US6567705B1
Expired / Lapsed
US
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System and method for enhancing cardiac signal sensing by cardiac pacemakers through genetic treatment
Assignee: Medtronic Inc
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Filing: 2000-02-28
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Granted: 2003-05-20
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Expires: 2020-02-28
Abstract
Abstract Delivery systems for and methods of delivering ion channel protein genetic material to cardiac cells in areas adjacent to where an electrode is to be positioned in a patient's heart to improve or correct the signal to noise ratio of cardiac signals, such as the P-wave, is described herein. More specifically, there is provided a system and method for delivering sodium ion channel proteins or nucleic acid molecules encoding sodium ion channel proteins to a site in the heart adjacent to an electrode to increase the expression of the same, thereby enhancing the cardiac signal amplitude and enabling improved sensing of cardiac signals by an implanted pacemaker.
Inventors
- 👤 Kenneth B. Stokes
- 👤 Josée Morissette
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 02:21
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/36; A61N1/362; A61N1/37; A61N1/3702; A61M; A61M37/00; A61N1/02; A61N1/04; A61N1/05; A61N1/056; A61N1/0565; A61N1/0568; A61N1/057; A61N1/0573; A61N1/0575; A61B; A61B17/00; A61B17/34; A61B17/3468; A61K; A61K48/00; A61M25/00; A61M25/0043; A61M2025/0057; A61M25/0067; A61M25/0082; A61M25/0084; A61M2025/0089; A61N2001/058
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
89 words
A delivery system for delivering a predetermined genetic material or protein to myocardial cells of a selected location of a patient's heart, comprising: a sensor for locating an area of inadequate P-wave production in the heart of a patient; and a delivery means for delivering a supply of said genetic material or protein to said selected location in said patients heart wherein said genetic material is selected from the group consisting of DNA encoding an ion channel protein, RNA encoding an ion channel protein, and an ion channel protein.
Claim 2
Dependent Claim
89 words
A delivery system for delivering a predetermined genetic material or protein to myocardial cells of a selected location of a patient's heart, comprising: a sensor for locating an area of inadequate P-wave production in the heart of a patient; and a delivery means for delivering a supply of said genetic material or protein to said selected location in said patients heart wherein said genetic material is selected from the group consisting of DNA encoding an ion channel protein, RNA encoding an ion channel protein, and an ion channel protein.
Claim 3
Dependent Claim
15 words
The delivery system of claim 1 , wherein said delivery means further comprises a catheter.
Claim 4
Dependent Claim
14 words
The delivery system of claim 1 , wherein said catheter is an endocardial catheter.
Claim 5
Dependent Claim
17 words
The delivery system of claim 2 , wherein said delivery means comprises a hollow helical screw-in element.
Claim 6
Dependent Claim
22 words
The delivery system of claim 1 , wherein said supply of genetic material is provided as a bolus to said selected location.
Claim 7
Dependent Claim
16 words
The delivery system of claim 1 , wherein the delivery means forms part of the sensor.
Claim 8
Dependent Claim
17 words
The delivery system of claim 1 , where the delivery means is not part of the sensor.
Claim 9
Dependent Claim
23 words
The deivery system of claim 1 , wherein said selected genetic material is a recombinant nucleic acid molecule encoding the ion channel protein.
Claim 10
Dependent Claim
17 words
The delivery system of claim 8 , wherein said ion channel protein is a sodium channel protein.
Claim 11
Dependent Claim
13 words
The delivery system of claim 9 , wherein sodium channel protein is hH1.
Claim 12
Dependent Claim
24 words
The delivery system of claim 1 , wherein said genetic material or protein increases the amplitude of the cardiac signal of said patient's heart.
Claim 13
Dependent Claim
80 words
An implantable delivery system for delivering doses of predetermined genetic material or protein to myocardial cells in a chosen location of a patient's heart, comprising: a sensor for detecting cardiac signals from said chosen location; a supply of genetic material or protein selected from group consisting of DNA encoding an ion channel protein, RNA encoding an ion channel protein, and an ion channel protein; and an implantable delivery means for delivering said genetic material or protein to said chosen location.
Claim 14
Dependent Claim
80 words
An implantable delivery system for delivering doses of predetermined genetic material or protein to myocardial cells in a chosen location of a patient's heart, comprising: a sensor for detecting cardiac signals from said chosen location; a supply of genetic material or protein selected from group consisting of DNA encoding an ion channel protein, RNA encoding an ion channel protein, and an ion channel protein; and an implantable delivery means for delivering said genetic material or protein to said chosen location.
