Patent US6503556B2 successfully refreshed from Google Patents.
US6503556B2
Expired / Lapsed
US
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Methods of forming a coating for a prosthesis
Assignee: Abbott Cardiovascular Systems Inc
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Filing: 2000-12-28
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Granted: 2003-01-07
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Expires: 2020-12-28
Abstract
Abstract Methods of forming a coating onto an implantable device or endoluminal prosthesis, such as a stent, are provided. The coating may be used for the delivery of an active ingredient. The coating may have a selected pattern of interstices for allowing a fluid to seep through the coating in the direction of the pattern created.
Inventors
- 👤 Sameer Harish
- 👤 Steven Wu
- 👤 Deborra Sanders Millare
- 👤 Judy Guruwaiya
- 👤 Stephen Pacetti
- 👤 Syed Faiyaz Ahmed Hossainy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 11:29
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/16; A61L31/08; A61L31/10; A61L2300/00; A61L2300/40; A61L2300/416; A61L2300/60; A61L2300/602; A61L2300/606
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
98 words
A method of forming a coating for a metallic prosthesis, comprising: depositing a sheath including a thermoplastic polymer over at least a portion of a metallic prosthesis, said prosthesis having a plurality of interconnected struts separated by gaps and a longitudinally extending central bore for allowing a fluid to travel through said prosthesis; and exposing said polymer to a sufficient temperature equal to or greater than the glass transition temperature and not greater than about the melting temperature of said polymer effective to cause said sheath to adhere to said prosthesis to form a coating for said prosthesis.
Claim 2
Independent Claim
98 words
A method of forming a coating for a metallic prosthesis, comprising: depositing a sheath including a thermoplastic polymer over at least a portion of a metallic prosthesis, said prosthesis having a plurality of interconnected struts separated by gaps and a longitudinally extending central bore for allowing a fluid to travel through said prosthesis; and exposing said polymer to a sufficient temperature equal to or greater than the glass transition temperature and not greater than about the melting temperature of said polymer effective to cause said sheath to adhere to said prosthesis to form a coating for said prosthesis.
Claim 3
Dependent Claim
15 words
The method of claim 1 , wherein said coating covers said gaps underlying said sheath.
Claim 4
Dependent Claim
48 words
The method of claim 1 , wherein said method further comprises: removing a portion of said coating positioned over some of said gaps to form a pattern of interstices dispersed between said struts for allowing a fluid that flows through said central bore to seep through said coating.
Claim 5
Dependent Claim
25 words
The method of claim 3 , wherein said removing is performed by applying a laser discharge to said coating to form said pattern of interstices.
Claim 6
Dependent Claim
24 words
The method of claim 1 , wherein said polymer comprises polycaprolactone, poly(lactide-co-glycolide), poly(hydroxybutyrate), ethylene vinyl acetate, polyvinyl alcohol or an ethylene vinyl alcohol copolymer.
Claim 7
Dependent Claim
57 words
The method of claim 1 , wherein said coating is impregnated with an active ingredient for the sustained release of said active ingredient when said prosthesis is implanted in a biological passageway, and wherein said active ingredient is selected from a group of antiproliferative, antineoplastic, antiinflanmatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antibiotic, antioxidant substances and combinations thereof.
Claim 8
Dependent Claim
19 words
The method of claim 6 , wherein said method further comprises: forming a rate limiting membrane over said coating.
Claim 9
Dependent Claim
15 words
The method of claim 1 , wherein said coating contains actinomycin D, docetaxel, or paclitaxel.
Claim 10
Dependent Claim
22 words
The method of claim 1 , wherein said coating contains a material selected from a group of radioactive isotopes and radiopaque elements.
Claim 11
Dependent Claim
48 words
The method of claim 1 , wherein said method further comprises: forming a second coating onto said coating on said prosthesis, wherein said second coating is impregnated with an active ingredient for the sustained release of said active ingredient when said prosthesis is implanted in a biological passageway.
Claim 12
Independent Claim
134 words
A method for increasing an amount of a polymeric coating on a stent having struts separated by gaps, without increasing the thickness of the coating, comprising: inserting a stent comprising a metallic material and having a plurality of interconnected struts separated by gaps into a sheath including a thermoplastic polymer; and exposing said polymer to a sufficient temperature equal to or greater than the glass transition temperature of said polymer and not greater than about the melting temperature of said polymer effective to cause said sheath to adhere to said stent to form a coating for said stent, wherein said coating covers said struts and said gaps between said struts so as to increase the quantity of said polymeric coating supported by said stent without increasing the thickness of said coating on said stent.
Claim 13
Independent Claim
134 words
A method for increasing an amount of a polymeric coating on a stent having struts separated by gaps, without increasing the thickness of the coating, comprising: inserting a stent comprising a metallic material and having a plurality of interconnected struts separated by gaps into a sheath including a thermoplastic polymer; and exposing said polymer to a sufficient temperature equal to or greater than the glass transition temperature of said polymer and not greater than about the melting temperature of said polymer effective to cause said sheath to adhere to said stent to form a coating for said stent, wherein said coating covers said struts and said gaps between said struts so as to increase the quantity of said polymeric coating supported by said stent without increasing the thickness of said coating on said stent.
Claim 14
Dependent Claim
59 words
The method of claim 11 , further comprising: removing a portion of said coating deposited over at least one of said gaps to create an opening in said coating, wherein the size of said opening is smaller than the size of said gap, and wherein said opening allows a fluid to travel through said coating from within said stent.
Claim 15
Dependent Claim
26 words
The method of claim 12 , wherein said act of removing comprises: applying a laser discharge to said coating to create said opening in said coating.
Claim 16
Dependent Claim
17 words
The method of claim 11 , wherein said polymeric coating comprises an active ingredient to inhibit restenosis.
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