Patent US6679841B2 successfully refreshed from Google Patents.
US6679841B2
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US
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Fluid collection and monitoring device
Assignee: Abbott Laboratories
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Filing: 2001-06-15
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Granted: 2004-01-20
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Expires: 2021-06-15
Abstract
Abstract An article capable of both collecting interstitial fluid and detecting an analyte in that fluid and a method for use of that article. Preferably, the article is also capable of measuring the amount of analyte in the interstitial fluid. The article can be used in conjunction with a meter that contains an appropriate detection element for determining the amount of analyte in the interstitial fluid. In one preferred embodiment, the article is a multiple-layer element comprising:(1) a layer that is capable of being placed in contact with the skin of a patient;(2) a layer that is coated over the skin-contacting layer;(3) a layer, substantially coplanar with the overcoat layer, that is capable of transporting interstitial fluid by means of chemically aided wicking;(4) a layer, overlying the interstitial fluid transporting layer, that is capable of being placed in contact with a meter, said layer having an opening therein through which light can be transmitted;(5) a layer, disposed on the surface of the meter-contacting layer that faces the skin-contyacting layer, that is capable of detecting the presence of analyte or measuring the amount of analyte in the fluid.In order to use the multiple-layer element, light from a source of light is transmitted through the opening in the multiple-layer material to be absorbed at a light-absorbing target on the skin-contacting layer. This light transfers energy to the target, and this transferred energy causes an opening to form in the skin-contacting layer and an opening to form in the stratum corneum. Interstitial fluid exudes from the opening in the stratum corneum and contacts the interstitial fluid transporting layer. The interstitial fluid then moves along or through the interstitial fluid transporting layer to the detecting layer.
Inventors
- 👤 Peter M. Bojan
- 👤 Timothy P. Henning
- 👤 Neil W. Loomis
- 👤 Mark R. Pope
- 👤 Jonathan A. Eppstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 05:04
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1468; A61B5/1486; A61B5/14865; A61B10/00; A61B10/0045; A61B5/14507; A61B5/1451; A61B5/14514; A61B5/15; A61B5/150007; A61B5/150015; A61B5/150022; A61B5/150343; A61B5/150358; A61B5/150755; A61B5/157; A61B18/00; A61B18/18; A61B18/20; A61B2010/008; A61B17/00; A61B2017/00743; A61B2017/00747; A61B2017/00765; A61B2018/1807; A61B2562/00; A61B2562/02; A61B2562/0295; A61B5/44; A61B5/441; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/2575
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
205 words
Method for collecting interstitial fluid and analyzing said fluid for an analyte, said method comprising the steps of: (a) providing a multiple-layer element comprising: (1) a layer that is capable of being placed in contact with the skin of a patient; (2) an overcoat layer that is coated over the skin-contacting layer; (3) a layer, substantially coplanar with the overcoat layer, that is capable of transporting interstitial fluid by means of chemically aided wicking; (4) a layer, overlying the interstitial fluid transporting layer, that is capable of being placed in contact with a meter, said layer having an opening therein through which light can be transmitted; (5) a layer in communication with the interstitial fluid transporting layer, which layer is capable of detecting the presence of analyte or measuring the amount of analyte in the fluid; (b) placing said element in contact with the skin; (c) providing a source of light; (d) transmitting light through said multiple-layer element such that said light causes an opening to be formed in the skin; (e) collecting interstitial fluid in said fluid transporting layer; (f) transporting interstitial fluid to said analyte detecting layer; (g) detecting the presence of an analyte or measuring the amount of analyte in the fluid.
Claim 2
Dependent Claim
205 words
Method for collecting interstitial fluid and analyzing said fluid for an analyte, said method comprising the steps of: (a) providing a multiple-layer element comprising: (1) a layer that is capable of being placed in contact with the skin of a patient; (2) an overcoat layer that is coated over the skin-contacting layer; (3) a layer, substantially coplanar with the overcoat layer, that is capable of transporting interstitial fluid by means of chemically aided wicking; (4) a layer, overlying the interstitial fluid transporting layer, that is capable of being placed in contact with a meter, said layer having an opening therein through which light can be transmitted; (5) a layer in communication with the interstitial fluid transporting layer, which layer is capable of detecting the presence of analyte or measuring the amount of analyte in the fluid; (b) placing said element in contact with the skin; (c) providing a source of light; (d) transmitting light through said multiple-layer element such that said light causes an opening to be formed in the skin; (e) collecting interstitial fluid in said fluid transporting layer; (f) transporting interstitial fluid to said analyte detecting layer; (g) detecting the presence of an analyte or measuring the amount of analyte in the fluid.
Claim 3
Dependent Claim
16 words
The method of claim 1 , wherein said skin-contacting layer has a target for said light.
Claim 4
Dependent Claim
15 words
The method of claim 2 , wherein said target comprises a dye or a pigment.
Claim 5
Dependent Claim
18 words
The method of claim 1 , wherein said skin-contacting layer bears an adhesive on one major surface thereof.
Claim 6
Dependent Claim
16 words
The method of claim 1 , wherein said interstitial fluid-transporting layer is transparent to said light.
