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US4064164A
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1,3-Di-amino-alkane-1,1-diphosphonic acids and salts
Assignee: Henkel AG and Co KGaA
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Filing: 1976-07-16
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Granted: 1977-12-20
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Expires: 1996-07-16
Abstract
Abstract 1,3-Di-amino-alkane-1,1-diphosphonic acids having the formula ##STR1## wherein R 1 and R 2 are members selected from the group consisting of hydrogen and alkyl having 1 to 3 carbon atoms, and R 3 is a member selected from the group consisting of hydrogen and methyl; as well as their water-soluble salts. The 1,3-diamino-alkane-1,1-diphosphonic acids are excellent sequestering agents especially for alkaline earth metal ions. The compounds are useful in pharmaceutical preparations for treatment of disturbances of calcium or phosphate metabolism or cosmetic preparations such as toothpastes or mouth washes for the prevention of tartar and plaque depositions.
Inventors
- 👤 Helmut Blum
- 👤 Karl-Heinz Worms
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 08:28
CPC Classifications
C; C02; C02F; C02F5/00; C02F5/08; C02F5/10; C02F5/14; A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/55; A61P; A61P3/00; A61P3/12; A61P3/14; A61Q; A61Q11/00; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3839; C07F9/3873; C11; C11D; C11D3/00; C11D3/16; C11D3/36; C11D3/364
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
54 words
A 1,3-di-amino-alkane-1,1-diphosphonic acid compound of the formula ##STR7## wherein R 1 and R 2 are members selected from the group consisting of hydrogen and alkyl having from 1 to 3 carbon atoms and R 3 is a member selected from the group consisting of hydrogen and methyl and a non-toxic, pharmaceutically-acceptable water-soluble salt thereof.
Claim 2
Dependent Claim
54 words
A 1,3-di-amino-alkane-1,1-diphosphonic acid compound of the formula ##STR7## wherein R 1 and R 2 are members selected from the group consisting of hydrogen and alkyl having from 1 to 3 carbon atoms and R 3 is a member selected from the group consisting of hydrogen and methyl and a non-toxic, pharmaceutically-acceptable water-soluble salt thereof.
Claim 3
Dependent Claim
12 words
The 1,3-di-amino-alkane-1,1-diphosphonic acid compound of claim 1 wherein R 3 is hydrogen.
Claim 4
Dependent Claim
12 words
The 1,3-di-amino-alkane-1,1-diphosphonic acid compound of claim 1 wherein R 3 is methyl.
Claim 5
Dependent Claim
20 words
The 1,3-di-amino-alkane-1,1-diphosphonic acid compound of claim 1 wherein R 1 and R 2 are methyl and R 3 is hydrogen.
Claim 6
Dependent Claim
20 words
The 1,3-di-amino-alkane-1,1-diphosphonic acid compound of claim 1 wherein R 1 is methyl and R 2 and R 3 are hydrogen.
Claim 7
Dependent Claim
20 words
The 1,3-di-amino-alkane-1,1-diphosphonic acid compound of claim 1 wherein R 1 and R 2 are hydrogen and R 3 is methyl.
Claim 8
Dependent Claim
18 words
The 1,3-di-amino-alkane-1,1-diphosphonic acid compound of claim 1 wherein R 1 , R 2 and R 3 are hydrogen.
References Cited (Backward Citations)
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Cited
GB995462A
Cited
US3398127A
Cited
US3919296A
Cited
US3925456A
Cited
US3976762A
Cited
US4005160A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-12-19 | 1981-06-20 | 1981-12-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-12-19 | 1985-06-20 | 1985-12-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-12-19 | 1989-06-20 | 1989-12-20 | $7700.00 | Window Closed / Lapsed |