Claim 15
Dependent Claim
22 words
The implantable delivery system as described in claim 12 , further comprising a control means for controlling operation of said delivery means.
Claim 16
Dependent Claim
20 words
The implantable delivery system of claim 12 , wherein said controlling means controls the rate of delivery of said doses.
Claim 17
Dependent Claim
23 words
The implantable delivery system of claim 12 , wherein said control means comprises automatic means for automatically initiating delivery of said genetic material.
Claim 18
Dependent Claim
24 words
The delivery system of claim 12 , wherein said genetic material or protein increases the amplitude of the cardiac signal of said patient's heart.
Claim 19
Dependent Claim
22 words
The delivery system of claim 12 , wherein said supply of genetic material is provided as a bolus to said selected location.
Claim 20
Dependent Claim
23 words
The delivery system of claim 12 , wherein said selected general material is a recombinant nucleic acid molecule encoding the ion channel protein.
Claim 21
Dependent Claim
17 words
The delivery system of claim 18 , wherein said ion channel protein is a sodium channel protein.
Claim 22
Dependent Claim
14 words
The delivery system of claim 19 , wherein said sodium channel protein is hH1.
Claim 23
Dependent Claim
97 words
An implantable delivery system for delivering predetermined genetic material or protein to cardiac cells adjacent to a pacing electrode positioned in the heart of a patient, comprising: a supply of genetic material or protein selected from the group consisting of DNA encoding an ion channel protein, RNA encoding an ion channel protein, and an ion channel protein; a pacing electrode adapted to be positioned in the heart of a patient; and a delivery means for delivering said genetic material or protein to said cardiac cells adjacent to said pacing electrode positioned in the heart of a patient.
Claim 24
Dependent Claim
97 words
An implantable delivery system for delivering predetermined genetic material or protein to cardiac cells adjacent to a pacing electrode positioned in the heart of a patient, comprising: a supply of genetic material or protein selected from the group consisting of DNA encoding an ion channel protein, RNA encoding an ion channel protein, and an ion channel protein; a pacing electrode adapted to be positioned in the heart of a patient; and a delivery means for delivering said genetic material or protein to said cardiac cells adjacent to said pacing electrode positioned in the heart of a patient.
Claim 25
Dependent Claim
21 words
The implantable delivery system of claim 21 wherein the pacing electrode is positioned against the inner wall of a patient's heart.
Claim 26
Dependent Claim
18 words
The implantable delivery system of claim 21 , wherein said delivery means forms part of said pacing electrode.
Claim 27
Dependent Claim
27 words
The system as described in claim 21 , further comprises a control means for controlling operation of said delivery means to deliver said genetic material or protein.
Claim 28
Dependent Claim
22 words
The implantable delivery system of claim 21 , further comprising a control means for controlling the rate of delivery of said doses.
Claim 29
Dependent Claim
22 words
The implantable delivery system of claim 21 , wherein said control means comprises automatic means for initiating delivery of said genetic material.
Claim 30
Dependent Claim
24 words
The delivery system of claim 21 , wherein said genetic material or protein increases the amplitude of the cardiac signal of said patient's heart.
Claim 31
Dependent Claim
17 words
The delivery system of claim 21 , wherein said delivery means comprises a hollow helical screw-in element.
Claim 32
Dependent Claim
16 words
The delivery system of claim 21 , wherein the delivery means forms part of the sensor.
Claim 33
Dependent Claim
22 words
The delivery system of claim 21 , wherein said supply of genetic material is provided as a bolus to said selected location.
Claim 34
Dependent Claim
23 words
The delivery system of claim 21 , wherein said selected genetic material is a recombinant nucleic acid molecule encoding the ion channel protein.
Claim 35
Dependent Claim
17 words
The delivery system of claim 31 , wherein said ion channel protein is a sodium channel protein.
Claim 36
Dependent Claim
14 words
The delivery system of claim 32 , wherein said sodium channel protein is hH1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-05-19 | 2006-11-18 | 2007-05-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-05-19 | 2010-11-18 | 2011-05-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-05-19 | 2014-11-18 | 2015-05-20 | $7700.00 | Window Closed / Lapsed |