Transdermal drug applicator

Claim 2

A conformable, pliable and relatively thin transdermal drug applicator for electrophoresis or electroosmosis of at least one medicament through the skin and into the blood stream of a patient comprising: (a) a plurality of juxtaposed flexible drug reservoir units formed with at least one medicament therein; (b) a conformable power source coupled to said plurality of juxtaposed flexible drug reservoir units, said power source having a battery and an electrical circuit formed to provide an electrical potential to said juxtaposed drug reservoir units; (c) a flexible, insulative and hydrophobic material surrounding said plurality of flexible drug reservoir units and said power source while leaving common sides of said plurality of flexible drug reservoir units adapted for contacting the skin, said flexible, insulative and hydrophobic material precluding shorting of said plurality of flexible reservoir units while aiding in providing flexibility to the applicator; and (d) a flexible cover surrounding said plurality of flexible reservoir units, said power source, and said flexible insulative and hydrophobic material while leaving common sides of said plurality of flexible reservoir units adapted for contacting the skin, said flexible cover being provided with a peripheral lip formed to releaseably cooperate with the patient's tissue such that said flexible cover is capable of compensating for movement of the skin during transdermal drug delivery, said flexible cover in combination with said plurality of flexible reservoir units, and said flexible insulative and hydrophobic material allowing said transdermal drug applicator to conform to the surface of a patient's tissue, the conformability of the transdermal drug applicator increasing with the number of said plurality of juxtaposed flexible reservoir units and amount of said insulative and hydrophobic material provided within the transdermal drug applicator.

Claim 3

The transdermal drug applicator of claim 1, wherein at least one of said at least two drug reservoir units including a plurality of drug reservoir units.

Claim 4

The transdermal drug applicator according to claim 2, wherein at least said one of said at least two drug reservoir units is positioned on one electrical pole side of said battery means and another of said at least two drug reservoir units is positioned on the other electrical pole side of said battery means.

Claim 5

The transdermal drug applicator according to claim 2, wherein said plurality of drug reservoir units form an overall grid pattern forming at least one applicator section, (whereby said applicator may be conformable to the contours of the body).

Claim 6

The transdermal drug applicator according claim 4, wherein said at least one applicator section is configured as a rectangle.

Claim 7

The transdermal drug applicator according to claim 5, wherein said rectangle is a square.

Claim 8

The transdermal drug applicator according to claim 4, wherein said at least one applicator section is a plurality of applicator sections.

Claim 9

The transdermal drug applicator according to claim 7, wherein said plurality of applicator sections is a pair of applicator sections forming a unitary applicator.

Claim 10

The transdermal drug applicator according to claim 8, wherein said pair of applicator sections are configured as a pair of rectangles.

Claim 11

The transdermal drug applicator according to claim 8, wherein said plurality of applicator sections are configured as a pair of separate semi-ovals forming a single unitary applicator.

Claim 12

The transdermal drug applicator according to claim 4, wherein said plurality of applicator sections are configured as a plurality of petals emanating from a central area.

Claim 13

A conformable, pliable, and relatively thin transdermal drug applicator for electrophoresis or electroosmosis of at least one medicament through the skin and into the blood stream of a patient comprising: (a) a plurality of juxtaposed flexible drug reservoir units forming a conformable network, at least one of said plurality of juxtaposed flexible drug reservoir units being configured with: (i) at least one medicament; (ii) a flexible circuit board having an electrical circuit and a battery, said flexible circuit board configured for electrically connecting said battery to said at least one medicament; and (iii) a flexible, insulative and hydrophobic material surrounding said at least one medicament and said flexible circuit board while leaving a side of said medicament and said flexible drug reservoir units adapted for contacting the skin, said flexible, insulative and hydrophobic material precluding shorting of said plurality of flexible reservoir units while aiding in providing flexibility to the applicator; and (b) a flexible cover substantially enclosing the applicator including said plurality of juxtaposed flexible reservoir units, said flexible circuit board, and said flexible insulative and hydrophobic material while leaving common sides of said plurality of juxtaposed flexible drug reservoir units adapted for contacting the skin, said flexible cover being provided with a peripheral lip formed to releaseably cooperate with the patient's tissue while allowing the applicator to be mounted and retained on the skin, said flexible cover in combination with said plurality of flexible reservoir units and said insulative and hydrophobic material allowing said applicator to easily compensate for movement of the skin, the conformability of the transdermal drug applicator increasing with the number of said plurality of juxtaposed flexible reservoir units and amount of said insulative and hydrophobic material provided within the transdermal drug applicator, while said applicator deforming and flexing to thereby conform to the contours of the patient's tissue and complete an electrical circuit through the skin via said flexible circuit board.

