Patent US4331646A successfully refreshed from Google Patents.
US4331646A
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Iodine compound for use as a tracer in radioimmunology
Assignee: Commissariat à l'Énergie Atomique et Aux Énergies Alternatives
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Filing: 1979-06-19
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Granted: 1982-05-25
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Expires: 1999-06-19
Abstract
Abstract The compound is constituted by a conjugate compound of an antigen having a free carboxylic function and a dipeptide. The dipeptide is constituted by a product of condensation between tyrosine and a peptide, the tyrosine group of the dipeptide being labeled with radioactive iodine. The compound is highly soluble in water and permits of good recognition by the antibody in antigen-antibody reactions.
Inventors
- 👤 Michel Delaage
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 21:18
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/088; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/58; G01N33/60; G01N33/74; G01N33/88; A61K2123/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
65 words
An iodine labelled compound having the intended function of a tracer for use in radioimmunology as a labeled antigen, wherein said compound is constituted by a conjugate compound obtained by condensing an antigen having a free carboxylic function and a dipeptide, said dipeptide being constituted by a product of condensation between tyrosine and glycine, the tyrosine group of said dipeptide being labeled with radioactive iodine.
Claim 2
Dependent Claim
65 words
An iodine labelled compound having the intended function of a tracer for use in radioimmunology as a labeled antigen, wherein said compound is constituted by a conjugate compound obtained by condensing an antigen having a free carboxylic function and a dipeptide, said dipeptide being constituted by a product of condensation between tyrosine and glycine, the tyrosine group of said dipeptide being labeled with radioactive iodine.
Claim 3
Dependent Claim
15 words
A compound according to claim 1, wherein the antigen is constituted by the juvenile hormone.
Claim 4
Dependent Claim
14 words
A compound according to claim 1, wherein the antigen is constituted by a prostaglandin.
Claim 5
Dependent Claim
15 words
A compound according to claim 1, wherein the antigen is a succinyl derivative of serotonin.
Claim 6
Dependent Claim
12 words
A compound according to claim 1, wherein the antigen is abscissic acid.
Claim 7
Dependent Claim
11 words
A compound according to claim 1, wherein the antigen is progesterone.
Claim 8
Dependent Claim
39 words
A compound according to claim 1, wherein the iodine compound is an analog iodinated derivative of serotonin constituted by a conjugate compound of 5-hydroxy-indole acetic acid and of the glycyl-tyrosine dipeptide, the tyrosine group being labeled with radioactive iodine.
Claim 9
Dependent Claim
34 words
A method of preparing a compound according to claim 1, which method comprises condensing an antigen with a dipeptide condensation product of tyrosine and glycine, and thereafter iodinating, the tyrosine group with radioactive iodine.
Claim 10
Dependent Claim
15 words
A method according to claim 8, wherein the antigen is previously activated by ethyl chloroformate.
Claim 11
Dependent Claim
45 words
A method of preparing a compound according to claim 1, which method comprises first iodinating with radioactive iodine a dipeptide condensation product of tyrosine and glycine to label the tyrosine group thereof with said iodine, and thereafter condensing the thus iodinated dipeptide with an antigen.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-24 | 1985-11-23 | 1986-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-24 | 1989-11-23 | 1990-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-24 | 1993-11-23 | 1994-05-25 | $7700.00 | Window Closed / Lapsed |