Patent US4291012A successfully refreshed from Google Patents.
US4291012A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Technetium-labelled diagnostic agent for the examination of the RES
Assignee: Hoechst AG
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Filing: 1979-01-04
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Granted: 1981-09-22
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Expires: 1999-01-04
Abstract
Abstract A process is disclosed for the preparation of a diagnositc agent for scanning the RES, in particular the liver, by mixing the sodium salt of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone in aqueous solution with tin(II) salt, adjusting the solution to a pH between 4 and 9, optionally lyophilizing the mixture and adding 99m Tc-pertechnetate in physiological saline solution.
Inventors
- 👤 Helmut Strecker
- 👤 Michael Molter
- 👤 Gerhard Kloss
- 👤 Eberhard Schickel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 16:56
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/025; A61K51/04; A61K2123/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
70 words
A process for the preparation of a diagnostic agent for scanning the RES, which comprises mixing the sodium salt of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone in an aqueous solution with tin(II) salt in a molar ratio of 15:1 to 110:1, adjusting the resulting solution to a pH between 4 and 9, and afterwards adding from 0.1 to 100 mCi of 99m Tc-pertechnetate in 1 to 10 ml of physiological saline solution.
Claim 2
Dependent Claim
70 words
A process for the preparation of a diagnostic agent for scanning the RES, which comprises mixing the sodium salt of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone in an aqueous solution with tin(II) salt in a molar ratio of 15:1 to 110:1, adjusting the resulting solution to a pH between 4 and 9, and afterwards adding from 0.1 to 100 mCi of 99m Tc-pertechnetate in 1 to 10 ml of physiological saline solution.
Claim 3
Dependent Claim
26 words
The process as defined in claim 1 wherein the pH adjusted mixture of sodium salt of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid and 1-phenyl-2,3-dimethyl-pyrazolone with tin(II) salt is further lyophilized.
Claim 4
Dependent Claim
25 words
A process as defined in claim 8 wherein the concentration of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylaminomethylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone is in the range of from 0.1 to 200 mg/ml.
Claim 5
Dependent Claim
27 words
A process as claimed in claim 1 or 3 wherein the concentration of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone is in the range of from 1 to 50 mg/ml.
Claim 6
Dependent Claim
51 words
A process as claimed in claim 1 or 3 which comprises reacting a mixture consisting essentially from 1 to 50 mg of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylaminomethylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone and from 0.02 to 1 mg of SnCl 2 .2 H 2 O with 88m Tc-pertechnetate in 1 to 10 ml of physiological saline solution.
Claim 7
Dependent Claim
23 words
A process as claimed in claim 1 or 3 wherein 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone-tin- 99m Tc compounds are in a physiological saline solution.
Claim 8
Dependent Claim
27 words
A diagnostic agent for visualizing the RES consisting essentially of a colloidal 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid-tin(II) 99m Tc compound or colloidal 1-phenyl-2,3-dimethyl-pyrazolone-tin(II) 99m Tc compound in physiologically saline solution.
Claim 9
Dependent Claim
27 words
A diagnostic agent for visualizing the RES consisting essentially of a colloidal 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid-tin(II) 99m Tc compound or colloidal 1-phenyl-2,3-dimethyl-pyrazolone-tin(II) 99m Tc compound in physiologically saline solution.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-21 | 1985-03-23 | 1985-09-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-21 | 1989-03-23 | 1989-09-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-21 | 1993-03-23 | 1993-09-22 | $7700.00 | Window Closed / Lapsed |