Claim 14

A conformable, pliable, and relatively thin transdermal drug applicator for electrophoresis or electroosmosis of at least one medicament through the skin and into the blood stream of a patient comprising: (a) a plurality of juxtaposed flexible drug reservoir units forming a conformable network, at least one of said plurality of juxtaposed flexible drug reservoir units being configured with: (i) at least one medicament; (ii) a flexible circuit board having an electrical circuit and a battery, said flexible circuit board configured for electrically connecting said battery to said at least one medicament; and (iii) a flexible, insulative and hydrophobic material surrounding said at least one medicament and said flexible circuit board while leaving a side of said medicament and said flexible drug reservoir units adapted for contacting the skin, said flexible, insulative and hydrophobic material precluding shorting of said plurality of flexible reservoir units while aiding in providing flexibility to the applicator; and (b) a flexible cover substantially enclosing the applicator including said plurality of juxtaposed flexible reservoir units, said flexible circuit board, and said flexible insulative and hydrophobic material while leaving common sides of said plurality of juxtaposed flexible drug reservoir units adapted for contacting the skin, said flexible cover being provided with a peripheral lip formed to releaseably cooperate with the patient's tissue while allowing the applicator to be mounted and retained on the skin, said flexible cover in combination with said plurality of flexible reservoir units and said insulative and hydrophobic material allowing said applicator to easily compensate for movement of the skin, the conformability of the transdermal drug applicator increasing with the number of said plurality of juxtaposed flexible reservoir units and amount of said insulative and hydrophobic material provided within the transdermal drug applicator, while said applicator deforming and flexing to thereby conform to the contours of the patient's tissue and complete an electrical circuit through the skin via said flexible circuit board.

Claim 15

The transdermal drug applicator according to claim 12, wherein said reservoir units all have substantially the same structure.

Claim 16

The transdermal drug applicator according to claim 12, wherein one of said at least two reservoir units is positioned on one electrical pole side of said battery means and at least one of the other reservoir units is positioned on the other electrical post side of said battery means.

Claim 17

The transdermal drug applicator required to claim 12, wherein said lift means extends outwardly opposite applicator.

Claim 18

The transdermal drug applicator according to claim 15, said lip means extending in a plane generally paralleling a plane passing through the sides of said reservoir units exposed for contacting the skin of said patient.

Claim 19

The transdermal drug applicator according to claim 15, said lip means forming an uninterrupted peripheral zone circumscribing said applicator boundary.

Claim 20

The transdermal drug applicator according to claim 17, wherein said lip means is integrally formed with said means for covering and extends outwardly thereof forming a lateral annular flange about said applicator.

Claim 21

The transdermal drug applicator according to claim 12, wherein the shape of said reservoir units is selected from the group comprising rectangular, squarish, oval, half-oval and triangular shape.

Claim 22

A conformable, pliable, and relatively thin transdermal drug applicator for electrophoresis or electroosmosis of at least one medicament through the skin and into the blood stream of a patient comprising: (a) a plurality of juxtaposed flexible drug reservoir units forming a cell-like network, said plurality of juxtaposed flexible drug reservoir units having at least one medicament in at least one of said plurality of juxtaposed flexible drug reservoir units; (b) a power source coupled to said plurality of juxtaposed flexible drug reservoir units, said power source having a circuit including a battery, said circuit configured to electrically connect said battery to said at least one medicament in at least one of said plurality of juxtaposed flexible drug reservoir units; (c) a flexible, insulative and hydrophobic material surrounding said plurality of flexible drug reservoir units and said power source while leaving common sides of said plurality of flexible drug reservoir units being adapted for contacting the skin, said flexible, insulative and hydrophobic material precluding shorting of said plurality of flexible reservoir units while aiding in providing flexibility to the applicator; and (d) a flexible cover substantially surrounding said plurality of juxtaposed flexible drug reservoir units, said power source, and said flexible insulative and hydrophobic material while leaving common sides of said plurality of juxtaposed flexible drug reservoir units adapted for contacting the skin, said flexible cover being provided with a peripheral lip formed to releaseably cooperate with the patient's tissue while allowing the transdermal drug applicator to be mounted and retained on the skin, said flexible cover in combination with said plurality of flexible reservoir units and said insulative and hydrophobic material allowing said applicator to easily compensate for movement of the skin, the conformability of the transdermal drug applicator increasing with the number of said plurality of juxtaposed flexible reservoir units and amount of said insulative and hydrophobic material provided within the transdermal drug applicator, while said applicator deforming and flexing to thereby conform to the contours of the patient's body and complete an electrical circuit through the skin via said circuit to allow migration of said at least one medicament from said plurality of juxtaposed reservoir units through said skin and into the blood stream of the patient.

