US6091975A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Minimally invasive detecting device
Assignee: Alza Corp
•
Filing: 1998-04-01
•
Granted: 2000-07-18
•
Expires: 2018-04-01
Abstract
Abstract An agent detecting device comprising a plate (6) having a plurality of microprotrusions (4) for piercing the skin of a patient. Each of the microprotrusions (4) having an electrode (14, 16 and 18) thereon for detecting the presence of an agent in the patient's interstitial fluid.
Inventors
- 👤 Peter E. Daddona
- 👤 Gregory T. Fieldson
- 👤 Avtar S. Nat
- 👤 Wei-Qi Lin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 05:10
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1468; A61B5/1486; A61B5/14865; A61B10/00; A61B10/0045; A61B2010/008
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
50 words
A detecting device, comprising: a plate having at least one microprotrusion fixedly attached to the plate and extending therefrom; and an agent-detecting sensor on the microprotrusion, the microprotrusion having a length which locates the sensor below the outermost layer of a body surface and in contact with a body fluid.
Claim 2
Dependent Claim
50 words
A detecting device, comprising: a plate having at least one microprotrusion fixedly attached to the plate and extending therefrom; and an agent-detecting sensor on the microprotrusion, the microprotrusion having a length which locates the sensor below the outermost layer of a body surface and in contact with a body fluid.
Claim 3
Dependent Claim
36 words
The detecting device of claim 1 further comprising: a detector and wherein the sensor is an electrochemical sensor having a proximal segment attached to the detector and a distal segment having at least one electrode thereon.
Claim 4
Dependent Claim
30 words
The detecting device of claim 1 wherein the microprotrusion locates the sensor just below the outermost layer of the epidermis above the nerve endings and blood vessels of a patient.
Claim 5
Dependent Claim
14 words
The detecting device of claim 1 wherein the sensor is a thin film sensor.
Claim 6
Dependent Claim
14 words
The device of claim 4, wherein the sensor comprises a coating on the microprotrusion.
Claim 7
Dependent Claim
13 words
The detecting device of claim 1 wherein the sensor is a glucose sensor.
Claim 8
Dependent Claim
17 words
The detecting device of claim 1 wherein the sensor is located on two sides of the microprotrusion.
Claim 9
Dependent Claim
20 words
The detecting device of claim 1 wherein the device further comprises means for anchoring the device in the body surface.
Claim 10
Dependent Claim
19 words
The detecting device of claim 1 wherein the plate has an opening therethrough in communication with a fluid-attracting member.
Claim 11
Dependent Claim
15 words
The detecting device of claim 9 wherein the fluid-attracting member is an osmotic salt layer.
Claim 12
Dependent Claim
15 words
The device of claim 1, wherein the microprotrusion is an integral part of the plate.
Claim 13
Dependent Claim
12 words
The device of claim 11, wherein the body fluid is interstitial fluid.
Claim 14
Independent Claim
67 words
A device for detecting an agent below an outermost layer of epidermis of a patient, comprising: at least one electrochemical sensor; and a plurality of skin-piercing microprotrusions fixedly attached to the device, each of the microprotrusions having an electrode of the electrochemical sensor thereon, the microprotrusions having a length, which locates the electrodes below the outermost layer of the epidermis and in contact with a body fluid.
Claim 15
Independent Claim
67 words
A device for detecting an agent below an outermost layer of epidermis of a patient, comprising: at least one electrochemical sensor; and a plurality of skin-piercing microprotrusions fixedly attached to the device, each of the microprotrusions having an electrode of the electrochemical sensor thereon, the microprotrusions having a length, which locates the electrodes below the outermost layer of the epidermis and in contact with a body fluid.
Claim 16
Dependent Claim
30 words
The device of claim 13 wherein the skin-piercing microprotrusions locate the sensor just below the outermost layer of the epidermis above the nerve endings and blood vessels of the patient.
Claim 17
Dependent Claim
31 words
The device of claim 13 wherein one of the microprotrusions is a sample electrode, one of the microprotrusions is a common electrode, and one of the microprotrusions is a reference electrode.
Claim 18
Dependent Claim
20 words
The device of claim 13, further comprising electrical traces extending from each of the electrodes to interface with a detector.
