US6236870B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Photonic molecular probe
Assignee: Xoetronics LLC
•
Filing: 1999-02-12
•
Granted: 2001-05-22
•
Expires: 2019-02-12
Abstract
Abstract An opto-electronic device utilizes a band of polychromatic light for quantitative analysis of a target molecule within a mixed specimen. A movable polarizer produces a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light. A specimen cell adapted for receiving the mixed specimen transports the segmented band of partially polarized polychromatic light to the mixed specimen. A movable polarizing analyzer is optically coupled to the segmented band of partially polarized polychromatic light exiting the mixed specimen. The segmented band of partially polarized polychromatic light before entering the mixed specimen is compared with the segmented band of partially polarized polychromatic light after exiting the mixed specimen. The movable polarizer is synchronized with the movable polarizing analyzer. Additionally a frequency filter can be optically coupled to the movable polarizer, where the frequency filter produces a beam of single frequency ellipitically polarized light from the band of partially polarized polychromatic light such that the segmented band of partially polarized polychromatic light is a segmented band of ellipitically polarized light.
Inventors
- 👤 Frank Madarasz
- 👤 Darell Engelhaupt
- 👤 James Wyly
- 👤 Joseph Milelli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 18:02
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/14558; G; G01; G01N; G01N21/00; G01N21/17; G01N21/21; A61B5/72; A61B5/7203; A61B5/7235; A61B5/7253; A61B5/726
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
150 words
An opto-electronic device utilizing a band of partially polarized polychromatic light for quantitative analysis of a specimen containing a target molecule, the device comprising: a polarizer for producing a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light; a specimen cell adapted for receiving the specimen and for transporting the segmented band of partially polarized polychromatic light to the specimen; an RF source coupled to the specimen cell whereby the RF source causes particular changes of selected achiral molecules within the specimen; a polarizing analyzer optically coupled to the segmented band of partially polarized polychromatic light exiting the specimen; and comparison means for comparing the segmented band of partially polarized polychromatic light before entering the specimen with the segmented band of partially polarized polychromatic light after exiting the specimen, wherein the target molecule changes ellipticity of the segmented band of partially polarized polychromatic light.
Claim 2
Dependent Claim
150 words
An opto-electronic device utilizing a band of partially polarized polychromatic light for quantitative analysis of a specimen containing a target molecule, the device comprising: a polarizer for producing a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light; a specimen cell adapted for receiving the specimen and for transporting the segmented band of partially polarized polychromatic light to the specimen; an RF source coupled to the specimen cell whereby the RF source causes particular changes of selected achiral molecules within the specimen; a polarizing analyzer optically coupled to the segmented band of partially polarized polychromatic light exiting the specimen; and comparison means for comparing the segmented band of partially polarized polychromatic light before entering the specimen with the segmented band of partially polarized polychromatic light after exiting the specimen, wherein the target molecule changes ellipticity of the segmented band of partially polarized polychromatic light.
Claim 3
Dependent Claim
16 words
The device as recited in claim 1 wherein the polarizing analyzer is a movable polarizing analyzer.
Claim 4
Dependent Claim
14 words
The device as recited in claim 2 wherein the polarizer is a movable polarizer.
Claim 5
Dependent Claim
18 words
The device as recited in claim 3 wherein the movable polarizer is synchronized with the movable polarizing analyzer.
Claim 6
Dependent Claim
14 words
The device as recited in claim 3 wherein the movable polarizer is incrementally rotatable.
Claim 7
Dependent Claim
15 words
The device as recited in claim 2 wherein the movable polarizing analyzer is incrementally rotatable.
Claim 8
Dependent Claim
40 words
The device as recited in claim 1 further comprising a frequency filter optically coupled to the polarizer, wherein the frequency filter produces a beam of narrow frequency band of ellipitically polarized light from the band of partially polarized polychromatic light.
Claim 9
Dependent Claim
24 words
The device as recited in claim 1 wherein the band of partially polarized polychromatic light includes frequencies which interact strongly with the target molecule.
Claim 10
Dependent Claim
29 words
The device as recited in claim 1 further comprising a frequency filter for producing a single frequency elliptically polarized light beam from the band of partially polarized polychromatic light.