Claim 23

A conformable, pliable, and relatively thin transdermal drug applicator for electrophoresis or electroosmosis of at least one medicament through the skin and into the blood stream of a patient comprising: (a) a plurality of juxtaposed flexible drug reservoir units forming a cell-like network, said plurality of juxtaposed flexible drug reservoir units having at least one medicament in at least one of said plurality of juxtaposed flexible drug reservoir units; (b) a power source coupled to said plurality of juxtaposed flexible drug reservoir units, said power source having a circuit including a battery, said circuit configured to electrically connect said battery to said at least one medicament in at least one of said plurality of juxtaposed flexible drug reservoir units; (c) a flexible, insulative and hydrophobic material surrounding said plurality of flexible drug reservoir units and said power source while leaving common sides of said plurality of flexible drug reservoir units being adapted for contacting the skin, said flexible, insulative and hydrophobic material precluding shorting of said plurality of flexible reservoir units while aiding in providing flexibility to the applicator; and (d) a flexible cover substantially surrounding said plurality of juxtaposed flexible drug reservoir units, said power source, and said flexible insulative and hydrophobic material while leaving common sides of said plurality of juxtaposed flexible drug reservoir units adapted for contacting the skin, said flexible cover being provided with a peripheral lip formed to releaseably cooperate with the patient's tissue while allowing the transdermal drug applicator to be mounted and retained on the skin, said flexible cover in combination with said plurality of flexible reservoir units and said insulative and hydrophobic material allowing said applicator to easily compensate for movement of the skin, the conformability of the transdermal drug applicator increasing with the number of said plurality of juxtaposed flexible reservoir units and amount of said insulative and hydrophobic material provided within the transdermal drug applicator, while said applicator deforming and flexing to thereby conform to the contours of the patient's body and complete an electrical circuit through the skin via said circuit to allow migration of said at least one medicament from said plurality of juxtaposed reservoir units through said skin and into the blood stream of the patient.

Claim 24

The transdermal drug applicator of claim 20, in which said plurality of reservoir means are made from a microporous material whereby said at least one medicament provides an electrical path therethrough.

Claim 25

The transdermal drug applicator of claim 21; further including in said electrical circuit means to maintain constant current flowing during the period said at least one medicament is being delivered.

Claim 26

The transdermal drug applicator of claim 20, wherein said plurality of reservoirs are adjacently disposed.

Claim 27

The transdermal drug applicator of claim 20, wherein said plurality of reservoirs are spaced apart from each other.

Claim 28

The transdermal drug applicator of claim 20, wherein said means for separating said plurality of reservoir units from each other comprises a non-conductive hydrophobic gel.

Claim 29

The transdermal drug applicator of claim 20, wherein said plurality of reservoirs means are two.

Claim 30

The transdermal drug applicator of claim 20, wherein said overall grid pattern is configured as a rectangle.

Claim 31

The transdermal drug applicator of claim 20, wherein said overall grid pattern is configured a pair of halves.

Claim 32

The transdermal drug applicator according to claim 28, wherein each of said pair of halves is configured as a rectangle.

Claim 33

The transdermal drug applicator according to claim 28, wherein each of said pair of halves is configured as a semi-oval.

Claim 34

The transdermal drug applicator of claim 20, wherein said overall grid pattern is in the shape of a plurality of petals.