Patent US6325987B1 successfully refreshed from Google Patents.
US6325987B1
Expired / Lapsed
US
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Minerals and methods for their production and use
Assignee: PAUL ROYALTY FUND LP
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Filing: 1999-04-21
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Granted: 2001-12-04
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Expires: 2019-04-21
Abstract
Abstract Uniformly sized and shaped particles of metal salts are provided comprised of one or more metal cations in combination with one or more simple oxoacid anions and a general method for the controlled precipitation of said metal salts from aqueous solutions. The methods proceed via the in situ homogeneous production of simple or complex oxoacid anions in which one or more of the nonmetallic elements e.g. Group 5B and 6B (chalcogenides), and 7B (halides) comprising the first oxoacid anion undergo oxidation to generate the precipitant anionic species along with concurrent reduction of the nonmetallic element of a second, dissimilar oxoacid anion. The oxoacid anions are initially present in solution with one or more metal cations known to form insoluble salts with the precipitant anion.
Inventors
- 👤 Ronald S. Sapieszko
- 👤 Erik M. Erbe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:26
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/02; A61L27/12; A61K; A61K6/00; A61K6/15; A61K6/17; A61K6/60; A61K6/69; A61K6/70; A61K6/71; A61K6/74; A61K6/75; A61K6/77; A61K6/78; A61K6/80; A61K6/831; A61K6/833; A61K6/849; A61K6/864; A61L24/00; A61L24/02; C; C01; C01B; C01B25/00; C01B25/16; C01B25/26; C01B25/32; C01B25/324; C01B25/36; C01B25/37; C01B25/375; A61F; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
105 words
A substantially homogeneous calcium phosphate salt that is an oxidation-reduction product formed by: preparing an aqueous solution comprising: a metal cation which is calcium; at least one oxidizing agent; and at least one precursor anion oxidizable by said oxidizing agent to form a phosphate; and heating said solution under conditions of temperature and pressure effective to initiate an oxidation-reduction reaction between said oxidizing agent and the precursor anion; said reaction evolving at least one gaseous product; and giving rise to said phosphates said metal phosphate, salt precipitating from said solution, and comprised of individual crystallites having a crystal size of about 1 micron or below.
Claim 2
Dependent Claim
105 words
A substantially homogeneous calcium phosphate salt that is an oxidation-reduction product formed by: preparing an aqueous solution comprising: a metal cation which is calcium; at least one oxidizing agent; and at least one precursor anion oxidizable by said oxidizing agent to form a phosphate; and heating said solution under conditions of temperature and pressure effective to initiate an oxidation-reduction reaction between said oxidizing agent and the precursor anion; said reaction evolving at least one gaseous product; and giving rise to said phosphates said metal phosphate, salt precipitating from said solution, and comprised of individual crystallites having a crystal size of about 1 micron or below.
Claim 3
Dependent Claim
11 words
The calcium phosphate salt of claim 1 having substantially uniform morphology.
Claim 4
Dependent Claim
11 words
The calcium phosphate salt of claim 1 having a non-stoichiometric composition.
Claim 5
Dependent Claim
90 words
Substantially homogeneous, bioactive and biocompatible calcium phosphate that is an oxidation-reduction product produced by: preparing an aqueous solution of a phosphorus oxoacid and a calcium nitrate; heating said solution to a temperature of about 250° C. or below under conditions of temperature and pressure effective to initiate an oxidation-reduction reaction between the oxoacid and the calcium nitrate; said reaction evolving nitrogen oxide gas; and said calcium phosphate precipitating from said solution wherein said calcium phosphate is comprised of individual crystallites have a crystal size of about 1 μm or below.
Claim 6
Dependent Claim
90 words
Substantially homogeneous, bioactive and biocompatible calcium phosphate that is an oxidation-reduction product produced by: preparing an aqueous solution of a phosphorus oxoacid and a calcium nitrate; heating said solution to a temperature of about 250° C. or below under conditions of temperature and pressure effective to initiate an oxidation-reduction reaction between the oxoacid and the calcium nitrate; said reaction evolving nitrogen oxide gas; and said calcium phosphate precipitating from said solution wherein said calcium phosphate is comprised of individual crystallites have a crystal size of about 1 μm or below.
Claim 7
Dependent Claim
21 words
The calcium phosphate produced in accordance with claim 4 being further derived by heating to a temperature above about 100° C.
Claim 8
Dependent Claim
20 words
The calcium phosphate produced in accordance with claim 5 wherein said heating is to a temperature below about 700° C.
Claim 9
Dependent Claim
16 words
The bioactive and biocompatible calcium phosphate of claim 4 wherein said phosphorus oxoacid is hypophosphorus acid.
Claim 10
Dependent Claim
20 words
A bioactive cement for the repair of osseous defects comprising the bioactive and biocompatible calcium phosphate of claim 4 .
Claim 11
Dependent Claim
17 words
The bioactive and biocompatible calcium phosphate of claim 4 admixed with a pharmaceutically acceptable carrier or diluent.
Claim 12
Dependent Claim
14 words
The bioactive and biocompatible calcium phosphate of claim 4 admixed with a polymerizable material.
Claim 13
Dependent Claim
118 words
An alkaline earth phosphate salt of an oxidation-reduction product formed by: preparing an aqueous solution comprising an alkaline earth cation; at least one oxidizing agent; and at least one precursor anion oxidizable by said oxidizing agent to form a phosphate; and heating said solution under conditions of temperature and pressure effective to initiate an oxidation-reduction reaction between said oxidizing agent and the precursor anion, said reaction evolving at least one gaseous product; and giving rise to said phosphate, said alkaline earth metal phosphate salt precipitating from said solution wherein said alkaline earth metal phosphate salt is substantially homogeneous and has a substantially fine crystal size of about 1 μm or below, wherein said alkaline earth metal is calcium.
Claim 14
Dependent Claim
118 words
An alkaline earth phosphate salt of an oxidation-reduction product formed by: preparing an aqueous solution comprising an alkaline earth cation; at least one oxidizing agent; and at least one precursor anion oxidizable by said oxidizing agent to form a phosphate; and heating said solution under conditions of temperature and pressure effective to initiate an oxidation-reduction reaction between said oxidizing agent and the precursor anion, said reaction evolving at least one gaseous product; and giving rise to said phosphate, said alkaline earth metal phosphate salt precipitating from said solution wherein said alkaline earth metal phosphate salt is substantially homogeneous and has a substantially fine crystal size of about 1 μm or below, wherein said alkaline earth metal is calcium.
Claim 15
Dependent Claim
13 words
The alkaline earth metal phosphate salt of claim 11 having a non-stoichiometric composition.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-12-03 | 2005-06-04 | 2005-12-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-12-03 | 2009-06-04 | 2009-12-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-12-03 | 2013-06-04 | 2013-12-04 | $7700.00 | Window Closed / Lapsed |