Claim 11
Dependent Claim
172 words
An opto-electronic device utilizing a band of partially polarized polychromatic light for quantitative analysis of a specimen containing a target molecule, the device comprising: a polarizer for producing a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light; a specimen cell adapted for receiving the specimen and for transporting the segmented band of partially polarized polychromatic light to the specimen; a polarizing analyzer optically coupled to the segmented band of partially polarized polychromatic light exiting the specimen; and comparison means for comparing the segmented band of partially polarized polychromatic light before entering the specimen with the segmented band of partially polarized polychromatic light after exiting the specimen, the comparison means comprises an optical sensor and a signal processor for determining a quantitative level of the target molecule within the specimen and the signal processor utilizes Bayesian parameter estimation theory for determining the quantitative level of the target molecule within the specimen; wherein the target molecule changes ellipticity of the segmented band of partially polarized polychromatic light.
Claim 12
Dependent Claim
172 words
An opto-electronic device utilizing a band of partially polarized polychromatic light for quantitative analysis of a specimen containing a target molecule, the device comprising: a polarizer for producing a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light; a specimen cell adapted for receiving the specimen and for transporting the segmented band of partially polarized polychromatic light to the specimen; a polarizing analyzer optically coupled to the segmented band of partially polarized polychromatic light exiting the specimen; and comparison means for comparing the segmented band of partially polarized polychromatic light before entering the specimen with the segmented band of partially polarized polychromatic light after exiting the specimen, the comparison means comprises an optical sensor and a signal processor for determining a quantitative level of the target molecule within the specimen and the signal processor utilizes Bayesian parameter estimation theory for determining the quantitative level of the target molecule within the specimen; wherein the target molecule changes ellipticity of the segmented band of partially polarized polychromatic light.
Claim 13
Dependent Claim
17 words
The device as recited in claim 10 , wherein the quantitative level corresponds to a glucose level.
Claim 14
Dependent Claim
17 words
The device as recited in claim 10 , wherein the quantitative level corresponds to an ethanol level.
Claim 15
Dependent Claim
18 words
The device as recited in claim 10 , wherein the quantitative level corresponds to a drug serum level.
Claim 16
Dependent Claim
18 words
The device as recited in claim 10 , wherein the quantitative level corresponds to a hormone serum level.
Claim 17
Dependent Claim
17 words
The device as recited in claim 10 , wherein the quantitative level corresponds to a triglycerides level.
Claim 18
Independent Claim
103 words
A method for quantitative analysis of a target molecule within a specimen, the method comprising the steps of: producing elliptical/partially polarized polychromatic light; producing segmented characterized light with a polarizer optically coupled to the elliptical/partially polarized polychromatic light; transporting the segmented characterized light onto and through the specimen; polarizing the segmented characterized light exiting the specimen; and comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen; utilizing Bayesian parameter estimation theory for determining the quantitative level of the target molecule within the specimen: wherein the target molecule changes ellipticity of the segmented characterized light.
Claim 19
Independent Claim
103 words
A method for quantitative analysis of a target molecule within a specimen, the method comprising the steps of: producing elliptical/partially polarized polychromatic light; producing segmented characterized light with a polarizer optically coupled to the elliptical/partially polarized polychromatic light; transporting the segmented characterized light onto and through the specimen; polarizing the segmented characterized light exiting the specimen; and comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen; utilizing Bayesian parameter estimation theory for determining the quantitative level of the target molecule within the specimen: wherein the target molecule changes ellipticity of the segmented characterized light.
Claim 20
Dependent Claim
17 words
The method as recited in claim 16 , wherein the quantitative level corresponds to a glucose level.
Claim 21
Dependent Claim
17 words
The method as recited in claim 16 , wherein the quantitative level corresponds to an ethanol level.
Claim 22
Dependent Claim
18 words
The method as recited in claim 16 , wherein the quantitative level corresponds to a drug serum level.
Claim 23
Dependent Claim
18 words
The method as recited in claim 16 , wherein the quantitative level corresponds to a hormone serum level.
Claim 24
Dependent Claim
17 words
The method as recited in claim 16 , wherein the quantitative level corresponds to a triglycerides level.
Claim 25
Independent Claim
107 words
A method for quantitative analysis of a target molecule within a specimen, the method comprising the steps of: producing elliptical/partially polarized polychromatic light; producing segmented characterized light with a polarizer optically coupled to the elliptical/partially polarized polychromatic light; coupling an RF source to the specimen whereby the RF source causes particular changes of selected achiral molecules within the specimen; transporting the segmented characterized light onto and through the specimen; polarizing the segmented characterized light exiting the specimen; and comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen, wherein the target molecule changes ellipticity of the segmented characterized light.
