Patent US6132755A successfully refreshed from Google Patents.
US6132755A
Expired / Lapsed
US
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Transcorneal drug-release system
Assignee: Boehringer Ingelheim GmbH
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Filing: 1996-07-15
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Granted: 2000-10-17
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Expires: 2016-07-15
Abstract
Abstract The invention refers to a transcorneal system for the actively controlled transcorneal delivery of a medicament into a subject comprising an active substance reservoir and a device provided with a plurality of micro-pins or micro-blades adapted in use to penetrate the stratum corneum of the subject and connected with reservoir via a liquid conveying connection and thereby allow active substance to pass from the reservoir through capillary openings of the micro-pins or along the micro-blades into the subject.
Inventors
- 👤 Joachim Eicher
- 👤 Bernd Zierenberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 02:42
CPC Classifications
A; A61; A61M; A61M37/00; A61M37/0015; A61M31/00; A61M31/002; A61M2037/0007; A61M2037/0023; A61M2037/003
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
123 words
A transcorneal system for controlled transcorneal delivery of a medicament into a warm-blooded animal comprising: a) an active substance reservoir comprising a drug -containing liquid ; b) a device, which device is provided with micro-blades which are capable of penetrating the stratum corneum of the animal and which device is also provided with a liquid-conveying means, whereby the device is connected to the reservoir via its liquid-conveying means to allow drug-containing liquid to pass from the reservoir to the micro-blades; and c) a means for actively controlling the passing of drug-containing liquid from the reservoir to the micro-blades, wherein the means for actively controlling the passing of drug-containing liquid from the reservoir to the micro-blades is an integrated pump with integrated electronic controls.
Claim 2
Dependent Claim
123 words
A transcorneal system for controlled transcorneal delivery of a medicament into a warm-blooded animal comprising: a) an active substance reservoir comprising a drug -containing liquid ; b) a device, which device is provided with micro-blades which are capable of penetrating the stratum corneum of the animal and which device is also provided with a liquid-conveying means, whereby the device is connected to the reservoir via its liquid-conveying means to allow drug-containing liquid to pass from the reservoir to the micro-blades; and c) a means for actively controlling the passing of drug-containing liquid from the reservoir to the micro-blades, wherein the means for actively controlling the passing of drug-containing liquid from the reservoir to the micro-blades is an integrated pump with integrated electronic controls.
Claim 3
Dependent Claim
127 words
A transcorneal system for controlled transcorneal delivery of a medicament into a warm-blooded animal comprising: a) an active substance reservoir comprising a drug-containing liquid; b) a device, which device is provided with a plurality of micro-pins which are capable of penetrating the stratum corneum and which micro-pins have capillary openings at both ends and hollow spaces within the micro-pins and which device is connected to the reservoir via the capillary opening at one end of each of the micro-pins and is adjacent the stratum corneum at the opposite end of each of the micro-pins; and c) a means for actively discharging the drug-containing liquid from the reservoir through the micro-pins, wherein the means for actively discharging the drug-containing liquid is an integrated pump with integrated electronic controls.
Claim 4
Dependent Claim
127 words
A transcorneal system for controlled transcorneal delivery of a medicament into a warm-blooded animal comprising: a) an active substance reservoir comprising a drug-containing liquid; b) a device, which device is provided with a plurality of micro-pins which are capable of penetrating the stratum corneum and which micro-pins have capillary openings at both ends and hollow spaces within the micro-pins and which device is connected to the reservoir via the capillary opening at one end of each of the micro-pins and is adjacent the stratum corneum at the opposite end of each of the micro-pins; and c) a means for actively discharging the drug-containing liquid from the reservoir through the micro-pins, wherein the means for actively discharging the drug-containing liquid is an integrated pump with integrated electronic controls.
Claim 5
Dependent Claim
21 words
The transcorneal system as recited in claim 2, further comprising microvalves between the reservoir and the capillary openings of the micro-pins.
Claim 6
Dependent Claim
21 words
The transcorneal system as recited in claim 2, wherein each micro-pins is provided with capillary openings that have a round cross-section.
Claim 7
Dependent Claim
19 words
The transcorneal system as recited in claim 2, wherein each micro-pin is provided with capillary openings that are slit-like.
Claim 8
Dependent Claim
27 words
The transcorneal system as recited in claim 2, wherein each micro-pin is made of a micro-porous material that is previous to the drug-containing liquid in the reservoir.
Claim 9
Dependent Claim
22 words
The transcorneal system as recited in claim 1, wherein the integrated pump is an electrically driven piezo-electric membrane performing a pump movement.
Claim 10
Dependent Claim
22 words
The transcorneal system as recited in claim 2, wherein the integrated pump is an electrically driven piezo-electric membrane performing a pump movement.
Claim 11
Dependent Claim
20 words
The transcorneal system as recited in claim 1, wherein the reservoir has at least one movable or flexible boundary surface.
Claim 12
Dependent Claim
20 words
The transcorneal system as recited in claim 2, wherein the reservoir has at least one movable or flexible boundary surface.
Claim 13
Dependent Claim
19 words
The transcorneal system as recited in claim 9, wherein the moveable boundary surface is a piston within a cylinder.
Claim 14
Dependent Claim
19 words
The transcorneal system as recited in claim 10, wherein the moveable boundary surface is a piston within a cylinder.
Claim 15
Dependent Claim
16 words
The transcorneal system as recited in claim 9, wherein the flexible boundary surface is a membrane.
Claim 16
Dependent Claim
16 words
The transcorneal system as recited in claim 10, wherein the flexible boundary surface is a membrane.
Claim 17
Dependent Claim
16 words
The transcorneal system as recited in claim 9, wherein the flexible boundary surface is a concertina.
Claim 18
Dependent Claim
16 words
The transcorneal system as recited in claim 10, wherein the flexible boundary surface is a concertina.
Claim 19
Dependent Claim
20 words
The transcorneal system as recited in claim 1, wherein the micro-blades have a length of at least about 10 μm.
Claim 20
Dependent Claim
20 words
The transcorneal system as recited in claim 1, wherein the micro-pins have a length of at least about 10 μm.
Claim 21
Dependent Claim
17 words
The transcorneal system as recited in claim 1, wherein the micro-blades are made of a thermoplastic material.
Claim 22
Dependent Claim
17 words
The transcorneal system as recited in claim 2, wherein the micro-pins are made of a thermoplastic material.
Claim 23
Dependent Claim
25 words
The transcorneal system as recited in claim 2, wherein each micro-pin has a tip with a radius of curvature of less than about 10 μm.
References Cited (Backward Citations)
US3964482A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-10-17 | 2004-04-17 | 2004-10-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-10-17 | 2008-04-17 | 2008-10-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-10-17 | 2012-04-17 | 2012-10-17 | $7700.00 | Window Closed / Lapsed |