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US4469704A
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2,3-Butanediol diester derivatives, process for producing the same, and an antiulcer drug containing the same
Assignee: SS PHARMACEUTICAL Co Ltd 2-12-4 NIHONBASHI HAMA-CHO CHUO-KU TOKYO
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Filing: 1981-12-23
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Granted: 1984-09-04
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Expires: 2001-12-23
Abstract
Abstract The specification describes as antiulcer drug containing as an active ingredient a 2,3-butanediol diester derivative represented by the formula (I): <IMAGE> (I) where RA may for example be a saturated or unsaturated alkyl or phenyl styryl group and RB may for example be a saturated or unsaturated alkyl, phenyl, phenylalkyl, phenylpropenyl or phenoxyalkyl group. These groups may optionally be substituted. Many of 2,3-butanediol diester derivatives embraced by the formula (I) are novel. Also described are a novel process for preparing such novel 2,3-butanediol diester derivatives. The 2,3-butandiol diester derivatives of the formula (I) has an action to depress strongly the growth of peptic ulcer and has a very low toxicity.
Inventors
- 👤 Susumu Satoh
- 👤 Kinichi Mogi
- 👤 Saburo Murakami
- 👤 Toshiaki Nakashima
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 15:59
CPC Classifications
C; C07; C07C; C07C255/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
177 words
An antiulcer composition comprising, as an active ingredient, an antiulcer effective amount of a 2,3-butanediol diester represented by the formula (I): ##STR59## where R A is a saturated alkyl group which may have a branched chain, or a group represented by the formula ##STR60## where R 1 is hydrogen, cyano or lower alkyl, and R 2 is hydrogen, halogen, lower alkyl, lower alkyloxy or lower acyloxy; R B is a saturated alkyl group which may have a branched chain, phenyl group which may be substituted with lower alkyl, lower alkoxy or halogen, phenyl alkyl, phenyl propenyl, phenyloxy alkyl or a group represented by the formula ##STR61## where R 3 is hydrogen, halogen, cyano, lower alkyl or phenyl, R 4 is hydrogen, lower alkyl or phenyl, and R 5 is phenyl which may be substituted with lower alkyl, lower alkoxy, acyloxy or halogen; and a pharmaceutically acceptable compound selected from the group consisting of a diluent, a binder, a disintegrator, a lubricant, a fluidity improving agent, olive oil, peanut oil, water, physiological saline, cacao butter and synthetic fat.
Claim 2
Dependent Claim
177 words
An antiulcer composition comprising, as an active ingredient, an antiulcer effective amount of a 2,3-butanediol diester represented by the formula (I): ##STR59## where R A is a saturated alkyl group which may have a branched chain, or a group represented by the formula ##STR60## where R 1 is hydrogen, cyano or lower alkyl, and R 2 is hydrogen, halogen, lower alkyl, lower alkyloxy or lower acyloxy; R B is a saturated alkyl group which may have a branched chain, phenyl group which may be substituted with lower alkyl, lower alkoxy or halogen, phenyl alkyl, phenyl propenyl, phenyloxy alkyl or a group represented by the formula ##STR61## where R 3 is hydrogen, halogen, cyano, lower alkyl or phenyl, R 4 is hydrogen, lower alkyl or phenyl, and R 5 is phenyl which may be substituted with lower alkyl, lower alkoxy, acyloxy or halogen; and a pharmaceutically acceptable compound selected from the group consisting of a diluent, a binder, a disintegrator, a lubricant, a fluidity improving agent, olive oil, peanut oil, water, physiological saline, cacao butter and synthetic fat.
Claim 3
Dependent Claim
15 words
The antiulcer composition according to claim 1, wherein the diluent is starch, lactose or mannitol.
Claim 4
Dependent Claim
15 words
The antiulcer composition according to claim 1, wherein the binder is sodium carboxymethylcellulose or hydroxypropylcellulose.
Claim 5
Dependent Claim
15 words
The antiulcer composition according to claim 1, wherein the disintegrator is crystalline cellulose calcium carboxymethylcellulose.
Claim 6
Dependent Claim
15 words
The antiulcer composition according to claim 1, wherein the lubricant is talc or magnesium stearate.
Claim 7
Dependent Claim
16 words
The antiulcer composition according to claim 1, wherein the fluidity improving agent is light silicic anhydride.
Claim 8
Dependent Claim
18 words
The antiulcer composition according to claim 1, in the form of powder, tablets, capsules, granules, solutions or suppositories.
Claim 9
Dependent Claim
13 words
The antiulcer composition according to claim 1 in a form for oral administration.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-04 | 1988-03-05 | 1988-09-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-04 | 1992-03-05 | 1992-09-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-04 | 1996-03-05 | 1996-09-04 | $7700.00 | Window Closed / Lapsed |