Claim 26
Independent Claim
107 words
A method for quantitative analysis of a target molecule within a specimen, the method comprising the steps of: producing elliptical/partially polarized polychromatic light; producing segmented characterized light with a polarizer optically coupled to the elliptical/partially polarized polychromatic light; coupling an RF source to the specimen whereby the RF source causes particular changes of selected achiral molecules within the specimen; transporting the segmented characterized light onto and through the specimen; polarizing the segmented characterized light exiting the specimen; and comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen, wherein the target molecule changes ellipticity of the segmented characterized light.
Claim 27
Dependent Claim
165 words
An opto-electronic device utilizing a band of partially polarized polychromatic light for quantitative analysis of a specimen containing various target molecules, the device comprising: a polarizer for producing a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light; a specimen cell adapted for receiving the specimen and for transporting the segmented band of partially polarized polychromatic light to the specimen; an RF source coupled to the specimen cell whereby the RF source causes particular changes of selected achiral molecules within the specimen; a polarizing analyzer optically coupled to the segmented band of partially polarized polychromatic light exiting the specimen; and comparison means for comparing the segmented band of partially polarized polychromatic light before entering the specimen with the segmented band of partially polarized polychromatic light after exiting the specimen, wherein each target molecule of the various target molecules distinctly changes ellipticity of the segmented band of partially polarized polychromatic light as a function of concentration of the target molecule.
Claim 28
Dependent Claim
165 words
An opto-electronic device utilizing a band of partially polarized polychromatic light for quantitative analysis of a specimen containing various target molecules, the device comprising: a polarizer for producing a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light; a specimen cell adapted for receiving the specimen and for transporting the segmented band of partially polarized polychromatic light to the specimen; an RF source coupled to the specimen cell whereby the RF source causes particular changes of selected achiral molecules within the specimen; a polarizing analyzer optically coupled to the segmented band of partially polarized polychromatic light exiting the specimen; and comparison means for comparing the segmented band of partially polarized polychromatic light before entering the specimen with the segmented band of partially polarized polychromatic light after exiting the specimen, wherein each target molecule of the various target molecules distinctly changes ellipticity of the segmented band of partially polarized polychromatic light as a function of concentration of the target molecule.
Claim 29
Dependent Claim
16 words
The device as recited in claim 23 wherein the polarizing analyzer is a movable polarizing analyzer.
Claim 30
Dependent Claim
14 words
The device as recited in claim 24 wherein the polarizer is a movable polarizer.
Claim 31
Dependent Claim
18 words
The device as recited in claim 25 wherein the movable polarizer is synchronized with the movable polarizing analyzer.
Claim 32
Dependent Claim
14 words
The device as recited in claim 25 wherein the movable polarizer is incrementally rotatable.
Claim 33
Dependent Claim
15 words
The device as recited in claim 24 wherein the movable polarizing analyzer is incrementally rotatable.
Claim 34
Dependent Claim
40 words
The device as recited in claim 23 further comprising a frequency filter optically coupled to the polarizer, wherein the frequency filter produces a beam of narrow frequency band of ellipitically polarized light from the band of partially polarized polychromatic light.
Claim 35
Dependent Claim
24 words
The device as recited in claim 23 wherein the band of partially polarized polychromatic light includes frequencies which interact strongly with the target molecule.
Claim 36
Dependent Claim
29 words
The device as recited in claim 23 further comprising a frequency filter for producing a single frequency elliptically polarized light beam from the band of partially polarized polychromatic light.
Claim 37
Dependent Claim
187 words
An opto-electronic device utilizing a band of partially polarized polychromatic light for quantitative analysis of a specimen containing various target molecules, the device comprising: a polarizer for producing a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light; a specimen cell adapted for receiving the specimen and for transporting the segmented band of partially polarized polychromatic light to the specimen; a polarizing analyzer optically coupled to the segmented band of partially polarized polychromatic light exiting the specimen; and comparison means for comparing the segmented band of partially polarized polychromatic light before entering the specimen with the segmented band of partially polarized polychromatic light after exiting the specimen, the comparison means comprises an optical sensor and a signal processor for determining a quantitative level of the target molecule within the specimen and the signal processor utilizes Bayesian parameter estimation theory for determining the quantitative level of the target molecule within the specimen; wherein each target molecule of the various target molecules distinctly changes ellipticity of the segmented band of partially polarized polychromatic light as a function of concentration of the target molecule.
