US5997530A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Apparatus and method to control atmospheric water vapor composition and concentration during dynamic cooling of biological tissues in conjunction with laser irradiations
Assignee: University of California
•
Filing: 1998-04-13
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Granted: 1999-12-07
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Expires: 2018-04-13
Abstract
Abstract Cryogen spray cooling of skin surface with millisecond cryogen spurts is an effective method for establishing a controlled temperature distribution in tissue and protecting the epidermis from nonspecific thermal injury during laser mediated dermatological procedures. Control of humidity level, spraying distance and cryogen boiling point is material to the resulting surface temperature. Decreasing the ambient humidity level results in less ice formation on the skin surface without altering the surface temperature during the cryogen spurt. For a particular delivery nozzle, increasing the spraying distance to 85 millimeters lowers the surface temperature. The methodology comprises establishing a controlled humidity level in the theater of operation of the irradiation site of the biological tissues before and/or during the cryogenic spray cooling of the biological tissue. At cold temperatures calibration was achieved by mounting a thermistor on a thermoelectric cooler. The thermal electric cooler was cooled from from 20 DEG C. to about -20 DEG C. while measuring its infrared emission.
Inventors
- 👤 J. Stuart Nelson
- 👤 Bahman Anvari
- 👤 B. Samuel Tanenbaum
- 👤 Thomas E. Milner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 21:36
CPC Classifications
A; A61; A61B; A61B90/00; A61B90/04; A61B18/00; A61B18/02; A61B18/0218; A61B18/18; A61B18/20; A61B18/203; A61B2018/00005; A61B2018/00011; A61B2018/00029; A61B2018/00315; A61B2018/00452; A61B2090/049
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
65 words
A method for cryogen spray cooling of biological tissue in conjunction with photoradiation comprising: providing a laser; establishing a controlled humidity theater at a site of irradiation of said biological tissue; and cryogenically spray cooling said site of biological tissue when the humidity of said theater has been established so that thermal mediation of said biological tissue by laser irradiation is controllable and hence repeatable.
Claim 2
Independent Claim
65 words
A method for cryogen spray cooling of biological tissue in conjunction with photoradiation comprising: providing a laser; establishing a controlled humidity theater at a site of irradiation of said biological tissue; and cryogenically spray cooling said site of biological tissue when the humidity of said theater has been established so that thermal mediation of said biological tissue by laser irradiation is controllable and hence repeatable.
Claim 3
Dependent Claim
32 words
The method of claim 1 where establishing said controlled humidity theater at said site of irradiation of said biological tissue comprises establishing said controlled humidity within an enclosure which includes said theater.
Claim 4
Dependent Claim
25 words
The method of claim 2 where establishing said controlled humidity of said theater within said enclosure further comprises cryogenically spraying said theater within said enclosure.
Claim 5
Dependent Claim
47 words
The method of claim 2 further comprising controlling the temperature of a surface of said site of irradiation according to a distance between a point of injection of said cryogen spray cooling and a point of impingement of said cryogen onto said biological tissue within said theater.
Claim 6
Dependent Claim
36 words
The method of claim 1 wherein establishing said controlled humidity theater at said irradiation site of said biological tissue comprises flowing a gas having a controlled humidity onto said theater without an enclosure of said theater.
Claim 7
Dependent Claim
20 words
The method of claim 5 where flowing said gas having said controlled humidity comprises flooding said theater with said gas.
Claim 8
Dependent Claim
20 words
The method of claim 6 where flooding said theater with said gas comprises flooding said theater with a dry gas.
Claim 9
Dependent Claim
20 words
The method of claim 7 where flooding said theater with dry gas comprises flooding said theater with dry nitrogen gas.
Claim 10
Dependent Claim
47 words
The method of claim 5 further comprising controlling the temperature of a surface of said site of irradiation according to a distance between a point of injection of said cryogen spray cooling and a point of impingement of said cryogen onto said biological tissue within said theater.
Claim 11
Dependent Claim
53 words
The method of claim 1 where establishing said controlled humidity theater at said site of irradiation of said biological tissue comprises establishing said controlled humidity within an enclosure which includes said theater and further comprising measuring humidity within said theater to provide a feedback control signal whereby said controlled humidity theater is established.
Claim 12
Dependent Claim
25 words
The method of claim 10 where establishing said controlled humidity of said theater within said enclosure further comprises cryogenically spraying said theater within said enclosure.
Claim 13
Dependent Claim
36 words
The method of claim 11 wherein establishing humidity control within said enclosure according to said feedback signal comprises separately controlling a water vapor source and a dry gas source, each source being coupled to said enclosure.
Claim 14
Dependent Claim
23 words
The method of claim 1 wherein establishing said controlled humidity of said theater comprises reducing said humidity within said theater from ambient humidity.
Claim 15
Dependent Claim
37 words
The method of claim 13 wherein reducing said humidity within said theater from ambient humidity reduces said humidity to a level sufficient to avoid ice formation on said biological tissue when exposed to said cryogen spray cooling.
Claim 16
Dependent Claim
33 words
The method of claim 14 further comprising controlling the temperature of a surface of said site of irradiation by choice of the boiling point of the cryogen used in said cryogenic spray cooling.
Claim 17
Dependent Claim
47 words
The method of claim 14 further comprising controlling the temperature of a surface of said site of irradiation according to a distance between a point of release of said cryogen spray cooling and a point of impingement of said cryogen onto said biological tissue within said theater.
Claim 18
Dependent Claim
28 words
The method of claim 1 wherein reducing said humidity within said theater from ambient humidity reduces said humidity in said theater to 5% humidity or less by weight.
Claim 19
Independent Claim
40 words
An apparatus for cryogen spray cooling biological tissue comprising: a laser; a source of sprayed cryogen; and means for providing controlled humidity within a theater of laser irradiation of said biological tissue when cryogen is applied thereto from said source.
Claim 20
Independent Claim
40 words
An apparatus for cryogen spray cooling biological tissue comprising: a laser; a source of sprayed cryogen; and means for providing controlled humidity within a theater of laser irradiation of said biological tissue when cryogen is applied thereto from said source.
Claim 21
Dependent Claim
23 words
The apparatus of claim 18 wherein said means comprises a humidity controlled enclosure including at least as an interface thereof at said theater.
Claim 22
Dependent Claim
20 words
The apparatus of claim 18 wherein said means comprises means for flooding said theater with gas having a controlled humidity.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-12-06 | 2003-06-07 | 2003-12-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-12-06 | 2007-06-07 | 2007-12-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-12-06 | 2011-06-07 | 2011-12-07 | $7700.00 | Window Closed / Lapsed |