Claim 19
Dependent Claim
17 words
The device of claim 13 wherein each microprotrusion has an enlarged electrode surface at its distal end.
Claim 20
Dependent Claim
17 words
The device of claim 13 wherein each microprotrusion has a diamond-shaped electrode surface at its distal end.
Claim 21
Dependent Claim
18 words
The device of claim 13 wherein the device has an opening therethrough in communication with a fluid-attracting member.
Claim 22
Dependent Claim
14 words
The device of claim 19 wherein the fluid-attracting member is an osmotic salt layer.
Claim 23
Dependent Claim
21 words
The device of claim 13 wherein the electrode of each of the microprotrusions is located on two sides of the microprotrusion.
Claim 24
Dependent Claim
13 words
The device of claim 13 wherein the electrochemical sensor is a glucose sensor.
Claim 25
Independent Claim
81 words
A method for detecting an agent in a patient, comprising: placing a plate against the patient's skin, the plate having at least one microprotrusion fixedly attached to the plate and extending therefrom to pierce the skin when the plate is placed thereon, the microprotrusion having a sensor thereon to detect the agent, the microprotrusion having a length which locates the sensor below an outermost layer of epidermis of the patient and in contact with a body fluid; and detecting the agent.
Claim 26
Independent Claim
81 words
A method for detecting an agent in a patient, comprising: placing a plate against the patient's skin, the plate having at least one microprotrusion fixedly attached to the plate and extending therefrom to pierce the skin when the plate is placed thereon, the microprotrusion having a sensor thereon to detect the agent, the microprotrusion having a length which locates the sensor below an outermost layer of epidermis of the patient and in contact with a body fluid; and detecting the agent.
Claim 27
Dependent Claim
28 words
The method of claim 23 further comprising: locating the sensor just below the outermost layer of the epidermis above the nerve endings and blood vessels of the patient.
Claim 28
Dependent Claim
26 words
The method of claim 23 further comprising: withdrawing fluid from the patient's skin with the detecting device to produce a flow of fluid past the sensor.
Claim 29
Dependent Claim
12 words
The method of claim 23 wherein the detecting step is performed periodically.
Claim 30
Dependent Claim
15 words
The method of claim 23, wherein the microprotrusion is an integral part of the device.
Claim 31
Dependent Claim
12 words
The method of claim 27, wherein the body fluid is interstitial fluid.
Claim 32
Dependent Claim
14 words
The method of claim 23, wherein the sensor comprises a coating on the microprotrusion.
References Cited (Backward Citations)
US3505993A
Cited
US3675766A
Cited
US3964482A
Cited
US3814097A
Cited
DE2506175A1
Cited
US4120292A
Cited
US4195641A
Cited
US4294258A
Cited
US4344440A
Cited
US4539994A
Cited
US4836907A
Cited
US4830014A
Cited
US4685465A
Cited
US4685466A
Cited
US4759374A
Cited
US4844098A
Cited
US4756314A
Cited
DE3713846A1
Cited
US4711247A
Cited
US4703756A
Cited
US4926867A
Cited
US4969468A
Cited
US5029583A
Cited
WO1989002720A1
Cited
US4825879A
Cited
EP0353328A1
Cited
US5445147A
Cited
US5203327A
Cited
US4953552A
Cited
US5140985A
Cited
US5036861A
Cited
US5108819A
Cited
US5285783A
Cited
US5345935A
Cited
US5197471A
Cited
US5279544A
Cited
US5208154A
Cited
US5313940A
Cited
US5267563A
Cited
US5402777A
Cited
US5220919A
Cited
US5425868A
Cited
US5482034A
Cited
US5452717A
Cited
US5497769A
Cited
US5391250A
Cited
US5390671A
Cited
US5535744A
Cited
WO1996037155A1
Cited
WO1996037256A1
Cited
US5600134A
Cited
WO1997007734A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-07-18 | 2004-01-17 | 2004-07-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-07-18 | 2008-01-17 | 2008-07-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-07-18 | 2012-01-17 | 2012-07-18 | $7700.00 | Window Closed / Lapsed |