Claim 7
Dependent Claim
14 words
The method of claim 1 , wherein said interstitial fluid-transporting layer is a mesh.
Claim 8
Dependent Claim
15 words
The method of claim 1 , wherein said interstitial fluid transporting layer comprises a surfactant.
Claim 9
Dependent Claim
15 words
The method of claim 1 , wherein said interstitial fluid-transporting layer has an opening therein.
Claim 10
Dependent Claim
18 words
The method of claim 1 , wherein said interstitial fluid-transporting layer and said overcoat layer are substantially coplanar.
Claim 11
Dependent Claim
22 words
The method of claim 1 , wherein said interstitial fluid transporting layer has edges, said edges being embedded in said overcoat layer.
Claim 12
Dependent Claim
18 words
The method of claim 1 , wherein said analyte-detecting layer detects analyte by means of an electrical measurement.
Claim 13
Dependent Claim
18 words
The method of claim 1 , wherein said analyte-detecting layer detects analyte by means of an optical measurement.
Claim 14
Dependent Claim
14 words
The method of claim 1 , wherein said source of light is a laser.
Claim 15
Dependent Claim
18 words
The method of claim 1 , wherein said source of light is a pulsed high intensity white light.
Claim 16
Dependent Claim
18 words
The method of claim 1 , wherein the amount of interstitial fluid collected is less than two microliters.
Claim 17
Dependent Claim
18 words
The method of claim 1 , wherein the amount of interstitial fluid collected is less than one microliter.
Claim 18
Dependent Claim
132 words
Article for collecting and analyzing interstitial fluid to detect the presence of an analyte therein comprising: a multiple-layer element comprising: (1) a layer that is capable of being placed in contact with the skin of a patient; (2) an overcoat layer that is coated over the skin-contacting layer; (3) a layer, substantially coplanar with the overcoat layer, that is capable of transporting interstitial fluid by means of chemically aided wicking; (4) a layer, overlying the interstitial fluid transporting layer, that is capable of being placed in contact with a meter, said layer having an opening therein through which light can be transmitted; (5) a layer in communication with the interstitial fluid transporting layer, which layer is capable of detecting the presence of analyte or measuring the amount of analyte in the fluid.
Claim 19
Dependent Claim
132 words
Article for collecting and analyzing interstitial fluid to detect the presence of an analyte therein comprising: a multiple-layer element comprising: (1) a layer that is capable of being placed in contact with the skin of a patient; (2) an overcoat layer that is coated over the skin-contacting layer; (3) a layer, substantially coplanar with the overcoat layer, that is capable of transporting interstitial fluid by means of chemically aided wicking; (4) a layer, overlying the interstitial fluid transporting layer, that is capable of being placed in contact with a meter, said layer having an opening therein through which light can be transmitted; (5) a layer in communication with the interstitial fluid transporting layer, which layer is capable of detecting the presence of analyte or measuring the amount of analyte in the fluid.
Claim 20
Dependent Claim
15 words
The article of claim 17 , wherein said skin-contacting layer has a target for light.
Claim 21
Dependent Claim
15 words
The article of claim 18 , wherein said target comprises a dye or a pigment.
Claim 22
Dependent Claim
18 words
The article of claim 18 , wherein said skin-contacting layer bears an adhesive on one major surface thereof.
Claim 23
Dependent Claim
15 words
The article of claim 17 , wherein said interstitial fluid-transporting layer is transparent to light.
Claim 24
Dependent Claim
14 words
The article of claim 17 , wherein said interstitial fluid-transporting layer is a mesh.
Claim 25
Dependent Claim
15 words
The article of claim 17 , wherein said interstitial fluid transporting layer comprises a surfactant.
Claim 26
Dependent Claim
15 words
The article of claim 17 , wherein said interstitial fluid-transporting layer has an opening therein.
Claim 27
Dependent Claim
18 words
The article of claim 17 , wherein said interstitial fluid-transporting layer and said overcoat layer are substantially coplanar.
Claim 28
Dependent Claim
21 words
The article of claim 17 , wherein said interstitial fluid-transporting layer has edges, said edges being embedded in said overcoat layer.
Claim 29
Dependent Claim
18 words
The article of claim 19 , wherein said analyte-detecting layer detects analyte by means of an electrical measurement.
Claim 30
Dependent Claim
18 words
The article of claim 17 , wherein said analyte-detecting layer detects analyte by means of an optical measurement.
Claim 31
Dependent Claim
14 words
The article of claim 18 , wherein said light is provided by a laser.
Claim 32
Dependent Claim
18 words
The article of claim 18 , wherein said light is provided by a pulsed high intensity white light.
Claim 33
Dependent Claim
20 words
The article of claim 17 , wherein no more than two microliters of interstitial fluid are required for analyte determination.
Claim 34
Dependent Claim
20 words
The article of claim 17 , wherein no more than one microliter of interstitial fluid is required for analyte determination.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2007-01-19 | 2007-07-21 | 2008-01-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2011-01-19 | 2011-07-21 | 2012-01-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2015-01-19 | 2015-07-21 | 2016-01-20 | $7700.00 | Window Closed / Lapsed |