Claim 38
Dependent Claim
187 words
An opto-electronic device utilizing a band of partially polarized polychromatic light for quantitative analysis of a specimen containing various target molecules, the device comprising: a polarizer for producing a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light; a specimen cell adapted for receiving the specimen and for transporting the segmented band of partially polarized polychromatic light to the specimen; a polarizing analyzer optically coupled to the segmented band of partially polarized polychromatic light exiting the specimen; and comparison means for comparing the segmented band of partially polarized polychromatic light before entering the specimen with the segmented band of partially polarized polychromatic light after exiting the specimen, the comparison means comprises an optical sensor and a signal processor for determining a quantitative level of the target molecule within the specimen and the signal processor utilizes Bayesian parameter estimation theory for determining the quantitative level of the target molecule within the specimen; wherein each target molecule of the various target molecules distinctly changes ellipticity of the segmented band of partially polarized polychromatic light as a function of concentration of the target molecule.
Claim 39
Dependent Claim
17 words
The device as recited in claim 32 , wherein the quantitative level corresponds to a glucose level.
Claim 40
Dependent Claim
17 words
The device as recited in claim 32 , wherein the quantitative level corresponds to an ethanol level.
Claim 41
Dependent Claim
18 words
The device as recited in claim 32 , wherein the quantitative level corresponds to a drug serum level.
Claim 42
Dependent Claim
18 words
The device as recited in claim 32 , wherein the quantitative level corresponds to a hormone serum level.
Claim 43
Dependent Claim
17 words
The device as recited in claim 32 , wherein the quantitative level corresponds to a triglycerides level.
Claim 44
Independent Claim
118 words
A method for quantitative analysis of various target molecules within a specimen, the method comprising the steps of: producing elliptical/partially polarized polychromatic light; producing segmented characterized light with a polarizer optically coupled to the elliptical/partially polarized polychromatic light; transporting the segmented characterized light onto and through the specimen; polarizing the segmented characterized light exiting the specimen; and comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen; utilizing Bayesian parameter estimation theory for determining the quantitative level of the target molecule within the specimen, wherein each target molecule of the various target molecules distinctly changes ellipticity of the segmented characterized light as a function of concentration of the target molecule.
Claim 45
Independent Claim
118 words
A method for quantitative analysis of various target molecules within a specimen, the method comprising the steps of: producing elliptical/partially polarized polychromatic light; producing segmented characterized light with a polarizer optically coupled to the elliptical/partially polarized polychromatic light; transporting the segmented characterized light onto and through the specimen; polarizing the segmented characterized light exiting the specimen; and comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen; utilizing Bayesian parameter estimation theory for determining the quantitative level of the target molecule within the specimen, wherein each target molecule of the various target molecules distinctly changes ellipticity of the segmented characterized light as a function of concentration of the target molecule.
Claim 46
Dependent Claim
17 words
The method as recited in claim 38 , wherein the quantitative level corresponds to a glucose level.
Claim 47
Dependent Claim
17 words
The method as recited in claim 38 , wherein the quantitative level corresponds to an ethanol level.
Claim 48
Dependent Claim
18 words
The method as recited in claim 38 , wherein the quantitative level corresponds to a drug serum level.
Claim 49
Dependent Claim
18 words
The method as recited in claim 38 , wherein the quantitative level corresponds to a hormone serum level.
Claim 50
Dependent Claim
17 words
The method as recited in claim 38 , wherein the quantitative level corresponds to a triglycerides level.
Claim 51
Independent Claim
122 words
A method for quantitative analysis of various target molecules within a specimen, the method comprising the steps of: producing elliptical/partially polarized polychromatic light; producing segmented characterized light with a polarizer optically coupled to the elliptical/partially polarized polychromatic light; coupling an RF source to the specimen whereby the RF source causes particular changes of selected achiral molecules within the specimen; transporting the segmented characterized light onto and through the specimen; polarizing the segmented characterized light exiting the specimen; and comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen, wherein each target molecule of the various target molecules distinctly changes ellipticity of the segmented characterized light as a function of concentration of the target molecule.
Claim 52
Independent Claim
122 words
A method for quantitative analysis of various target molecules within a specimen, the method comprising the steps of: producing elliptical/partially polarized polychromatic light; producing segmented characterized light with a polarizer optically coupled to the elliptical/partially polarized polychromatic light; coupling an RF source to the specimen whereby the RF source causes particular changes of selected achiral molecules within the specimen; transporting the segmented characterized light onto and through the specimen; polarizing the segmented characterized light exiting the specimen; and comparing the segmented characterized light before entering the specimen with the segmented characterized light after exiting the specimen, wherein each target molecule of the various target molecules distinctly changes ellipticity of the segmented characterized light as a function of concentration of the target molecule.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2004-05-21 | 2004-11-20 | 2005-05-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-05-21 | 2008-11-20 | 2009-05-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-05-21 | 2012-11-20 | 2013-05-22 | $7700.00 | Window Closed / Lapsed |