkenylene, alkynylene and alkoxylene; and R 6 is C 3 -C 6 cycloalkyl or --C.tbd.CH; or R 2 and R 4 --R 3 are joined to form, together with the methine to which they are attached, a cyclic or polycyclic group; and pharmaceutically acceptable salts thereof.
Claim 4
Dependent Claim
17 words
The method of claim 2, wherein R 1 is a group that can be removed in vivo.
Claim 5
Dependent Claim
10 words
The method of claim 2, wherein R 1 is hydrogen.
Claim 6
Dependent Claim
10 words
The method of claim 2, wherein R 1 is alkyl.
Claim 7
Dependent Claim
10 words
The method of claim 5, wherein R 1 is methyl.
Claim 8
Dependent Claim
10 words
The method of claim 2, wherein R 2 is methyl.
Claim 9
Dependent Claim
10 words
The method of claim 2, wherein R 3 is methylene.
Claim 10
Dependent Claim
10 words
The method of claim 2, wherein R 4 is aryl.
Claim 11
Dependent Claim
10 words
The method of claim 2, wherein R 4 is phenyl.
Claim 12
Dependent Claim
10 words
The method of claim 2, wherein R 5 is methylene.
Claim 13
Dependent Claim
10 words
The method of claim 2, wherein R 6 is --C.tbd.CH.
Claim 14
Dependent Claim
27 words
The method of claim 2, wherein the deprenyl compound has the structure ##STR13## wherein R 1 is hydrogen, alkyl, alkenyl, alkynyl, aralkyl, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, or aryloxycarbonyl.
Claim 15
Dependent Claim
11 words
The method of claim 1, wherein the deprenyl compound is (-)-deprenyl.
Claim 16
Dependent Claim
11 words
The method of claim 1, wherein the deprenyl compound is (-)-pargyline.
Claim 17
Dependent Claim
11 words
The method of claim 1, wherein the deprenyl compound is (-)-desmethyldeprenyl.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-11-08 | 2003-05-10 | 2003-11-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-11-08 | 2007-05-10 | 2007-11-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-11-08 | 2011-05-10 | 2011-11-09 | $7700.00 | Window Closed / Lapsed |