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Patent US4115374A successfully refreshed from Google Patents.
US4115374A
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US
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Substrates for angiotensin converting enzyme
Assignee: Individual
•
Filing: 1977-05-10
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Granted: 1978-09-19
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Expires: 1997-05-10
Abstract
Abstract The novel compounds Iodo-p-hydroxyphenyl-glycylglycylglycine and Benzoylprolylphenylalanylarginine are disclosed, together with radioisotope labeled forms thereof, wherein the radioisotope is incorporated in the Iodo-p-hydroxyphenyl moiety or the Benzoyl moiety, respectively. These compounds are useful as substrates for angiotensin converting enzyme in an assay for that enzyme's activity.
Inventors
- 👤 James Walter Ryan
- 👤 Alfred Chung
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 11:13
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0821; C07K5/0823; C07K5/0802; C07K5/0804; C07K5/0806; C12; C12Q; C12Q1/00; C12Q1/34; C12Q1/37; G; G01; G01N; G01N2333/00; G01N2333/90; G01N2333/914; G01N2333/948; G01N2333/95; G01N2333/964; G01N2333/96425; G01N2333/96427; G01N2333/9643; G01N2333/96486
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
8 words
A composition of matter consisting essentially of ##STR4##
Claim 2
Dependent Claim
8 words
A composition of matter consisting essentially of ##STR4##
Claim 3
Dependent Claim
17 words
The composition of claim 1 wherein at least a portion of the Iodo-p-hydroxyphenylpropionyl moiety contains a radioisotope.
Claim 4
Dependent Claim
21 words
The composition of claim 1 wherein at least a portion of the iodine atoms is replaced by a radioisotope of iodine.
Claim 5
Dependent Claim
8 words
A composition of matter consisting essentially of ##STR5##
Claim 6
Dependent Claim
8 words
A composition of matter consisting essentially of ##STR5##
Claim 7
Dependent Claim
20 words
The composition of claim 4 wherein at least a portion of the benzoyl moiety attached to proline contains a radioisotope.
Claim 8
Dependent Claim
24 words
The composition of claim 4 wherein at least a portion of the hydrogen of the benzoyl moiety attached to proline is replace by tritium.
References Cited (Backward Citations)
US4057629A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-18 | 1982-03-20 | 1982-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-18 | 1986-03-20 | 1986-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-18 | 1990-03-20 | 1990-09-19 | $7700.00 | Window Closed / Lapsed |