Patent US6086907A successfully refreshed from Google Patents.
US6086907A
Expired / Lapsed
US
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Method and composition for preventing surgical adhesions
Assignee: University of Florida Research Foundation Inc
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Filing: 1991-08-29
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Granted: 2000-07-11
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Expires: 2011-08-29
Abstract
Abstract An improved method and composition for preventing adhesions during surgery. Tissue surfaces and surgical articles involved in the surgery are coated with a solution of a hydrophilic, polymeric material prior to manipulation of the tissue during surgery. The composition comprises a solution of a polymeric material having a molecular weight of about 500,000 or above having a concentration of from about 0.01 to about 15%, by weight.
Inventors
- 👤 Eugene P. Goldberg
- 👤 Yoseph Yaacobi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:53
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/08; A61L31/10; A61K; A61K31/00; A61K31/70; A61K31/715; A61K31/726; A61K31/727; A61K31/728; A61K31/74; A61K31/785; A61K31/787; A61K31/79; A61L17/00; A61L17/14; A61L17/145; A61L2400/00; A61L2400/18
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
80 words
A composition specifically adapted for coating the surfaces of tissues involved in surgery and the surfaces of articles which contact said tissue surfaces during said surgery to prevent surgical adhesions in said tissue by manipulation thereof during surgery, consisting essentially of a pharmacologically acceptable aqueous solution of from about 0.01% to less than about 1.0% by weight of a hyaluronic acid, a pharmaceutically acceptable salt or complex thereof or mixture thereof, having a molecular weight of about 500,000 or above.
Claim 2
Dependent Claim
80 words
A composition specifically adapted for coating the surfaces of tissues involved in surgery and the surfaces of articles which contact said tissue surfaces during said surgery to prevent surgical adhesions in said tissue by manipulation thereof during surgery, consisting essentially of a pharmacologically acceptable aqueous solution of from about 0.01% to less than about 1.0% by weight of a hyaluronic acid, a pharmaceutically acceptable salt or complex thereof or mixture thereof, having a molecular weight of about 500,000 or above.
Claim 3
Dependent Claim
90 words
A composition specifically adapted for coating the surface of tissues involved in surgery and the surfaces of articles which contact said tissue surfaces during said surgery to prevent surgical adhesions in said tissue by manipulation thereof during surgery, consisting essentially of a pharmacologically acceptable aqueous solution of from about 0.01% to less than about 1.5% by weight of a water-soluble, biocompatible member selected from the group consisting of polyvinylpyrrolidone and polyelectrolyte polysaccharides, excluding hyaluronic acid, pharmaceutically acceptable salts and mixtures thereof, having a molecular weight of about 500,000 or above.
Claim 4
Dependent Claim
90 words
A composition specifically adapted for coating the surface of tissues involved in surgery and the surfaces of articles which contact said tissue surfaces during said surgery to prevent surgical adhesions in said tissue by manipulation thereof during surgery, consisting essentially of a pharmacologically acceptable aqueous solution of from about 0.01% to less than about 1.5% by weight of a water-soluble, biocompatible member selected from the group consisting of polyvinylpyrrolidone and polyelectrolyte polysaccharides, excluding hyaluronic acid, pharmaceutically acceptable salts and mixtures thereof, having a molecular weight of about 500,000 or above.
Claim 5
Dependent Claim
18 words
The composition of claim 2 consisting essentially of a solution of carboxymethylcellulose or a salt or complex thereof.
Claim 6
Dependent Claim
18 words
The composition of claim 2 consisting essentially of a solution of polyvinylpyrrolidone or a salt or complex thereof.
Claim 7
Dependent Claim
102 words
A surgical article, surfaces of which are adapted for contacting tissue surfaces during surgery having a coating thereon formed from a composition specifically adapted for coating th e surfaces of tissues involved in surgery and the surfaces of articles which contact said tissue surfaces during said surgery to prevent surgical adhesions in said tissue by manipulation thereof during surgery, consisting essentially of a pharmacologically acceptable aqueous solution of from about 0.01% to less than about 1.0% by weight of a hyaluronic acid, a pharmaceutically acceptable salt or complex thereof or mixture t hereof, having a molecular weight of about 500,000 or above.
Claim 8
Dependent Claim
102 words
A surgical article, surfaces of which are adapted for contacting tissue surfaces during surgery having a coating thereon formed from a composition specifically adapted for coating th e surfaces of tissues involved in surgery and the surfaces of articles which contact said tissue surfaces during said surgery to prevent surgical adhesions in said tissue by manipulation thereof during surgery, consisting essentially of a pharmacologically acceptable aqueous solution of from about 0.01% to less than about 1.0% by weight of a hyaluronic acid, a pharmaceutically acceptable salt or complex thereof or mixture t hereof, having a molecular weight of about 500,000 or above.
Claim 9
Dependent Claim
112 words
A surgical article, surfaces of which are adapted for contacting tissue surfaces during surgery having a coating thereon formed from a composition specifically adapted for coating the surface of tissues involved in surgery and the surfaces of articles which contact said tissue surfaces during said surgery to prevent surgical adhesions in said tissue by manipulation thereof during surgery, consisting essentially of a pharmacologically acceptable aqueous solution of from about 0.01% to less than about 1.5% by weight of a water-soluble, biocompatible member selected from the group consisting of polyvinylpyrrolidone and polyelectrolyte polysaccharides, excluding hyaluronic acid, pharmaceutically acceptable salts, complexes thereof and mixtures thereof, having a molecular weight of about 500,000 or above.
Claim 10
Dependent Claim
112 words
A surgical article, surfaces of which are adapted for contacting tissue surfaces during surgery having a coating thereon formed from a composition specifically adapted for coating the surface of tissues involved in surgery and the surfaces of articles which contact said tissue surfaces during said surgery to prevent surgical adhesions in said tissue by manipulation thereof during surgery, consisting essentially of a pharmacologically acceptable aqueous solution of from about 0.01% to less than about 1.5% by weight of a water-soluble, biocompatible member selected from the group consisting of polyvinylpyrrolidone and polyelectrolyte polysaccharides, excluding hyaluronic acid, pharmaceutically acceptable salts, complexes thereof and mixtures thereof, having a molecular weight of about 500,000 or above.
Claim 11
Dependent Claim
17 words
The surgical article of claim 6 wherein said member is carboxymethylcellulose or a salt or complex thereof.
Claim 12
Dependent Claim
16 words
The surgical article of claim 6 wherein said member is polyvinylpyrrolidone, a salt or complex thereof.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-07-11 | 2004-01-10 | 2004-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-07-11 | 2008-01-10 | 2008-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-07-11 | 2012-01-10 | 2012-07-11 | $7700.00 | Window Closed / Lapsed |